Category: 7079-48-3

Kas’yan, A. O. published the artcileNew N-(arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes. Synthesis, 1H and 13C NMR spectra, and chemical reactions, Formula: C7H6ClFO2S, the main research area is arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation.

N-(Arylsulfonyl)-5-aminomethylbicyclo[2.2.1]hept-2-enes (I) were obtained by reaction of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes with arylsulfonyl chlorides. The contribution of the stereochem. features of the sulfonamides to the spectral structure of the endo- and exo-isomers of I was evaluated with the use of 1H and 13C NMR spectral data, including those of two-dimensional COSY and NOESY spectra. Phase-transfer catalysis alkylation and acylation of I was carried out. The reactions of endo- and exo-5-[N-benzyl-N-(3,4-dichlorophenylsulfonyl)aminomethyl]bicyclo[2.2.1]hept-2-enes with peroxyphthalic acid yielded epoxides; the orientation of substituents in the cage norbornene fragment does not affect the direction of this process.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about arylsulfonylaminomethylbicycloheptne preparation alkylation acylation epoxidation. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Formula: C7H6ClFO2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nycholat, Corwin M. published the artcileA sulfonamide sialoside analogue for targeting Siglec-8 and -F on immune cells, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is sulfonamide sialoside analog Siglec8 ligand immune cell targeting.

The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor signaling. Human Siglec-8, for instance, has been identified as a therapeutic target for the treatment of eosinophil and mast cell disorders. A promising strategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Siglec ligands. A key challenge for this approach is the identification of a high affinity ligand for the target Siglec. Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogs was screened to identify potential lead compounds The best ligand, 9-N-(2-naphthyl-sulfonyl)-Neu5Acα2-3-[6-O-sulfo]-Galβ1-4GlcNAc (6′-O-sulfo NSANeu5Ac) combined the lead 2-naphthyl sulfonyl C-9 substituent with the preferred sulfated scaffold. The ligand 6′-O-sulfo NSANeu5Ac was conjugated to lipids for display on liposomes to evaluate targeted delivery to cells. Targeted liposomes showed strong in vitro binding/uptake and selectivity to cells expressing Siglec-8 or -F and, when administered to mice, exhibit in vivo targeting to Siglec-F+ eosinophils.

Journal of the American Chemical Society published new progress about B cell. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis of fused sulfonamide (1,1-dioxoisothiazole)-substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is pyrazole benzoisothiazolyl aryl preparation cyclooxygenase inhibitor.

First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted arylpyrazoles, e.g., I, has been accomplished via oxidative cyclization of 4-fluoro-2-Me benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biol. interest. In studies evaluating cyclooxygenase inhibiting activity, I was found to be more than 100 fold selective in COX-2 inhibition over COX-1.

Journal of the Indian Chemical Society published new progress about Homo sapiens. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kas’yan, A. O. published the artcileDerivatives of exo-5-Aminomethyl-endo-5-methylbicyclo-[2.2.1]hept-2-ene and exo-5-Aminomethyl-endo-5-methyl-exo-2,3-epoxybicyclo[2.2.1]heptane, Formula: C7H6ClFO2S, the main research area is methylbicycloheptenemethanamine aminomethylbicycloheptene preparation; aminomethylepoxybicycloheptane oxatricyclooctanemethanamine preparation; rotational conformational barrier methylbicycloheptenemethanamine oxatricyclooctanemethanamine preparation.

(1R,2S,4R)-rel-2-methylbicyclo[2.2.1]hept-5-ene-2-methanamine (exo-isomer, I) and (1R,2R,4S,5S,6S)-rel-6-methyl-3-oxatricyclo[3.2.1.02,4]octane-6-methanamine were synthesized, and their geometric parameters and conformational properties, in particular the barriers to rotation of the aminomethyl fragment about the exocyclic C5-C bond, were studied by the mol.-mechanics method (MMX) and compared with those found for structurally related to I. The title compounds were brought into reactions with electrophilic reagents: arenesulfonyl chlorides, isocyanates, and isothiocyanates. The neurotropic activity of two compounds thus prepared was mentioned.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about Conformation. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Formula: C7H6ClFO2S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bajare, Swapnil published the artcileSynthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist, Category: chlorides-buliding-blocks, the main research area is PPARgamma agonist quinolinyloxypyridinylbenzenesulfonamide preparation; benzenesulfonamide quinolinyloxypyridinyl preparation PPARgamma agonist.

The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor. Ligands for PPARγ regulate adipocyte production and secretion of fatty acids as well as glucose metabolism, resulting in increased insulin sensitivity in adipose tissue, liver, and skeletal muscle. However, TZDs have several adverse effects, including weight gain and liver toxicity. Herein we report identification of non-TZD PPARγ agonists [I, Ar = substituted Ph] which exhibit beneficial effects similar to that of TZDs in animal models, but without the associated adverse effects.

European Journal of Medicinal Chemistry published new progress about Adipogenesis. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deka, Nabajyoti published the artcileSynthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives for the treatment of metabolic syndrome, Recommanded Product: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is piperazinyl pyridinyl benzenesulfonamide preparation metabolic syndrome.

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligands and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. The synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives I (R = 2,4-Cl2C6H3, 2,5-(OCH3)2C6H3, 2-thienyl, etc.) an alternate remedy for insulin resistance is reported.

International Journal of Medicinal Chemistry published new progress about Adipogenesis. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Recommanded Product: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, M. published the artcileSynthesis and structure-activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is diazaspirodecanedione amino fluorophenoxyethyl preparation anticonvulsant.

A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives was synthesized and their pharmacol. activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds I [R = 4-MeC6H4NHCO, 3-MeC6H4NHCO, 2-CF3C6H4NHCO] showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having an amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.

Medicinal Chemistry Research published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, Malavalli published the artcileSynthesis and Pharmacological Evaluation of Novel 1′-[2-(Difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-diones and Their Derivatives, Related Products of chlorides-buliding-blocks, the main research area is difluoromethoxyphenylmethyl spiro azabicyclooctane imidazolidine preparation anticonvulsant; Anticonvulsant; Isocyanate; Maximal electroshock; ScPTZ; Spirohydantoins.

A series of novel 1′-[2-(difluoromethoxy)benzyl]-2’H,5’H-spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione substituted hydantoins was synthesized using an appropriate synthetic route and characterized by elemental anal. and spectral data. The novel mols. were screened for anticonvulsant activity in mice by maximal electroshock (MES) and s.c. pentylenetetrazol (ScPTZ)-induced seizure tests. The neurotoxicity was assessed using the rotarod method. Several compounds exhibited anticonvulsant activity in an MES seizure model and in a ScPTZ model, with lower neurotoxicity. Some title compounds showed lower central nervous system depression compared to phenytoin. The synthesis of the target compounds was achieved by a reaction of [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione with arenesulfonyl chlorides or aryl isocyanates. The title compounds thus formed included [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione sulfonamide analogs , such as a 4-fluoro-2-methylbenzenesulfonamide analog (I) and [[(difluoromethoxy)phenyl]methyl]spiro[8-azabicyclo[3.2.1]octane-3,4′-imidazolidine]-2′,5′-dione amide analogs.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Anticonvulsants. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Di Matteo, Mauro published the artcileSynthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors, Category: chlorides-buliding-blocks, the main research area is imidazolylmethylpiperidine sulfonamide preparation aromatase inhibitor; Anticancer agents; Aromatase inhibitor; Imidazole; Sulfonamide; Synthesis.

The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC50 values that are similar to that of letrozole and SYN 20028567 were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reed, Nilgun Isik published the artcileExploring N-Arylsulfonyl-L-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is arylsulfonylproline scaffold preparation alphavbeta1 integrin inhibitor structure activity antifibrotic; RGF mimetic preparation alphavbeta1 integrin inhibitor structure activity antifibrotic; Fibrosis; TGFβ; integrin antagonist; phenylsulfonylproline; αvβ1 integrin.

One small mol. inhibitor of αvβ1 integrin, RGD mimetic c8, shows antifibrotic effects in multiple in vivo mouse models. Here the authors synthesized c8 analogs and systematically investigate their structure-activity relationships (SAR) in αvβ1 integrin inhibition. N-Phenylsulfonyl-L-homoproline analogs of c8 maintained excellent potency against αvβ1 integrin while retaining good selectivity over other RGD integrins. In addition, 2-aminopyridine or cyclic guanidine analogs were shown to be equally potent to c8. A rigid Ph linker increased the potency compared to c8, but the selectivity over other RGD integrins diminished. These results can provide further insights on design of αvβ1 integrin inhibitors as antifibrotics.

ACS Medicinal Chemistry Letters published new progress about Antifibrotic agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics