Category: 74672-01-8

Hodgson, H. H.; Wignall, J. S. published an article in 1927, the title of the article was Nitrosation of phenols. IV. 3,5-Dichlorophenol.COA of Formula: C7H5Cl2NO3 And the article contains the following content:

cf. C. A. 20, 3449. Nitration of 16 g. 3,5-Cl2C6H3OH with NaNO3 and dilute H2SO4 gives 5 g. 3,5-dichloro-2-nitrophenol (I), lemon-yellow, m. 51°, volatile with steam, does not give a solid Ac derivative, and 6 g. 3,5,4-Cl2(O2N)C6H2OH (II), m. 150°, whose acetate, m. 99°. The action of HNO2 on 3,5-Cl2C6H3OH gives II. Reduction of I gives the 2-amino derivative, m. 132°; the 4-amino derivative; m. 154°; the 2 isomers give reddish brown and violet colors with FeCl3. I or II, with Me2SO4, gives 70% of the corresponding anisoles, m. 75° and 70°, resp. 3,5-Dicloro-4-aminoanisole, m. 71°. 3,5-Dichloro-4-nitrosoanisole, m. 125°, results by oxidation of the NH2 derivative with Caro’s acid; it turns green on melting but becomes colorless on cooling; heating with concentrated H2SO on the H2O bath for 0.5 hr. gives 3,5-dichloro-4-nitrosophenol [quinone-4-oxime (?) ], decomposes 165°; boiling acids decompose it. Reduction of 3,4-Cl(O2N)C6H3OMe with Sn and HCl gives 3,5,4-Cl2(H2N)C5H2OMe. 3-Chloro-4-nitrosoanisole, deep green, m. 59°, results when the HCl salt of the 4-NH2 derivative is oxidized with K2S2O5 in AcONa solution 3,5-Dichloro-4-nitrodimethylaniline, golden, m. 142°, results from NaNO2 in HCO2H or from HNO3-H2SO4 at 0°. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).COA of Formula: C7H5Cl2NO3

1,5-Dichloro-3-methoxy-2-nitrobenzene(cas:74672-01-8) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. COA of Formula: C7H5Cl2NO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Holleman, A. F.; van Haeften, F. H. published an article in 1921, the title of the article was Replacement of substituents in the benzene ring. V. The six trichloronitrobenzenes and the three trinitrobenzenes; their reaction with sodium methylate.Computed Properties of 74672-01-8 And the article contains the following content:

Preparation of the 6 trinitrobenzenes. The 6 isomers are already described in the literature but the method of preparation was improved in several instances and the details are here given. Qualitative results on the action of NaOMe on the trichloronitrobenzenes. The methods used in this reaction were described previously (C. A. 15, 65). In this case the reaction is much slower than with the dichlorodinitrobenzenes so that heating some hrs. on the H2O bath is necessary. 15 g. 2,3,4-Cl3C6H2NO2 (A) after heating with 105 cc. 0 4755 N NaOMe solution 5 hrs. in an autoclave at 110° were poured into H2O and filtered. The product was distilled with steam and on crystallization from EtOH gave 3,4,2-Cl2(O2N)C6H6OMe, silky needles, m. 72.5°, identical with that obtained by d. Hollander (C. A. 15, 65). 5 g. 3,4,5-Cl3C6H2NO2 (B) heated 6 hrs. under a condenser on the H2O bath with 52 cc. NaOMe (0.47 N) gave after evaporating most of the MeOH and pouring into H2O a solid which from EtOH gave silky needles with a green reflex, m. 98°, identical with the Cl2(O2N)C6H2OMe obtained by d. H. (l. c.) from 1,3,2,5-C6H2Cl2(NO2)2. 20 g. 2,5,6-C3C6H2NO2 (C) were heated with 210 cc. NaOMe (0.47 N) 24 hrs. on a H2O bath under a condenser and after evaporating most of the MeOH the mixture was poured into H2O and filtered. The oil separated was distilled with steam and gave colorless crystals of 3,4,2-Cl2(O2N)COH2OMe, m. 128°. The main portion gave crystals of 2,5,6-Cl3C6H2OMe, m. 42.8°. 5 g. 2,4,5-Cl3C6H2NO2 (D) were heated with 52 g. NaOMe (0.47 N) for 6 hrs. on the H2O bath and gave a 2,5,4- Cl2(O2N)C6H2OMe, m. 101°, identical with that obtained from 1,4,2,5-C6H2Cl2(NO2)2. Beilstein and Kurbatow (Ann. 192, 23(1878)) found that with NH3 the Cl ortho to the NO2 group is replaced. 2,3,5-Cl3C6H2NO2 (E) with NaOMe gave the same anisole, m. 44°, obtained by d. H. from 1,3 5,6-C6H2Cl2(NO2)2. 6 g. 2,4,6-Cl3C6N2O2 (F) heated 6 hrs. with 65 cc. NaOMe on the H2O bath gave an anisole, m. 72.5°, which by arguments based on analogy is said to be 2,4,6-Cl2(MeO)C6H2NO2. Quantitative researches. The methods used were the same as those used by d. H. (l. c.) and the numerical results are given in table. Discussion of results. The numerical results are summarized in several tables. The reaction constants at 0 ° of chloronitrobenzenes, dichloronitrobenzenes, trichloronitrobenzenes and chlorodinitrobenzenes increase in the same order. The Cl atom which leaves the ring is always o- or P- with respect to the NO2 group. In each group of isomers the largest constant of reaction is obtained for that compound in which the Cl atom which leaves is in the P-position with respect to the NO2 group which it renders mobile. When another Cl atom is placed o- or p- to the Cl atom which leaves the mobility of the latter is increased. The conclusion of d. H. (l. c.) that in m-C6H4(NO2)2, m-ClC6H4NO2 and sym-Cl2C6H3NO2, which are inert toward NaOMe, any of the substituents is rendered mobile by the introduction of a NO2 group or a Cl atom, was fully confirmed. When one introduces a substituent it is always this which reacts with NaOMe. C and F showed the smallest velocity of reaction. The same is true of 2,6-Cl2C6H3NO2, showing that a NO2 group placed between 2 adjacent Cl atoms determines a very slow velocity of substitution. The fact that the velocity with C is less than with F shows that the presence of 3 Cl atoms adjacent diminishes the liberating activity of a NO2 group. The examination of the products of the transformation of C with NaOMe shows that in this isomer the NO2 group is changed in character. Comparison of the results for isomers of Cl2C6H3NO2 and Cl3C6H2NO2 shows that the latter behave more like Cl2C6H3NO2 derivatives than like Cl3C6H2NO2 derivatives The quant. conclusions are among the parts of the paper that cannot be adequately abstracted. Preparation of isomeric trinitrobenzenes. The details of the preparation of the 1,2,4-(G), 1,2,3- (H), and 1,3,5-trinitrobenzenes (I) are given here, although all were previously known. 5 g. H with 55 cc. 0.47 N NaOMe reacted at room temperature and after 0. 5 hr. on the H2O bath and after standing 24 hrs. separated 2,6-(O2N)2C6H8OMe, m. 118°. 5 g. G treated similarly gave 2,4-(O2N)2C6H8OMe, m. 88°. 5 g. I treated similarly gave 3,5-(O2N)2C63OMe, m. 105°. Data on quant. measurements of the same reactions are given. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Computed Properties of 74672-01-8

1,5-Dichloro-3-methoxy-2-nitrobenzene(cas:74672-01-8) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Computed Properties of 74672-01-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hodgson, Herbert H.; Batty, Walter E. published an article in 1934, the title of the article was Direct nitration of 5-chloro-3-hydroxy- and of 5-chloro-3-nitroanisole.Quality Control of 1,5-Dichloro-3-methoxy-2-nitrobenzene And the article contains the following content:

5-Chloro-3-hydroxyanisole (I), NaNO3, H2SO4 and H2O give a mixture of the 4-NO2 derivative, m. 106° (volatile with steam), and the 4,6-di-NO2 derivative (II), m. 126°. I and Me2SO4 give 5-chlororesorcinol di-Me ether, m. 38°; HNO3 in Ac2O at room temperature gives the 4-NO2 derivative, m. 123°; twice the quantity of HNO3 gives the 4,6-di-NO2 derivative (III), m. 216°, also obtained from II and Me2SO4. 2,4,6-Cl3C6H2NO2 and MeONa-MeOH, refluxed 4 hrs., give 3,5,2-Cl2(O2N)C6H2OMe, m. 75°; heating at 120° for 1.5 hrs. gives 5-chloro-2-nitroresorcinol di-Me ether (IV), m. 184°; heating 5 hrs. at 150° gives nitrophloroglucinol tri-Me ether, m. 153°; HNO3 gives the di-NO2 derivative (V), m. 166°. IV, HNO3 and Ac2O give the 2,4-di-NO2 derivative, m. 110°. 1,3,5,2,4-Cl3C6H(NO2)2 and MeONa at room temperature for 10 days give III and V. 5-Chloro-3-nitroanisole and HNO3 in H2SO4 give the 3,4,6-tri-NO2 derivative, orange-yellow, m. 128°; with MeONa on the water bath for 10 min. there results III. 3,5-Dichloro-2-nitroanisole and 20% EtOH-KOH, 2 hrs. at 130°, give 5-chloro-2-nitro-3-hydroxyanisole, m. 88°. 5-Chloro-3-hydroxyanisole and HNO3 give the 2,4,6-tri-NO2 derivative, m. 147°. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Quality Control of 1,5-Dichloro-3-methoxy-2-nitrobenzene

1,5-Dichloro-3-methoxy-2-nitrobenzene(cas:74672-01-8) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Quality Control of 1,5-Dichloro-3-methoxy-2-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brown, J. P.; McCall, E. B. published an article in 1955, the title of the article was Some chlorinated hydroxyphenoxyacetic acids.Synthetic Route of 74672-01-8 And the article contains the following content:

Efforts to determine the fate of 2,4-Cl2C6H3OCH2CO2H in plants and in soil substrates led to the present syntheses of various chlorinated (hydroxyphenoxy)acetic acids. A metabolite isolated from cultures of bacteria grown in a medium containing 4-ClC6H4OCH2CO2H [Evans and Smith, Biochem. J. 57, Number 4, xxx(1954)] was believed to be 4,2-Cl(HO)C6H3OCH2CO2H (I), so its synthesis was first undertaken. 4-ClC6H4OCH2CO2H (10 g.) heated 2 h. at 90° with 100 mL. concentrated HNO3 gave 7.0 g. 4,2-Cl(O2N) C6H3OCH2CO2H (II), m. 173-5° (from aqueous MeOH); II (1.0 g.) reduced with Na Na2S2O4 at 90° and acidified to pH 4 gave 0.15 g. white needles, m. 215-18°, and the filtrate boiled with 32% HCl yielded 0.52 g. of the same material. This was the lactam of 4,2-Cl(H2N)C6H3OCH2CO2H, 6-chloro-3,4-dihydro-3-oxobenzoxazine, m. 217-18° (from EtOH). II (5.0 g.)was also boiled in 50 mL. C6H6, with 8.0 mL. SOCl2, 8 h., the C6H6 and excess SOCl2 evaporated, 4.0 g. 20% solution of NHMe2 in C6H6 added to the residue, and the mixture allowed to stand overnight, then concentrated, and filtered, giving 4.7 g. crude 4,2-Cl(O2N)C6H3OCH2CONMe2, m. 84° (100-1° on recrystallization from MeOH), reduced by Fe and HOAc in aqueous EtOH to the 2-H2N analog, m. 121° (from EtOH). Attempts to replace the NH2 group by OH in both the NH2 acid and its dimethylamide failed. 5,2-Cl(HO)C6H3Ac (2.8 g.) boiled 4 h. with 3.2 g. NaOH and 4.7 g. ClCH2CO2H in 30 mL. H2O, cooled, and acidified gave 2.4 g. 4,2-ClAcC6H3COCH2CO2H, m. 177-8° (from aqueous MeOH). Efforts to oxidize this to I were unsuccessful. 4,1,2-ClC6H3(OH)2 (14.8 g.) added to a solution of 2.8 g. Na in 60 mL. dry EtOH and the boiling mixture treated with 3.7 g. ClCH2CO2Et, gave 6.4 g. impure 5,2-Cl(HO)C6H3OCH2CO2H, m. 157° (from H2O), forming with Me2SO4 and hot 20% aqueous NaOH with a Me ether (III), m. 143-5° (from aqueous MeOH). The identity of III was established by first reducing 4-nitroguaiacol with H at room temperature and atm. pressure over Pd-C to the amino compound, converting it to the HCl salt, diazotizing, and adding CuCl to give 4-chloroguaiacol, m. 36-7°, which, allowed to react with ClCH2CO2H in NaOH and H2O 2 h. at 95°, then acidified, gave 5,2-Cl(MeO)C6H3OCH2CO2H, m. 141-3° (from C6H6), identical with III. 4-Nitroguaiacol and ClCH2CO2H condensed in the presence of NaOH to either 2,5-HO(O2N)C6H3OCH2CO2H (IV), m. 191° (from aqueous MeOH), or the 2-MeO analog (V), m. 180-2° (from aqueous MeOH), depending on the concentration of NaOH used. IV reduced, diazotized, and treated with CuCl as above gave 5,2-Cl(HO)C6H3OCH2CO2H, m. 157° (from H2O and aqueous MeOH), and V gave first 5,2-H2N(MeO) C6H3OCH2CO2H, m. 232° (from H2O), and finally 5,2-Cl(MeO)C6H3OCH2CO2H, m. 140-2° (from aqueous MeOH). 5-Nitroguaiacol converted to 5-chloroguaiacol, m. 16-17°, as described above for the 4-Cl compound, then treated with ClCH2CO2H, yielded 4,2-Cl(MeO)C6H3OCH2CO2H, m. 135-6° (from C6H6 or aqueous MeOH), which (0.2 g.), boiled 1 h. with 2.0 mL. 48% aqueous HBr, gave on cooling 0.15 g. I; after recrystallization from H20, slowly I, m. 110° on slow, 124-30° on rapid heating. 5-Nitroguaiacol (2.0 g.) with 1.5 g. ClCH2CO2Et in the presence of NaOMe gave 0.5 g. 2,4-MeO(O2N)C6H3OCH2CO2Et, m. 88-91° (from MeOH). 3,5,1,2-Cl2C6H2,(OH)2 and ClCH2CO2Et gave 2,4,6-Cl2(HO)C6H2OCH2CO2H (VI), m. (depending on the rate of heating) 130-55° (after recrystallization from H2O), identical with the substance prepared by Cavill and Ford (C.A. 49, 3072h). Its Me ether, m. 174-6°. 2,4-Cl2C6H3OH nitrated with concentrated HNO3 at 30-40° to 2,4,6-Cl2(O2N)C6H2OH, m. 122-4°, then reduced in alk. Na2S2O4, neutralized with HOAc, and the resulting aminophenol acetylated with Ac2O yielded 4,6,2-Cl2(AcNH)C6H2OH, m. 138-40° (from aqueous EtOH), which, boiled 6 h. in acetone with MeI and K2CO3, formed 4,6,2-Cl2(AcNH)C6H2OMe, m. 112-14° (from light petroleum, b. 60-80°), hydrolyzed by boiling 1 h. in 20% HCl to 4,6,2-Cl2(H2N)C6H2OMe.HCl, m. 196° (from dilute HCl), converted with NaOH to the amine, f.p. 16°. The amine diazotized and the diazonium solution added to CuSO4 in H2O with simultaneous passage of steam yielded from the steam distillate 4,6-dichloroguaiacol, m. 63-4° (from light petroleum, b. 60-80°), converted in the usual way into 3,5,2-Cl2(MeO)C6H2OCH2CO2H, m. 106-7° (from PhMe). The MeO acid, boiled 1 h. with 48% HBr gave 3,5,2-Cl2(HO)C6H2OCH2CO2H, m. 154° (from H2O). 2,4-Cl2C6H3NH2 (12 g.) in 450 mL. acetone and 700 mL. H2O containing 11 g. KOH treated during 5 h. at 25° with 20 g. K2S2O8 in 450 mL. H2O gave only 1.5 g. product which, boiled with 20% HCl, basified with NaHCO3, and Ac2O added yielded 0.4 g. 3,5,2-Cl2(AcNH)C6H2OH, m. 190-3° (from aqueous MeOH), methylated with MeI to 3,5,2-Cl2(AcNMe)C6H2OMe (VII), m. 107-9° (from light petroleum, b. 60-80°). This route to 3,5-dichloroguaiacol was abandoned, though, because of the poor yields in these 2 steps. When 9.0 g. 5-chlorovanillic acid in 90 mL. glycerol containing 0.2 g. Cu bronze was heated 10 min. at 250-60°, and steam was passed through the mixture, 1.7 g. 3-chloroguaiacol, m. 54° (from light petroleum, b. 60-80°) was recovered from the distillate; a C6H6 solution of this compound did not react with SO2Cl2 at room temperature, and boiling with a large excess of SO2Cl2 gave a mixture from which 5% of a trichloroguaiacol, m. 102-4° (from light petroleum, b. 60-80°) was isolated. 5-Chlorovanillic acid (5.0 g.) was dissolved in 30 mL., warm concentrated H2SO4, 50 mL. CHCl3 added, and the mixture stirred at 45° while 2.5 g. NaN3 was added during 30 min., then poured onto ice, and filtered. If the filtrate was basified at this point, it gave a rapidly discoloring precipitate of 5-amino-3-chloroguaiacol which could be converted by the addition of Ac2O into 5-acetamido-3-chloroguaiacol, m. 165° (from H2O). To obtain 3,5-dichloroguaiacol, the filtrate was treated with BaCl2 solution to remove the sulfate, and the remaining amine hydrochloride solution diazotized and treated with urea and a solution of CuCl2; steam distillation, extraction with Et2O, and vacuum-distillation gave 0.3 g. material, b15 170° (bath temperature), which, recrystallized 3 times from light petroleum (b. 60-80°), gave 3,5-dichloroguaiacol (VIII), m. 64-5°, also obtained from 2,4,6-Cl3C6H2NO2 by condensation with NaOMe to 3,5,6-Cl2(O2N)C6H2OMe, m. 70-2° (from EtOH) and reduction with H (Raney Ni) to 3,5,2-Cl2(H2N)C6H2OMe (IX). Acetylation of IX gave the N-Ac derivative, m. 169.5-71.5° (from PhMe), and methylation gave VII. IX in concentrated H2SO4 converted into VIII as described in the diazotization of the 4,6-Cl2 isomer. VIII (0.6 g.) yielded in the usual way 0.7 g. VI, identical with the acid from 3,5,1,2-Cl2C6H2(OH)2. 2-ClC6H3OCH2CO2H boiled with concentrated HNO3 5 min. gave the 4-O2N derivative, m. 179-81° (from aqueous EtOH), esterified with MeOH and. concentrated H2SO4 to the Me ester, m. 124°. Hydrogenation of the ester in MeOH over Pd gave 2,4-Cl(H2N)C6H3OCH2CO2Me, m. 69° (from petr. ether, b. 60-80°), which was diazotized, added to CuSO4 in boiling H2O, the product extracted with Et2O, dissolved in NaOH, precipitated with acid, dried, treated with boiling C6H6, and the fraction insoluble in C6H6 recrystallized twice from H2O to give 2,4-Cl(HO)C6H3O CH2 CO2H acid (X), m. 146-7° [Me ether, m. 136-8° (from PhMe)]. Another synthesis of X involved chlorinating p-MeOC6H4OH with SO2Cl2 to 2,4-Cl(MeO)C6H3OH, b15 108°, m. 46-7° (from petr. ether, b. 60-80°), and converting this in the usual way to a phenoxyacetic acid, which was identical with the above 2,4-Cl(MeO)C6H3OCH2CO2H and on boiling with 48% HBr gave X. A bacterial metabolite of 2,4-Cl2C6H3OCH2CO2H has been isolated by Evans which is not identical with any of the hydroxyphenoxyacetic acids described above. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Synthetic Route of 74672-01-8

1,5-Dichloro-3-methoxy-2-nitrobenzene(cas:74672-01-8) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Synthetic Route of 74672-01-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 30, 1980, Ried, Walter; Sell, Gunther published an article.Name: 1,5-Dichloro-3-methoxy-2-nitrobenzene The title of the article was Anomalous reaction of a 3-chloro-2-nitroanisole. And the article contained the following:

The anisole I reacts with PhNH2 with cleavage of the ether linkage to form the hydroxydiphenylamine II. The latter underwent condensation with EtO2CCH2COCl hydrogenation, and treatment with HCl to give a benzodiazepinedione derivative The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Name: 1,5-Dichloro-3-methoxy-2-nitrobenzene

The Article related to chloronitroanisole aniline substitution cleavage, anisole chloronitro substitution cleavage, benzodiazepinedione chlorodihydrohydroxyphenyl, Physical Organic Chemistry: Cleavage and Additive Reactions and other aspects.Name: 1,5-Dichloro-3-methoxy-2-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 1, 2011, Joshi, S. N.; Vyas, S. M.; Duffel, M. W.; Parkin, S.; Lehmler, H.-J. published an article.Recommanded Product: 1,5-Dichloro-3-methoxy-2-nitrobenzene The title of the article was Synthesis of sterically hindered polychlorinated biphenyl derivatives. And the article contained the following:

A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2/2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed Crystal structure anal. of four PCB derivatives revealed solid state dihedral angles ranging from 69.7° to 81.0°, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Recommanded Product: 1,5-Dichloro-3-methoxy-2-nitrobenzene

The Article related to biphenyl polychlorinated preparation suzuki ullmann, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 1,5-Dichloro-3-methoxy-2-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 1999, Waterhouse, Ian published an article.Safety of 1,5-Dichloro-3-methoxy-2-nitrobenzene The title of the article was Synthesis of deuterium labelled 4′-hydroxydiclofenac. And the article contained the following:

Diclofenac is a potentially useful substrate for the study of drug-drug interactions caused by modulation of the activity of specific isoforms of cytochrome P 450. The synthesis of deuterium labeled 4′-hydroxydiclofenac I, a deuterated analog of a metabolite of diclofenac, is described for use as an internal standard in LC-MS-MS studies. The experimental process involved the reaction of 1,5-Dichloro-3-methoxy-2-nitrobenzene(cas: 74672-01-8).Safety of 1,5-Dichloro-3-methoxy-2-nitrobenzene

The Article related to deuterium labeled hydroxydiclofenac preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 1,5-Dichloro-3-methoxy-2-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics