Category: 72934-36-2

Adding a certain compound to certain chemical reactions, such as: 72934-36-2, name is 1-(4-Chlorophenyl)cyclopropanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72934-36-2, Computed Properties of C9H10ClN

To a slurry of tert-butyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate (3.6 g) and 1-(4-chlorophenyl)cyclopropanamine (1.49 g) in THF (50 mL) was stirred for 5 hours at 80 C. The precipitate was filtrated through a plug washing with THF to give acrude product that was purified by Biotage eluting with 4/1-hexane/ethyl acetate to give 1.8 g of tert-butyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate as a solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Wang, Tao; Yin, Zhiwei; Scola, Paul Michael; US2014/134130; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

72934-36-2, name is 1-(4-Chlorophenyl)cyclopropanamine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H10ClN

To a slurry of tert-butyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-l,3,5-triazin-2- ylamino)benzoate (3.6 g) andl-(4-chlorophenyl)cyclopropanamine (1.49 g) in THF (50 mL) was stirred for 5 hours at 80C. The precipitate was filtrated through a plug washing with THF to give acrude product that was purified by Biotage eluting with 4/1-hexane/ethyl acetate to give 1.8 g of tert-butyl 4-(4-(l-(4- chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-l,3,5-triazin-2- ylamino)benzoate as a solid.

The synthetic route of 72934-36-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; ZHANG, Zhongxing; HAN, Ying; YIN, Zhiwei; SCOLA, Paul Michael; WO2014/116768; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 72934-36-2, These common heterocyclic compound, 72934-36-2, name is 1-(4-Chlorophenyl)cyclopropanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a slurry of tert-butyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate (3.6 g) and 1-(4-chlorophenyl)cyclopropanamine (1.49 g) in THF (50 mL) was stirred for 5 hours at 80 C. The precipitate was filtrated through a plug washing with THF to give acrude product that was purified by Biotage eluting with 4/1-hexane/ethyl acetate to give 1.8 g of tert-butyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate as a solid.

Statistics shows that 1-(4-Chlorophenyl)cyclopropanamine is playing an increasingly important role. we look forward to future research findings about 72934-36-2.

Reference:
Patent; Bristol-Myers Squibb Company; Wang, Tao; Scola, Paul Michael; Zhang, Zhongxing; Yin, Zhiwei; Zhao, Qian; US2013/203758; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 72934-36-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72934-36-2 as follows.

Step 3: iPr2NEt (0.35 g) was added into the solution of methyl 4-(4-chloro-6-(2,2,2- trifluoroethoxy-D2)- 1,3,5 -triazin-2-ylamino)benzoate (1 g) and 1 -(4- chlorophenyl)cyclopropanamine (0.46 g) in THF (15 mL). The reaction was stirred at70C for 16 hours. Solvents were removed under vacuum to give a residue, to which 100 ml of EtOAc were added. The organic phase was washed with water (2 x 20 mL) and brine (15 mL), dried over Mg504 and concentrated under vacuum to give methyl 4-(4-(1- (4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)- 1,3 ,5-triazin-2- ylamino)benzoate (1.30 g) which was used in the further reaction without purification.

According to the analysis of related databases, 72934-36-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WANG, Tao; YIN, Zhiwei; ZHANG, Zhongxing; SCOLA, Paul Michael; WO2014/116766; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 72934-36-2, name is 1-(4-Chlorophenyl)cyclopropanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72934-36-2, Recommanded Product: 72934-36-2

To a stirred solution of 1 -benzyl 3 -((3aR ,5aR ,5bR ,7aR ,95, 11 aR, 1 ibR, 1 3a5)-3a-iso cyanato- 1 -isopropyl-5a,5b,8,8, 11 a-pentamethyl-2-oxo-3 ,3a,4,5,5a,5b,6,7,7a,8,9, 10,11,11 a, 1 ib, 12,13,1 3a-octadecahydro-2H-cyclopenta[ajchrysen-9-yl) (1R,35)-2,2-dimethylcyclo butane-i,3-dicarboxylate (Intennediate-2, 3.0 g, 4.213 mmol, 1.0 eq) in THF (30 ml) wasadded DIPEA (2.16 ml, 12.64 mmol, 3.0 eq) followed by i-(4-chlorophenyl)cyclopropan-i- amine (Intennediate-4, 0.847 g, 5.056 mmol, 1.2 eq). The reaction mixture was stirred at room temperature for about 16 hours. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was diluted with water (75 ml) andextracted with ethyl acetate (3×75 ml). The combined organic extracts were washed with water (75 ml) and brine solution (50 ml). The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by silicagel column chromatography by using 0-2% methanol in dichloromethane gradient. The fractionscontaining the expected product were combined and concentrated under reduced pressure to give the desired product (3.0 g, 80.9% yield) as a white solid. ?H NMR (300 MHz, CDC13): ppm 7.37-7.34 (m, 5H), 7.30 (d, J = 8.7 Hz, 2H), 7.13 (d, J = 8.7 Hz, 2H), 5.16, 5.10 (ABq, JAB= 12.3 Hz, 2H), 5.09 (s, 1H), 4.76 (s, 1H), 4.44 (dd, J= 11.4, 4.8 Hz, 1H), 3.18-3.07 (m, 1H), 2.87-2.57 (m, 5H), 2.20 (d, J = 18.3 Hz, 1H), 2.14-1.98 (m, 2H), 1.91-1.80 (m, 2H),1.80-1.61 (m, 4H), 1.56-1.39 (m, 4H), 1.39-1.25 (m, 6H), 1.34 (s, 3H), 1.22 (s, 3H), 1.19 (s,3H), 1.17-1.0 (m, 4H), 0.97 (s, 3H), 0.91 (s, 3H), 0.88 (s, 3H), 0.85 (s, 6H), 0.79 (m, 1H),0.75 (s, 3H); ESI-MS: mlz 901.46 (M+Na)t

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; KASIREDDY, Bhaskar Reddy; (84 pag.)WO2017/64628; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

72934-36-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72934-36-2 name is 1-(4-Chlorophenyl)cyclopropanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a slurry of tert-butyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate (3.6 g) and 1-(4-chlorophenyl)cyclopropanamine (1.49 g) in THF (50 mL) was stirred for 5 hours at 80 C. The precipitate was filtrated through a plug washing with THF to give a crude product that was purified by Biotage eluting with 4/1-hexane/ethyl acetate to give 1.8 g of tert-butyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate as a solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Chlorophenyl)cyclopropanamine, and friends who are interested can also refer to it.

Reference:
Patent; WANG, TAO; Yin, Zhiwei; Scola, Paul Michael; US2014/135335; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

72934-36-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72934-36-2 name is 1-(4-Chlorophenyl)cyclopropanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate (0.93 g, 2.45 mmol) in THF (10 mL) was added 1-(4-chlorophenyl)cyclopropanamine (0.5 g, 2.45 mmol) and Hunig’s Base (1.71 mL, 9.8 mmol). The resulting mixture was refluxed at 80 C. for 16 hs. The precipitate was filtrated through a plug washing with THF to give a crude product that was purified by Biotage eluting with 4/1 to 3/2 hexane/ethyl acetate to give 1.2 g of methyl 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoro ethoxy)-1,3,5-triazin-2-ylamino)-3-fluorobenzoate as product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Chlorophenyl)cyclopropanamine, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; Wang, Tao; Scola, Paul Michael; Zhang, Zhongxing; Yin, Zhiwei; Zhao, Qian; US2013/203758; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics