Category: 7080-50-4

Rotroff, Daniel M. published the artcilePredictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Environmental Science & Technology (2014), 48(15), 8706-8716, database is CAplus and MEDLINE.

Thousands of environmental chems. are subject to regulatory review for their potential to be endocrine disruptors (ED). In vitro high-throughput screening (HTS) assays have emerged as a potential tool for prioritizing chems. for ED-related whole-animal tests. In this study, 1814 chems. including pesticide active and inert ingredients, industrial chems., food additives, and pharmaceuticals were evaluated in a panel of 13 in vitro HTS assays. The panel of in vitro assays interrogated multiple end points related to estrogen receptor (ER) signaling, namely binding, agonist, antagonist, and cell growth responses. The results from the in vitro assays were used to create an ER Interaction Score. For 36 reference chems., an ER Interaction Score >0 showed 100% sensitivity and 87.5% specificity for classifying potential ER activity. The magnitude of the ER Interaction Score was significantly related to the potency classification of the reference chems. ERα/ERβ selectivity was also evaluated, but relatively few chems. showed significant selectivity for a specific isoform. When applied to a broader set of chems. with in vivo uterotrophic data, the ER Interaction Scores showed 91% sensitivity and 65% specificity. Overall, this study provides a novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chem. prioritization.

Environmental Science & Technology published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roszkowski, Piotr published the artcileNovel (+)-3-carene derivatives and their application in asymmetric synthesis, COA of Formula: C7H13ClNNaO5S, the publication is Synthesis (2015), 47(4), 569-574, database is CAplus.

A simple synthetic procedure for the preparation of mono-N-tosylated 1,2-diamines derived from (+)-3-carene is described. (+)-3-Carene is transformed into the corresponding N-tosylaziridine using chloramine-T trihydrate. Subsequent ring-opening with NaN₃, followed by reduction of the azide function gives the optically pure mono-N-tosylated 1,2-diamine. This ligand is effective in asym. transfer hydrogenations of aromatic ketones. It can also be transformed into other chiral ligands by alkylation of the amino group for application in the addition of Et₂Zn to benzaldehydes.

Synthesis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sureshkumar, Devarajulu published the artcileRegio- and Stereoselective Synthesis of Aziridino Epoxides from Cyclic Dienes, Synthetic Route of 7080-50-4, the publication is Journal of Organic Chemistry (2006), 71(4), 1653-1657, database is CAplus and MEDLINE.

Two different routes for the regio- and stereoselective synthesis of aziridino epoxides from cyclic dienes have been explored. The first strategy involves regiospecific aziridination of cyclic diene derivatives and subsequent epoxidation with m-CPBA to yield cis-aziridino epoxides as major products. The second strategy utilizes regiospecific epoxidation of cyclic diene derivatives followed by Sharpless aziridination to provide exclusively trans-aziridino epoxides. Synthesis of both enantiomers of cis-aziridino epoxides from (R)-(-)- and (S)-(+)-carvones are also reported.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H6ClNO, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosal, Nirnita Chakraborty published the artcileA Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines, Formula: C7H13ClNNaO5S, the publication is SynOpen (2017), 1(1), 0015-0023, database is CAplus.

A new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH₂OH·HCl and NaIO₄. The same combination of NH₂OH·HCl and NaIO₄ was also very effective for nucleophilic ring opening of aziridines.

SynOpen published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herbort, James H. published the artcileCationic Co(I) Catalysts for Regiodivergent Hydroalkenylation of 1,6-Enynes: An Uncommon cis-α-C-H Activation Leads to Z-Selective Coupling of Acrylates, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is ACS Catalysis (2021), 11(15), 9605-9617, database is CAplus and MEDLINE.

Two intermol. hydroalkenylation reactions of 1,6-enynes N(R)(CH²CH=CH²)CH²CCR¹ (R = -N(Ts)-, -C(COOEt)₂-, -O-, -N(Boc)-; R¹ = 4-fluorophenyl, thiophen-3-yl, prop-1-en-2-yl, etc.) are presented which yield substituted 5-membered carbo- and -heterocycles I (R = -N(Ts)-, -C(COOEt)²-; R² = H, Me; R³ = H, Me, n-Bu). This reactivity is enabled by a cationic bis-diphenylphosphinopropane (DPPP)CoI species which forms a cobaltacyclopentene intermediate by oxidative cyclization of the enyne. This key species interacts with alkenes in distinct fashion, depending on the identity of the coupling partner to give regiodivergent products I. Simple alkenes undergo insertion reactions to furnish 1,3-dienes whereby one of the alkenes is tetrasubstituted. The acerylates R⁴CH=C(R⁵)C(O)OR⁶ (R⁴ = H, Me, OMe; R⁵ = H, Me; R⁶ = Me, Bn, Cy, t-Bu) were employed as coupling partners, and the site of intermol. C-C formation shifts from the alkyne to the alkene motif of the enyne, yielding Z-substituted-acrylate derivatives II. Computational studies provide support for the exptl. observations and show that the turnover-limiting steps in both reactions are the interactions of the alkenes with the cobaltacyclopentene intermediate via either a 1,2-insertion in the case of ethylene, or an unexpected α-C-H activation in the case of most acrylates. Thus, the H syn to the ester is activated through the coordination of the acrylate carbonyl to the cobaltacycle intermediate, which explains the uncommon Z-selectivity and regiodivergence. Variable time normalization anal. (VTNA) of the kinetic data reveals a dependence upon the concentration of cobalt, acrylate, and activator. A KIE of 2.1 was observed with Me methacrylate in sep. flask experiments, indicating that C-H cleavage is the turnover-limiting step in the catalytic cycle. Lastly, a Hammett study of aryl-substituted enynes yields a ρ value of -0.4, indicating that more electron-rich substituents accelerate the rate of the reaction.

ACS Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Safety of Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gioti, Efthymia G. published the artcileA new scalable synthesis of entecavir, Application In Synthesis of 7080-50-4, the publication is Tetrahedron (2018), 74(4), 519-527, database is CAplus.

A new synthesis of entecavir from D-glucose in an average total yield of 3.5% was achieved via an intramol. nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Esmaeilzadeh, Pegah published the artcileStimuli-responsive multilayers based on thiolated polysaccharides that affect fibroblast cell adhesion, HPLC of Formula: 7080-50-4, the publication is ACS Applied Materials & Interfaces (2018), 10(10), 8507-8518, database is CAplus and MEDLINE.

Control of the biomaterial properties through stimuli-responsive polymeric platforms has become an essential technique in recent biomedical applications. A multilayer system of thiolated chitosan (t-Chi) and thiolated chondroitin sulfate (t-CS), consisting of five double layers ([t-Chi/t-CS]₅), was fabricated here by applying a layer-by-layer coating strategy. To represent a novel class of chem. tunable nanostructures, the ability to cross-link pendant thiol groups was tested by a rise from pH 4 during layer formation to pH 9.3 and a more powerful chem. stimulus by using chloramine-T (ChT). Following both treatments, the resulting multilayers showed stimuli-dependent behavior, as demonstrated by their content of free thiols, wettability, surface charge, elastic modulus, roughness, topog., thickness, and binding of fibronectin. Studies with human dermal fibroblasts further demonstrated the favorable potential of the ChT-responsive multilayers as a cell-adhesive surface compared to pH-induced crosslinking. Because the [t-Chi/t-CS]₅ multilayer system is responsive to stimuli such as the pH and redox environment, multilayer systems with disulfide bond formation may help to tailor their interaction with cells, film degradation, and controlled release of bioactive substances like growth factors in a stimuli-responsive manner useful in future wound healing and tissue engineering applications.

ACS Applied Materials & Interfaces published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Goldberg, Frederick W. published the artcileGeneral synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor, SDS of cas: 7080-50-4, the publication is Tetrahedron (2014), 70(37), 6613-6622, database is CAplus.

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clin. candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesizing a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, com. available precursor is discussed.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, SDS of cas: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abhishek, Verma published the artcileMechanistic aspect of Iridium(III) catalyzed oxidation of ethylene glycol by Chloramine-T in aqueous acidic medium: a kinetic model, Formula: C7H13ClNNaO5S, the publication is G P Globalize Research Journal of Chemistry (2018), 1(2), 107-115, database is CAplus.

The kinetic investigation of homogeneously Ir(III) chloride catalyzed oxidation of Ethylene glycol by Chloramine- T [CAT] in perchloric acid medium has been carried out in the temperature range of 30 to 45°C. The reaction was carried out in the presence of mercuric acetate as a scavenger for chloride ion. The reaction exhibits first order kinetics with respect to the oxidant [CAT] and catalyst [Ir(III)] while zero order with respect to substrate, i.e., Ethylene glycol (EG) was observed The reaction shows negligible effect of [Hg(OAc)₂], [H⁺] and ionic strength of the medium. Chloride ion pos. influenced the rate of reaction. The various activation parameters have been calculated from the rate measurements at different temperatures (30 to 45°C). The product of the reaction has been identified as the corresponding monocarboxylic acid. The reaction between Chloramine-T and Ethylene glycol in acid medium shows 2:1 stoichiometry. On the basis of kinetic studies, reaction stoichiometry and product anal., a suitable mechanism has been proposed and rate law has been derived.

G P Globalize Research Journal of Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Darses, Benjamin published the artcileAsymmetric synthesis of amines through rhodium-catalyzed C-H amination with sulfonimidoylnitrenes, Quality Control of 7080-50-4, the publication is Synthesis (2013), 45(15), 2079-2087, database is CAplus.

An efficient asym. C-H amination of benzylic and allylic substrates, as well as of adamantane derivatives, through catalytic C-H insertion of a chiral nitrene is reported. The reaction involves a chiral rhodium(II) complex, an iodine(III) oxidant, and a sulfonimidamide as a nitrene precursor. Exptl. protocols for the preparation of the reagents and the catalytic nitrene are provided. The C-H amination can provide the corresponding amino derivatives on a gram scale. Various methods for the cleavage of the sulfonimidoyl group to give the corresponding tert-butoxycarbonyl- or acetyl-protected optically pure amines are also described.

Synthesis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics