Category: 729590-57-2

Electric Literature of 729590-57-2,Some common heterocyclic compound, 729590-57-2, name is 4-(Benzyloxy)-1-bromo-2-chlorobenzene, molecular formula is C13H10BrClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step-2: Synthesis of 4-(benzyloxy)-l-(but-l-yn-l-yl)-2-chlorobenzene sealed tube/90 “C/12 h To a stirred solution of 4-(benzyloxy)-l-bromo-2-chlorobenzene (13 g, 43.91 mmol) in 130 mL of DMA in a sealed tube, were added copper iodide (0.833 g, 4.39 mmol) and cesium carbonate (28.63 g, 87.83 mmol) at room temperature. This mixture was degassed with three vacuum/N2 cycles, and were added but-l-yn-l-yltrimethylsilane (11 g, 87.83 mmol, Example-16, Step-2) followed by Pd(OAc)2 (1.079 g, 4.39 mmol) and dppf (2.4 g, 4.39 mmol). The pressure tube was sealed and heated at 90 C for 12 h. Upon completion by TLC, the reaction mixture was diluted with water (250 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were washed with water, brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product was purified over 230-400 mesh silica gel column chromatography using 3% EtOAc in n-hexane to afford 4-(benzyloxy)-l-(but-l-yn-l-yl)-2-chlorobenzene (9.4 g, 80%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Benzyloxy)-1-bromo-2-chlorobenzene, its application will become more common.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; (161 pag.)WO2016/196342; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 729590-57-2, name is 4-(Benzyloxy)-1-bromo-2-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 729590-57-2

Step B; 3-chloro-4-ethylacrylate-benzyloxyphenol; Ethyl acrylate (5.0 mL, 55.5 mmol) is added to a solution of 4-bromo-3- chlorobenzyloxyphenol (2.7 g, 9.08 mmol), palladium acetate (215 mg, 0.96 mmol), P (o- tol) 3 (550 mg, 1.8 mmol) and Et3N (3 mL, 21.5 mmol) in EtCN (100 mL, HPLC grade). The mixture is warmed to 95C and stirred at that temperature overnight (c. a. 16 h). It is allowed to reach r. t. , filtered trough Celite and partitioned between EtOAc and H20. The organic layer is dried, filtered and concentrated, and the resulting crude is flash chromatographed on Si02 (5% EtOAc/hexanes) to afford 1.79 g of the Heck product (62%, white solid).

The synthetic route of 729590-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/66136; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics