Category: 7051-15-2

Synthetic Route of 7051-15-2, A common heterocyclic compound, 7051-15-2, name is 2-Chloro-1,3-dimethoxybenzene, molecular formula is C8H9ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 3-Chloro-2,4-dimethoxybenzaldehyde (2a) was prepared from 1,3-dimethoxybenzene (1a) according to Plattner, J. J. et al. J. Med. Chem. 1984, 27 (8), 1016-1026. 3-(3-Chloro-2,4-dimethoxyphenyl)acrylic acid (3a).

The synthetic route of 7051-15-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Epoch Biosciences, Inc.; US2005/171340; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 7051-15-2, name is 2-Chloro-1,3-dimethoxybenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7051-15-2, Quality Control of 2-Chloro-1,3-dimethoxybenzene

General procedure: A typical procedure is given for the reaction represented by Entry 8 in Table 1. Ligand 2e (6 mg, 0.01 mmol), Pd2(dba)3 (5 mg, 0.005 mmol), 2-methylnaphthyl-1-boronic acid (223 mg, 1.2 mmol), Cs2CO3 (975 mg, 3 mmol) were introduced to a flask under N2 gas. 1-bromo-2-methylnaphthalene (221 mg, 1 mmol) was added into the flask, followed by addition of THF (5 ml) by a syringe. The mixture was stirred under reflux for 24 h, under ambient pressure of N2. The solvent was then removed under reduced pressure. The resultant residual mixture was diluted with H2O (10 ml) and Et2O (10 ml), followed by extraction twice with Et2O. The organic extract was collected and stripped of solvent under vacuum. The product was isolated by column chromatography on silica eluting with hexane/ethyl acetate to give 276 mg (98%) of 2,2′-dimethyl-1-1′-binaphthalene as a solid, which was verified by GC/MS.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-1,3-dimethoxybenzene, and friends who are interested can also refer to it.

Reference:
Conference Paper; Teo, Shihui; Weng, Zhiqiang; Hor, T.S. Andy; Journal of Organometallic Chemistry; vol. 696; 17; (2011); p. 2928 – 2934;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 7051-15-2, name is 2-Chloro-1,3-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-1,3-dimethoxybenzene

The 13.9g acetophenone (115.6mmol), 10.9g chlorobenzene (96.7mmol), 11.1g sodium tert-butoxide (115.6mmol) and 0.35g azacarbene imine palladium catalyst added in Example 6 9.8g p-cyanoacetophenone (67.3mmol), 9.6g 2,6-dimethoxychlorobenzene (56.1mmol), 6.5g sodium tert-butoxide (60mmol) and 0.2g azacyclocarbene imines The palladium catalyst and 60 mL of 1,4-dioxane solvent were not changed under other conditions, and the target product was obtained 14.0 g, and the isolated yield was 89%.In Example 6, the 0.35g nitrogen heterocyclic carbene imine palladium catalyst A1 was replaced with 0.24g A2, 0.29g A3, 0.34g A4, 0.24g A5, and the separation yields were 98%, 96%, 90%, 90%.

The synthetic route of 2-Chloro-1,3-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Chemical Institute Co., Ltd.; Lu Huiyang; Shen An; Cao Yucai; Li Yongqing; Ni Chen; Hu Yucai; (14 pag.)CN110818545; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics