Category: 75279-55-9

Discovery of Highly Potent Liver X Receptor 尾 Agonists was written by Kick, Ellen K.;Busch, Brett B.;Martin, Richard;Stevens, William C.;Bollu, Venkataiah;Xie, Yinong;Boren, Brant C.;Nyman, Michael C.;Nanao, Max H.;Nguyen, Lam;Plonowski, Artur;Schulman, Ira G.;Yan, Grace;Zhang, Huiping;Hou, Xiaoping;Valente, Meriah N.;Narayanan, Rangaraj;Behnia, Kamelia;Rodrigues, A. David;Brock, Barry;Smalley, James;Cantor, Glenn H.;Lupisella, John;Sleph, Paul;Grimm, Denise;Ostrowski, Jacek;Wexler, Ruth R.;Kirchgessner, Todd;Mohan, Raju. And the article was included in ACS Medicinal Chemistry Letters in 2016.COA of Formula: C8H5ClFN This article mentions the following:

Introducing a uniquely substituted Ph sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. The agonist series demonstrated robust LXR尾 activity (>70%) with low partial LXR伪 agonist activity (<25%) in cell assays, providing a window between desired blood cell ABCG1 gene induction in cynomolgus monkeys and modest elevation of plasma triglycerides for agonist I. The addition of polarity to the Ph sulfone also reduced binding to the plasma protein, human 伪-1-acid glycoprotein. Agonist I was selected for clin. development based on the favorable combination of in vitro properties, excellent pharmacokinetic parameters and a favorable lipid profile. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9COA of Formula: C8H5ClFN).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H5ClFN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new derivatives of 5-alkyl-6-(2,6-dihalobenzyl)-2-(methylsulfanyl)pyrimidin-4(3H)-one and the features of their oxidation was written by Novakov, I. A.;Orlinson, B. S.;Navrotskii, M. B.;Eremiichuk, A. S.;Brunilina, L. L.;Gordeeva, E. A.;Gerasimov, E. N.. And the article was included in Russian Journal of Organic Chemistry in 2010.Recommanded Product: 2-Chloro-6-fluorophenylacetonitrile This article mentions the following:

The synthesis and regioselective S-monomethylation of new 5-alkyl-6-(arylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones was investigated. Addnl., the oxidative degradation of these compounds on treatment with H₂O₂-AcOH was studied. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Recommanded Product: 2-Chloro-6-fluorophenylacetonitrile).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 2-Chloro-6-fluorophenylacetonitrile

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) was written by Ali, Abdelselam;Bliese, Marianne;Rasmussen, Jo-Anne M.;Sargent, Roger M.;Saubern, Simon;Sawutz, David G.;Wilkie, John S.;Winkler, David A.;Winzenberg, Kevin N.;Woodgate, Ruth C. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Related Products of 75279-55-9 This article mentions the following:

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives, e.g., I, were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Related Products of 75279-55-9).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 75279-55-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics