Category: 70057-67-9

Song, Xin-Jian; Wang, Xu-Mei; Qi, Sun; Huang, Sheng-Tian; Yan, Wang published the artcile< Synthesis, crystal structure and antitumor activity of N-(5-aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas>, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aryl thiadiazolyl styryl urea preparation antitumor activity.

A series of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas I (R = 2-F, 3-Me, 4-Cl, etc.) was designed and synthesized as antitumor agents. The single crystal of compound I (R = 2-F) was also determined by X-ray crystallog. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) Å, β = 93.320(3)°, V = 1572.4(5) Å3, Z = 4, F(000) = 704, Dc = 1.438 g/cm3, μ = 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections (Rint = 0.0418) and 2174 observed ones (I > 2σ(I)) were provided. The in vitro antitumor activities of compounds I were preliminarily evaluated by the standard MTT assay.

Chinese Journal of Structural Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zender, Michael; Klein, Tobias; Henn, Claudia; Kirsch, Benjamin; Maurer, Christine K.; Kail, Dagmar; Ritter, Christiane; Dolezal, Olan; Steinbach, Anke; Hartmann, Rolf W. published the artcile< Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence>, COA of Formula: C8H6ClN3S, the main research area is aminooxadiazole antibacterial protein PqsR Pseudomonas.

The human pathogen Pseudomonas aeruginosa employs alkyl quinolones for cell-to-cell communication. The Pseudomonas quinolone signal (PQS) regulates various virulence factors via interaction with the transcriptional regulator PqsR. Therefore, the authors considered the development of PqsR antagonists as a novel strategy to limit the pathogenicity of P. aeruginosa. A fragment identification approach using surface plasmon resonance screening led to the discovery of chem. diverse PqsR ligands. The optimization of the most promising hit (5) resulted in the oxadiazole-2-amine 37 showing pure antagonistic activity in Escherichia coli (EC50 = 7.5 μM) and P. aeruginosa (EC50 = 38.5 μM) reporter gene assays. Compound 37 was able to diminish the production of the PQS precursor HHQ in a PqsH-deficient P. aeruginosa mutant. The level of the major virulence factor pyocyanin was significantly reduced in wild-type P. aeruginosa. In addition, site-directed mutagenesis in combination with isothermal titration calorimetry and NMR INPHARMA experiments revealed that the identified ligands bind to the same site of PqsR by adopting different binding modes. These findings might be utilized in a future fragment-growing approach aiming at novel therapeutic options for the treatment of P. aeruginosa infections.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, COA of Formula: C8H6ClN3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Makwane, Sunil; Srivastava, S. D.; Dua, Rajiv; Srivastava, S. K. published the artcile< Synthesis of 10-(2-phenyl-imidazo [2, 1-b] [1,3,4]thiadiazol-6-yl)-10H-phenothiazine derivatives and their in-vitro biological studies>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is phenyl dihydroimidazothiadiazolyl phenothiazine preparation antifungal antibacterial activity SAR.

New series of 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazine were synthesized by cyclization of various carboxylic acid with thiosemicarbazide in presence of sulfuric acid was to get aminothiadiazoles. Another way phenothiazine treated with chloroacetyl chloride yielded chloroacetyl phenothiazine . Further, cyclization of aminothiadiazoles and chloroacetyl phenothiazine followed by refluxation about 18 h to get the final products 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazines. The structures of compounds were confirmed by IR, 1H-NMR, 13C NMR and mass spectroscopy and by chem. anal. All the above compounds were screened for their antimicrobial activity against some selected bacteria and fungi such as E. coli, B. subtilis, and S. typhi bacteria and A.niger, A. flavus and F. oxisporium fungi.

Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics