Category: 7080-50-4

Zheng, Yuxin published the artcileRegiodivergent Desymmetrization Reaction of meso-Azabicycloheptene Providing Two Enantioenriched Structural Isomers, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Letters, database is CAplus and MEDLINE.

A novel catalytic asym. reaction uses the regiodivergent desymmetrization of 7-tosyl-7-azabicyclo[4.1.0]hept-3-ene via allylic oxidation using a single chiral copper catalyst to produce two different, enantioenriched structural isomers in high optical purity starting from a single compound The enantioselectivity of the two structurally isomeric compounds was enriched to >99.5%ee after derivatization.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C26H26N4O7, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ng, Wing-Hin published the artcileZwitterion-Catalyzed Intermolecular Bromoesterifications, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Letters (2020), 22(14), 5572-5576, database is CAplus and MEDLINE.

Intermol. haloesterification is an important class of transformations. The resulting products are valuable building blocks. However, it is often necessary to use super-stoichiometric amount of acid in order to compensate the low reactivity. Herein, we report a zwitterion-catalyzed intermol. bromoesterification using acid and olefin in an equimolar ratio. Mechanistic study revealed that the charge pair in the zwitterion works synergistically in activating both NBS and carboxylic acid.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lois, Isabella published the artcileThe effect of the r_cation/r_anion ratio on the structural and chemical properties of N-chloroarenesulfonamidates, Computed Properties of 7080-50-4, the publication is Inorganica Chimica Acta (2007), 360(8), 2686-2696, database is CAplus.

A comparative structural study on sodium and potassium N-chloroarenesulfonamidates was carried out using x-ray diffraction and IR spectroscopy as exptl. techniques. As shown by crystallog. studies, the sodium ions tend to incorporate more water oxygen atoms in their coordination spheres than the potassium ions, while the potassium congeners prefer the interaction with sulfonamidate moieties. The marked dissimilarity between the compositions of the coordination spheres as well as the different tendency of the sodium and potassium salts to absorb moisture from the air were attributed to the different sizes of the sodium and potassium ions. The opposite shifts of the ν _as(SO₂) and ν(SN) bands upon dehydration were ascribed to an increased polarization of the sulfonyl group by the metal centers. Based on IR spectroscopic observations, a weakening of the N-Cl bonds is suspected in the water-free compounds, which may contribute to the known thermal instability of the dehydrated salts of N-chloroarenesulfonamides. Various sections of IR spectra as well as x-ray powder diffraction patterns proved to be suitable to identify the water-free and hydrated samples.

Inorganica Chimica Acta published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Computed Properties of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sureshkumar, Devarajulu published the artcileTandem aziridine ring opening-disulfide formation-reduction-Michael addition in one-pot mediated by tetrathiomolybdate, SDS of cas: 7080-50-4, the publication is Tetrahedron (2015), 71(39), 7267-7281, database is CAplus.

A detailed study of tetrathiomolybdate mediated tandem regio- and stereoselective ring opening of aziridine, disulfide formation, reduction of disulfide bond and Michael reaction in a one-pot operation is reported. This constitutes four reactions that take place in one-pot operation. In the reaction of [BnEt₃N]₄MoS₄ with an aziridine derived from cyclohexene and in the absence of Michael acceptor intermediates sulfonamidodisulfide and sulfonamidothiol were isolated and fully characterized. It has also been shown that it is possible to carry out selective opening of the aziridine ring in the presence of an epoxide. By incorporating a suitable Michael acceptor as part of the substrate, intramol. 1,4-addition could be performed, to achieve the synthesis of sulfur containing acyclic, cyclic amino acid ester derivatives and thia-bicyclo[3.3.1]nonane derivatives in good yields.

Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C4H11NO, SDS of cas: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Craig, Donald published the artcileTransannular, decarboxylative Claisen rearrangement reactions for the synthesis of sulfur-substituted vinylcyclopropanes, Application In Synthesis of 7080-50-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(27), 4991-4993, database is CAplus and MEDLINE.

Unsaturated ε-lactones, e.g., I, bearing an α-arylsulfonyl or α-arylsulfoximinyl substituent undergo stereoselective transannular, decarboxylative Claisen rearrangement to give substituted vinylcyclopropanes, e.g., II.

Chemical Communications (Cambridge, United Kingdom) published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wei, Zhengxi published the artcileA direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers, Quality Control of 7080-50-4, the publication is Toxicology Letters (2021), 67-77, database is CAplus and MEDLINE.

Chem.-peptide conjugation is the mol. initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatog./UV (HPLC/UV) detection method to quantify chem.-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput, sensitivity and accuracy, an automated 384-well plate-based RapidFire solid-phase extraction (SPE) system coupled with tandem mass spectrometry (MS/MS) DPRA was developed and validated in the presence of a newly designed internal standard Compared to the HPLC/UV-based DPRA, the automated SPE-MS/MS-based DPRA improved throughput from 16 min to 10 s per sample, and substrate peptides usage was reduced from 100 mM to 5μM. When implementing the SPE-MS/MS-based DPRA into a high-throughput platform, we found 10 compounds that depleted lysine peptide and 24 compounds that depleted cysteine peptide (including 7 unreported chems. from 55 compounds we tested) in a concentration-response manner. The adduct formation between cysteine and cinnamic aldehyde and ethylene glycol dimethacrylate were further analyzed using high-performance liquid chromatog. time-of-flight mass spectrometry (HPLC-TOF-MS) to confirm the conjugation. Overall, the automated SPE-MS/MS-based platform is an efficient, economic, and accurate way to detect skin sensitizers.

Toxicology Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C6H6N2O, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xing, Siyang published the artcileDiastereoselective synthesis of cis-1,3-disubstituted isoindolines via a highly site-selective tandem cyclization reaction, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is Organic Chemistry Frontiers (2018), 5(12), 1950-1956, database is CAplus.

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes was described. O-atom nucleophiles, produced by the reaction of aldehydes and NHCs in open air, preferred to attack the less hindered aziridine carbons, followed by further intramol. aza-Michael addition to afford a series of cis-1,3-disubstituted isoindolines in good yields with good diastereoselectivities. High selectivities, high efficiency and mild conditions made this tandem reaction very suitable for the rapid construction of libraries of isoindoline compounds

Organic Chemistry Frontiers published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H17N3O2, Safety of Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rubin, Heather published the artcileScalable Synthesis of N-Acylaziridines from N-Tosylaziridines, Name: Sodium chloro(tosyl)amide trihydrate, the publication is Journal of Organic Chemistry (2013), 78(17), 8865-8871, database is CAplus and MEDLINE.

N-Acylaziridines are important starting materials for the synthesis of chiral amine derivatives The traditional methods for producing these activated aziridines have significant drawbacks. The gram scale synthesis of N-acylaziridines by deprotection of N-tosylaziridines and reprotection with N-hydroxysuccinimide derivatives is described. Mono- and disubstituted aziridines perform well, with complete retention of stereochem. purity. The consistently moderate yields are linked to the N-tosylaziridine deprotection step, while acylation with N-hydroxysuccinimide derivatives is highly efficient.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Name: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics