Category: 7476-66-6

Synthesis and central nervous system depression properties of 3-[(1′-pyrazolyl)phenyl]sydnones was written by Havanur, Shambhuling B.;Badami, Bharati V.;Puranik, Gurubasav S.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1981.HPLC of Formula: 7476-66-6 This article mentions the following:

Sydnones I [R = R² (R³ = H, Me); R¹ = H, Me, Ph] were prepared by the reaction of 2-RC₆H₄NH₂ and ClCHR¹CO₂Me and subsequent nitrosation and cyclization of 2-RC₆H₄NHCHR¹CO₂H. I [R = R² (R³ = H), R¹ = H] had central nervous system depressant activity and considerable toxicity. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6HPLC of Formula: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions of perfluoroalkanesulfonyl chlorides with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex was written by Kamigata, Nobumasa;Udodaira, Kumiko;Shimizu, Toshio. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 1997.Product Details of 7476-66-6 This article mentions the following:

Reactions of trifluoromethane- and tridecafluorohexanesulfonyl chlorides with silyl enol ethers have been investigated in the presence of a ruthenium(II) phosphine complex. Perfluoroalkylation and chlorination occurred depending on the substituent on the silyl enol ether, i.e., perfluoroalkylated compound was selectively obtained in the reactions with silyl enol ether possessing an electron-withdrawing group while chlorinated compounds were selectively formed in the reaction with a silyl enol ether possessing an electron-donating group. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Product Details of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity of functionalized arylcarbenes. 2-Phenylethyl side chains and hetero analogs was written by Kirmse, Wolfgang;Konrad, Wolfgang;Ozkir, Ismail S.. And the article was included in Tetrahedron in 1997.SDS of cas: 7476-66-6 This article mentions the following:

Phenylcarbenes with -X-CH₂Ph and -CH₂X-Ph (X = CH₂, O, SiMe₂) groups in the ortho position were generated thermally and photolytically from diazo or tosylhydrazone precursors. Stereorandom insertion reactions with 尾-C-H bonds were observed, pointing to a triplet abstraction-recombination mechanism. Large kinetic and stereochem. deuterium isotope effects support this notion. The ample formation of benzocyclobutenes from 2-CH₂-X-Ph substrates is due to insertion of the carbenes into ArCH₂-X bonds. Addition to the terminal Ph groups competes with C-H and C-X insertion. The results of benzophenone sensitization and of trapping with methanol suggest that the intramol. reactions of functionalized arylcarbenes proceed, at best, competitively with spin inversion. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6SDS of cas: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Inhibition of biofilm formation by amphiphilic star polymer coatings was written by Totani, Masayasu;Lan, Xiuwan;Wu, Jianfeng;Xi, Chuanwu;Kuroda, Kenichi;Ando, Tsuyoshi;Terada, Kayo;Hirohara, Shiho;Tanihara, Masao. And the article was included in PMSE Preprints in 2012.Synthetic Route of C9H9ClO2 This article mentions the following:

Bacterial infections related to medical implants are a significant problem, causing serious complications after surgery and may lead to implant failure. These infections are associated with adhesion of bacteria to and colonization on implant surfaces, resulting in biofilm formations. Hydrophilic surfaces as a result of polymer coatings have shown potential in preventing biofilm formation. To that end, we have demonstrated a new strategy to prepare implant surfaces with a high d. of hydrophilic polymers utilizing star polymer architectures. The synthesis of these star polymers contain both hydrophilic [poly(2-hydroxyethyl methacrylate)] and hydrophobic [poly(Me methacrylate)] arms will be described. Addnl., results of the anti-biofilm activity against Escherichia coli by these polymer coatings will be presented. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Synthetic Route of C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Systematic Evaluation of Sulfoxides as Catalysts in Nucleophilic Substitutions of Alcohols was written by Motsch, Sebastian;Schuetz, Christian;Huy, Peter H.. And the article was included in European Journal of Organic Chemistry in 2018.Safety of Methyl 2-chloro-2-phenylacetate This article mentions the following:

Herein, a method for the nucleophilic substitution (S_N) of benzyl alcs. yielding chloro alkanes is introduced that relies on aromatic sulfoxides as Lewis base catalysts (down to 1.5 mol-%) and benzoyl chloride (BzCl) as reagent. A systematic screening of various sulfoxides and other sulfinyl containing Lewis bases afforded (2-methoxyphenyl)methyl sulfoxide as optimal catalyst. In contrast to reported formamide catalysts, sulfoxides also enable the application of plain acetyl chloride (AcCl) as reagent. In addition, it was demonstrated that weakly electrophilic carboxylic acid chlorides like BzCl promote Pummerer rearrangement of sulfoxides already at room temperature This side-reaction also provided the explanation, why sulfoxide catalyzed S_N-reactions of alcs. do not allow the effective production of aliphatic and electron deficient chloro alkanes. Comparison experiments provided further insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Safety of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel photocycloadditions of electron-deficient nitrones to 2-methyl-2-butene was written by Sehgal, R. K.;Griffin, G. W.. And the article was included in Liebigs Annalen der Chemie in 1991.Category: chlorides-buliding-blocks This article mentions the following:

Irradiation of (E)-PhN(O):CPhR (I; R = CN, CO₂Me) with Me₂C:CHMe gave oxazolidines in which O became attached to the less substituted terminus of the olefin. The oxazolidines from I (R = CO₂Me) could be isolated, but those from I (R = CN) were more labile and underwent ionization to an oxazolinium ion, followed by nucleophilic attack by CN^– and ring opening, to give PhC(:NPh)OCHMeCMe₂CN. Mechanisms were discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Category: chlorides-buliding-blocks).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chromium(II)-Mediated Reformatskii Reactions of Carboxylic Esters with Aldehydes was written by Wessjohann, Ludger;Gabriel, Tobias. And the article was included in Journal of Organic Chemistry in 1997.Formula: C9H9ClO2 This article mentions the following:

Chromium dichloride reacts with α-halo esters and aldehydes in a Barbier-type reaction to give β-hydroxy esters in good to excellent yield. The reaction is of excellent reproducibility and chemoselectivity and suitable for microscale preparations and the construction of quaternary centers. The simple diastereoselectivity is preferentially anti and contrasts with that of comparable Reformatskii reactions. The effects of substituents, temperature, halogen, and additives are discussed briefly. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Formula: C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scandium triflate-catalyzed transesterification of carboxylic esters was written by Remme, Nicole;Koschek, Katharina;Schneider, Christoph. And the article was included in Synlett in 2007.Safety of Methyl 2-chloro-2-phenylacetate This article mentions the following:

The direct transesterification of carboxylic esters is efficiently catalyzed with Sc(OTf)₃ (10 mol%) in boiling alc. solvent. Me, Et, iso-Pr, and allyl esters were prepared from a broad range of different substrates in high yields. The application of microwave irradiation led to significantly reduced reaction times. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Safety of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclopropanation via the Michael addition was written by Nishiyama, Kazuyoshi;Oda, Junichi;Inouye, Yuzo. And the article was included in Bulletin of the Institute for Chemical Research, Kyoto University in 1974.Application of 7476-66-6 This article mentions the following:

RCH2R1 (R = Ph, R1 = CN) and CH2:C[OP(O)(OMe)2]CO2Me (I) in DMF containing NaH gave cis- and trans-II (R = Ph, R1 = CN) via the RC-R1CH2CH[OP(O)(OMe)2]CO2Me (R = Ph, R1 = CN) intermediate which was formed from the initial Michael adduct, RCHR1CH2C-[OP(O)(OMe)2]CO2Me. The reaction of PhCH2CO2Me with I to give II (R = Ph, R1 = CO2Me) proceeded by the same mechanism. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Halogenated carbonyl ylides in the reactions of mercurial dihalocarbene precursors with substituted benzaldehydes was written by Martin, Charles W.;Lund, Paul R.;Rapp, Erich;Landgrebe, John A.. And the article was included in Journal of Organic Chemistry in 1978.Computed Properties of C9H9ClO2 This article mentions the following:

The reactions of PhHgCBrCl₂ (I) with RC₆H₄CHO [R = H (II), 3-CF₃ (III), 4-MeO (IV)] and 2,4,6-Me₃C₆H₂CHO were studied. Relative reactivities with respect to I were III (0.08), II (0.3), BuCH:CH₂ (0.3), IV (0.9), cyclohexene (1.0), and Me₂C:CMe₂ (15.0). Complexation between I and the aldehyde enhanced the rate of decomposition of I to produce :CCl₂ of the same reactivity as that from I alone. The intermediacy of dichlorocarbonyl ylides was proposed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Computed Properties of C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics