Category: 73006-78-7

Reference of 73006-78-7,Some common heterocyclic compound, 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine, molecular formula is C12H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General Method A: Synthesis of an isocyanate from an aniline To a solution of the aniline (5.21 mmol, 1.00 equivalent) in toluene (19.0 ml), triphosgene (0.35 equivalents) is added slowly and the reaction mixture is heated to reflux for 1 h. The reaction mixture is concentrated to dryness and the product is either purified by bulb-to-bulb distillation or used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-[1,1′-biphenyl]-2-amine, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BUETTELMANN, Bernd; CECCARELLI, Simona M.; CONTE, Aurelia; KUEHNE, Holger; KUHN, Bernd; NEIDHART, Werner; OBST SANDER, Ulrike; RICHTER, Hans; WO2014/146994; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 73006-78-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

250 mL under a stream of nitrogenCompound 2-A (6.0 g, 29.46 mmol) in flask,1-naphthalene boronic acid (6.08 g, 35.35 mmol),Potassium triphosphate (15.63 g, 73.65 mmol),Palladium (II) acetate (0.198 g, 0.884 mmol),2-dicyclohexylphosphino-2 ‘, 6′-dimethoxybiphenyl (0.726 g, 1.767 mmol), toluene (100 mL) and H2O (10 mL) were added thereto, and the mixture was stirred and refluxed.After completion of the reaction, the toluene layer was extracted using toluene and water. The extracted solution was treated with MgSO 4 to remove residual water, concentrated under reduced pressure, and purified by column chromatography to give a compound 2-B.6.16 g was obtained in 70.8% yield.

The synthetic route of 5-Chloro-[1,1’-biphenyl]-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Material Science Co.,Ltd.; Lee Tae-wan; Huh Jeong-hoe; Lee Dong-hun; Park Seong-min; Kim Seon-jae; Kim Seong-hun; (44 pag.)KR102041137; (2019); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 73006-78-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: (B) Under a nitrogen atmosphere, a 100 mL Schlenk flask was charged with 4′-(tert-butyl)-[1,1′-biphenyl]-2-amine (0.56g, 2.5 mmol) and THF (10 mL) at 0 oC with stirring. Acetic formic anhydride (2 mL), which was prepared from the reaction of acetic anhydride with formic acid (1.1 equiv) at 55 C for 2 h, was added dropwise with syringe. Then, the reaction mixture was warmed to room temperature for 2 h, treated with saturated NaHCO3, and extracted with EtOAc (3 ¡Á 25 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (3:1 (v/v)) as eluents to afford N-(4′-(tert-butyl)-[1,1′-biphenyl]-2-yl)formamide as a yellow oil (0.60 g 95%).

The chemical industry reduces the impact on the environment during synthesis 5-Chloro-[1,1′-biphenyl]-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhao, Cheng-Long; Shi, Jin; Lu, Xiuqiang; Wu, Xun; Zhang, Cheng-Pan; Journal of Fluorine Chemistry; vol. 226; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 73006-78-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under nitrogen or argon, 0.4 mmol, 0.2mmol, Ir(ppy) 3(2mg) and DMF1 ml was added to the reaction flask, followed by blue LED lights(7W) irradiation until complete conversion of trivalent iodine reagent completion of thereaction at room temperature. Add 10 ml of saturated Na 2CO 3Aqueous solution, andextracted three times with ethyl acetate, the organic layer was washed with water andonce with saturated brine, dried over anhydrous Na 2SO 4The organic layer was dried.Column chromatography (eluent: petroleum ether 60-90: ethyl acetate = 20: 1-10: 1) to give the product in 48% yield

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-[1,1′-biphenyl]-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing University; Zhu, ChengJian; Xie, jin; Xu, Pan; (13 pag.)CN103553857; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

73006-78-7, The chemical industry reduces the impact on the environment during synthesis 73006-78-7, name is 5-Chloro-[1,1′-biphenyl]-2-amine, I believe this compound will play a more active role in future production and life.

A mixture of the product from step (i) (0.94g), sodium acetate (0.5g) and tert- butylbromoacetate (0.6ml) in ethanol (20ml) was heated under reflux for 5h. A further porton of sodium acetate (Ig) and tert-butylbromoacetate( 1.2ml) was added and the mixture heated under reflux overnight. The solvent was evaporated under reduced pressure and the residue partitioned between ethyl acetate and water, the organic layer was washed with water, dried, and the solvent evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% ethyl acetate/isohexane, yield 0.775g. MS: APCI (-ve) 260 (M-l-tBu)

The chemical industry reduces the impact on the environment during synthesis 5-Chloro-[1,1′-biphenyl]-2-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/37982; (2006); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics