Category: 72235-56-4

Synthetic Route of 72235-56-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72235-56-4 name is 3-Chloro-4-fluorobenzylamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 8-(benzyloxy)-2-methyl-1-oxo-1, 2,3, 4-tetrahydro-pyrrolo [1, 2-a] – pyrazine-7-carboxylic acid (200 mg, 0.67 mmol), 3-chloro-4-fluorobenzylamine (0. 16 g, 1.00 mol), and benzotriazol-l-yloxy-tris (dimethylamino) phosphonium hexafluorophophate (BOP, 0.35 g, 0.79 mmol) in anhydrous dichloromethane (10 mL), diisopropylethylamine (0.17 g, 1.33 mmol) was added. The resultant solution was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum, and the residue partitioned between dichloromethane and aq HC1. The organic extract was washed with aq sodium bicarbonate, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to provide the titled amide. 1H NMR (400 MHz, CDC13) 8 7.47 (br d, J = 7.5 Hz, 2H), 7. 32-7 18 (m), 7.01 (br d, 2H), 5.35 (s, 2H), 4.33 (d, J = 6.1 Hz, 2H), 4.14 (q, J = 5.7 Hz, 2H), 3.67 (t, J = 5.7 Hz, 2H), 3.14 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-fluorobenzylamine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2005/41664; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 72235-56-4, A common heterocyclic compound, 72235-56-4, name is 3-Chloro-4-fluorobenzylamine, molecular formula is C7H7ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 50 mL shaker vessel was added 2,6-dimethoxy-4- polystyrenebenzyloxy-benzaldehyde (DMHB resin) (2 g, 1.5 mmol/g, 3 mmol) and 25 mL of NMP. 3-Chloro-4-fluorobenzylamine (1.92 g, 12 mmol), HOAc (2.5 mL, 10%), and Na (OAc) 3BH (3.18 g, 15 mmol) were then added. The mixture was shaken at rt for overnight. The resutling resin was washed with NMP (25 mL x 2), DCM (25 mL x 2), MeOH (25 mL x 2) and DCM (25 mL x 2) and dried in vacuum oven at 35 C for overnight to yield DMHB resin-bound 3-chloro-4- fluorobenzylamine.

The synthetic route of 72235-56-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/87236; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

72235-56-4, These common heterocyclic compound, 72235-56-4, name is 3-Chloro-4-fluorobenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 3-[(3-chloro-4-fluorobenzyl)amino]-1-propanesulfonic acid To a solution of 3-chloro-4-fluorobenzy]amine (1.0 g, 7.8 mmol) in Acetone (2 mL) and Toluene (2 mL) was added 1,3-propane sultone solution (1.5 M in THF, 4.0 mL, 6.0 mmol). The solution was stirred at reflux for 4 hours. The reaction mixture was cooled to room temperature. The solid material was collected by filtration and washed with acetone (2*5 mL) and dried in a vacuum oven at 50 C., affording the title compound, 0.041 g (2%). 1H NMR (D2O, 300 MHz) delta ppm 7.44 (dd, 1H, J=2.2 Hz, 6.9 Hz), 7.25 (m, 1H), 7.15 (t, 2H, J=8.6 Hz), 4.07 (s, 2H), 3.07 (t, 2H, J=7.8 Hz), 2.83 (t, 2H, J=7.5 Hz), 1.98 (m, 2H). 13C (D2O, 75 MHz) delta ppm 160.07, 156.77, 132.18, 130.43, 130.22, 127.90, 120.94, 117.58, 117.29, 50.20, 48.17, 46.09, 21.67. 19F (D2O, 282 MHz) delta ppm -115.33. ES-MS 280 (M-1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 72235-56-4.

Reference:
Patent; Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Bellini, Francesco; US2006/183800; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics