Category: 74788-46-8

Related Products of 74788-46-8,Some common heterocyclic compound, 74788-46-8, name is 1-(4-Chlorophenyl)propan-1-amine, molecular formula is C9H12ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3: 4-amino-N-Q-(4-chlorophenyl)propyl)-l-(7H-pyrrolo[2.,3-dlpyrimidin-4- yl)piperidine-4-carboxamideO-(7-Azabenzotriazol- 1 -yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.209 g) was added in one portion to 4-(tert-butoxycarbonylamino)-l-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperidine-4-carboxylic acid (Intermediate 1) (0.181 g), l-(4- chlorophenyl)propan-l -amine (0.085 g) and DIPEA (0.262 mL) in DMA (10 mL) at 250C under nitrogen. The resulting solution was stirred at 6O0C for 4 hours. The crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using IN ammonia/MeOH and pure fractions were evaporated to dryness. This crude material was then treated with a 20% solution of TFA in DCM (10 mL) and stirred at room temperature for 2 hours. The crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using IN ammonia/MeOH and pure fractions were evaporated to dryness. This material was purified by preparative LCMS using decreasingly polar mixtures of water (containing 1% ammonia) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford 4-amino-N-(l-(4-chlorophenyl)propyl)-l- (7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide as a white solid (0.138 g, 66.8 %).1U NMR (400.13 MHz, DMSOd6) delta 0.87 (3H, t), 1.42 – 1.55 (2H, m), 1.72 – 1.79 (2H, m), 1.91 – 2.05 (2H, m), 2.21 (2H, s), 3.54 – 3.62 (2H, m), 4.38 – 4.45 (2H, m), 4.65 – 4.70 (IH, m), 6.61 (IH, dd), 7.18 (IH, dd), 7.32 – 7.37 (4H, m), 8.31 (IH, d), 8.12 (IH, s). MS m/e MH+ 413.

The synthetic route of 74788-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/47563; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 74788-46-8, name is 1-(4-Chlorophenyl)propan-1-amine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74788-46-8, Product Details of 74788-46-8

B) N-(1-(4-chlorophenyl)propyl)-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide To a mixture of 4-nitrophenyl 2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxylate (300 mg) and 1-(4-chlorophenyl)propan-1-amine (211 mg) in N,N-dimethylformamide (10 mL) was added triethylamine (0.279 mL), and the mixture was stirred at room temperature for 16 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate), and recrystallized from hexane/ethyl acetate to give the title compound (205 mg). MS (API+): [M+H]+345.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Chlorophenyl)propan-1-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIKAMI, Satoshi; NAKAMURA, Shinji; ASHIZAWA, Tomoko; SASAKI, Shigekazu; TANIGUCHI, Takahiko; NOMURA, Izumi; KAWASAKI, Masanori; EP2848618; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

74788-46-8,Some common heterocyclic compound, 74788-46-8, name is 1-(4-Chlorophenyl)propan-1-amine, molecular formula is C9H12ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3: 4-amino-N-Q-(4-chlorophenyl)propyl)-l-(7H-pyrrolo[2.,3-dlpyrimidin-4- yl)piperidine-4-carboxamideO-(7-Azabenzotriazol- 1 -yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.209 g) was added in one portion to 4-(tert-butoxycarbonylamino)-l-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperidine-4-carboxylic acid (Intermediate 1) (0.181 g), l-(4- chlorophenyl)propan-l -amine (0.085 g) and DIPEA (0.262 mL) in DMA (10 mL) at 250C under nitrogen. The resulting solution was stirred at 6O0C for 4 hours. The crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using IN ammonia/MeOH and pure fractions were evaporated to dryness. This crude material was then treated with a 20% solution of TFA in DCM (10 mL) and stirred at room temperature for 2 hours. The crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using IN ammonia/MeOH and pure fractions were evaporated to dryness. This material was purified by preparative LCMS using decreasingly polar mixtures of water (containing 1% ammonia) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford 4-amino-N-(l-(4-chlorophenyl)propyl)-l- (7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide as a white solid (0.138 g, 66.8 %).1U NMR (400.13 MHz, DMSOd6) delta 0.87 (3H, t), 1.42 – 1.55 (2H, m), 1.72 – 1.79 (2H, m), 1.91 – 2.05 (2H, m), 2.21 (2H, s), 3.54 – 3.62 (2H, m), 4.38 – 4.45 (2H, m), 4.65 – 4.70 (IH, m), 6.61 (IH, dd), 7.18 (IH, dd), 7.32 – 7.37 (4H, m), 8.31 (IH, d), 8.12 (IH, s). MS m/e MH+ 413.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 74788-46-8, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/47563; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics