Category: 76-83-5

The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly was written by Cole, Andrew G.;Kultgen, Steven G.;Mani, Nagraj;Ardzinski, Andrzej;Fan, Kristi Yi;Thi, Emily P.;Dorsey, Bruce D.;Stever, Kim;Chiu, Tim;Tang, Sunny;Daly, Owen;Phelps, Janet R.;Harasym, Troy;Olland, Andrea;Suto, Robert K.;Sofia, Michael J.. And the article was included in RSC Medicinal Chemistry in 2022.Product Details of 76-83-5 This article mentions the following:

Disruption of the HBV viral life cycle with small mols. that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clin. validated approach to inhibiting HBV viral replication. Herein we report the further optimization of clin. candidate AB-506 through core modification with a focus on increasing oral exposure and oral half-life. Maintenance of high levels of anti-HBV cellular potency in conjunction with improvements in pharmacokinetic properties led to multi-log₁₀ reductions in serum HBV DNA following low, once-daily oral dosing for key analogs in a preclin. animal model of HBV replication. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anion Chelation via Double Chalcogen Bonding: The Case of a Bis-telluronium Dication and Its Application in Electrophilic Catalysis via Metal-Chloride Bond Activation was written by Zhou, Benyu;Gabbai, Francois P.. And the article was included in Journal of the American Chemical Society in 2021.COA of Formula: C19H15Cl This article mentions the following:

Telluronium cations have long been known to engage their counteranions via secondary interactions. Yet, this property has rarely been exploited for anion binding. Motivated by such an application, we have now synthesized a bis-telluronium dication ([3]²⁺) that was obtained as a tetrafluoroborate salt by reaction of 2,7-di-tert-butyl-9,9-dimethylxanthene-4,5-diboronic acid with phenoxatellurine difluoride and BF₃路OEt₂. As confirmed by the formation of Te-(渭-BF₄)-Te bridges in the structure of [3][BF₄]₂, [3]²⁺ functions as a bidentate Lewis acid toward anions. [3][BF₄]₂ has also been converted into the more exposed [3][BArF₂₄]₂ ([BArF₂₄]^– = [B(3,5-(CF₃)₂C₆H₃)₄]^–). The latter, which readily ionizes Ph₃CCl, displays a chloride anion binding constant that exceeds that of a monofunctional model compound by almost 4 orders of magnitude. The unique properties of this new bis-telluronium dication are further highlighted by its ability to activate Ph₃PAuCl and cis-(Ph₃P)₂PtCl₂, leading to catalytic systems highly active in the cycloisomerization of propargylamide or enyne substrates. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A highly stereoselective and recyclable microgel-supported bifunctional sulfonamide organocatalyst for asymmetric alcoholysis of meso-cyclic anhydrides: a thermo-responsive “organic nanoreactor” was written by Xiong, Fei;Ma, Chao;Zhu, Yi-Ren;Sun, Chen;Chen, Lu;Zhang, Yan-Jun;Zhu, Yuan-Jie;Wang, Zhong-Hua. And the article was included in New Journal of Chemistry in 2022.Category: chlorides-buliding-blocks This article mentions the following:

A novel thermosensitive bifunctional sulfonamide microgel catalyst was synthesized by immobilization on a highly cross-linked three-dimensional network structure through covalent interactions. The microgel-supported organocatalyst was successfully applied to catalyze the asym. alcoholysis reaction in high yields and good stereoselectivity (up to 90% ee). Furthermore, the polymeric catalysts could be recovered easily and reused multiple times (5 runs) without apparent loss of catalytic activity and enantioselectivity. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Category: chlorides-buliding-blocks).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borole/Borapyramidane Relationship was written by Sun, Qiu;Daniliuc, Constantin G.;Yu, Xiaoye;Mueck-Lichtenfeld, Christian;Kehr, Gerald;Erker, Gerhard. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 76-83-5 This article mentions the following:

Boroles and borapyramidanes are classical and nonclassical constitutional isomers, resp. It is here shown that they can indeed be interconverted. Treatment of the bis(alkynyl)B(C₆F₅) SMe₂ adduct 3路SMe₂ with HB(C₆F₅)₂ gave borole 1路SMe₂, featuring trimethylsilyl substituents in both 伪 positions to B, by a 1,1-hydroboration/alkenylboration sequence. Photolysis of the classical borole adduct 1路SMe₂ resulted in rearrangement to its nonclassical structural isomer, borapyramidane 2, in high yield, which exhibits a vicinal pair of trimethylsilyl substituents at the square pyramidane base. Neutral borapyramidane 2 is a rare example of an isoster of the (CH)₅⁺ pyramidane cation. Thermolysis of borapyramidane 2 in the presence of SMe₂ at 60掳 re-formed borole 1路SMe₂, which converted at 100掳 to 2,3-bis-silyl-substituted borole isomer 8路SMe₂. Its photolysis also gave borapyramidane 2. Prolonged photolysis of 2 at elevated temperatures converted this to borapyramidane isomer 10 containing a pair of trimethylsilyl groups in 1,3-position at its square C₄-pyramidal base. The borole and borapyramidane isomers were characterized by x-ray diffraction, and the system was analyzed by d. functional theory (DFT) calculations In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Study on d⁰ Metal-Catalyzed Alkyl-Alkyl Cross-Coupling Enabled by a Redox-Active Ligand was written by Belli, Roman G.;Tafuri, Victoria C.;Joannou, Matthew V.;Roberts, Courtney C.. And the article was included in ACS Catalysis in 2022.SDS of cas: 76-83-5 This article mentions the following:

Herein, a redox-active ligand-enabled alkyl-alkyl cross-coupling using a d⁰ metal was described. This tris(amido) ScIII complex as well as the oxidized variant was thoroughly characterized (NMR, X-ray, EPR, CV, UV-vis, DFT). Insight into the likely radical nature of the mechanism is disclosed. Addnl., a substrate scope that includes functional groups incompatible with late-transition-metal catalysis and both coupling partners bearing 尾-hydrogens was reported. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks was written by Slor, Gadi;Olea, Alis R.;Pujals, Silvia;Tigrine, Ali;De La Rosa, Victor R.;Hoogenboom, Richard;Albertazzi, Lorenzo;Amir, Roey J.. And the article was included in Biomacromolecules in 2021.Formula: C19H15Cl This article mentions the following:

Enzymically degradable polymeric micelles have great potential as drug delivery systems, allowing the selective release of their active cargo at the site of disease. Furthermore, enzymic degradation of the polymeric nanocarriers facilitates clearance of the delivery system after it has completed its task. While extensive research is dedicated toward the design and study of the enzymically degradable hydrophobic block, there is limited understanding on how the hydrophilic shell of the micelle can affect the properties of such enzymically degradable micelles. In this work, we report a systematic head-to-head comparison of well-defined polymeric micelles with different polymeric shells and two types of enzymically degradable hydrophobic cores. To carry out this direct comparison, we developed a highly modular approach for preparing clickable, spectrally active enzyme-responsive dendrons with adjustable degree of hydrophobicity. The dendrons were linked with three different widely used hydrophilic polymers-poly(ethylene glycol), poly(2-ethyl-2-oxazoline), and poly(acrylic acid) using the CuAAC click reaction. The high modularity and mol. precision of the synthetic methodol. enabled us to easily prepare well-defined amphiphiles that differ either in their hydrophilic block composition or in their hydrophobic dendron. The micelles of the different amphiphiles were thoroughly characterized and their sizes, critical micelle concentrations, drug loading, stability, and cell internalization were compared. We found that the micelle diameter was almost solely dependent on the hydrophobicity of the dendritic hydrophobic block, whereas the enzymic degradation rate was strongly dependent on the composition of both blocks. Drug encapsulation capacity was very sensitive to the type of the hydrophilic block, indicating that, in addition to the hydrophobic core, the micellar shell also has a significant role in drug encapsulation. Incubation of the spectrally active micelles in the presence of cells showed that the hydrophilic shell significantly affects the micellar stability, localization, cell internalization kinetics, and the cargo release mechanism. Overall, the high mol. precision and the ability of these amphiphiles to report their disassembly, even in complex biol. media, allowed us to directly compare the different types of micelles, providing striking insights into how the composition of the micelle shells and cores can affect their properties and potential to serve as nanocarriers. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A versatile living polymerization method for aromatic amides was written by Pal, Subhajit;Nguyen, Dinh Phuong Trinh;Molliet, Angelique;Alizadeh, Mahshid;Crochet, Aurelien;Ortuso, Roberto D.;Petri-Fink, Alke;Kilbinger, Andreas F. M.. And the article was included in Nature Chemistry in 2021.Computed Properties of C19H15Cl This article mentions the following:

Polycondensation polymers typically follow step-growth kinetics assuming all functional groups are equally likely to react with one another. If the reaction rates with the chain end can be selectively accelerated, living polymers can be obtained. Here we report on two chlorophosphonium iodide reagents that have been synthesized from triphenylphosphine and tri(o-methoxyphenyl)phosphine. The former activates aromatic carboxylic acids as acid chlorides in the presence of secondary aromatic amines and the latter even in the presence of primary aromatic amines. These reagents allow p-aminobenzoic acid derivatives to form solution-stable activated monomers that polymerize in a living fashion in the presence of amine initiators. Other aryl amino acids and even dimers of aryl amino acids can be polymerized in a living fashion when slowly added to the phosphonium salt in the presence of an amine initiator. Diblock copolymers and triblock terpolymers of aryl amino acids can be prepared even in the presence of electrophilic functional groups. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Computed Properties of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Installation of synergistic binding sites onto porous organic polymers for efficient removal of perfluorooctanoic acid was written by Liu, Xiongli;Zhu, Changjia;Yin, Jun;Li, Jixin;Zhang, Zhiyuan;Li, Jinli;Shui, Feng;You, Zifeng;Shi, Zhan;Li, Baiyan;Bu, Xian-He;Nafady, Ayman;Ma, Shengqian. And the article was included in Nature Communications in 2022.Product Details of 76-83-5 This article mentions the following:

Herein, we report a strategy to construct highly efficient perfluorooctanoic acid (PFOA) adsorbents by installing synergistic electrostatic/hydrophobic sites onto porous organic polymers (POPs). The constructed model material of PAF-1-NDMB (NDMB = N,N-dimethyl-butylamine) demonstrates an exceptionally high PFOA uptake capacity over 2000 mg g^-1, which is 14.8 times enhancement compared with its parent material of PAF-1. And it is 32.0 and 24.1 times higher than benchmark materials of DFB-CDP (尾-cyclodextrin (尾-CD)-based polymer network) and activated carbon under the same conditions. Furthermore, PAF-1-NDMB exhibits the highest k₂ value of 24,000 g mg^-1 h^-1 among all reported PFOA sorbents. And it can remove 99.99% PFOA from 1000 ppb to <70 ppt within 2 min, which is lower than the advisory level of Environmental Protection Agency of United States. This work thus not only provides a generic approach for constructing PFOA adsorbents, but also develops POPs as a platform for PFOA capture. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A versatile living polymerization method for aromatic amides was written by Pal, Subhajit;Nguyen, Dinh Phuong Trinh;Molliet, Angelique;Alizadeh, Mahshid;Crochet, Aurelien;Ortuso, Roberto D.;Petri-Fink, Alke;Kilbinger, Andreas F. M.. And the article was included in Nature Chemistry in 2021.Computed Properties of C19H15Cl This article mentions the following:

Polycondensation polymers typically follow step-growth kinetics assuming all functional groups are equally likely to react with one another. If the reaction rates with the chain end can be selectively accelerated, living polymers can be obtained. Here we report on two chlorophosphonium iodide reagents that have been synthesized from triphenylphosphine and tri(o-methoxyphenyl)phosphine. The former activates aromatic carboxylic acids as acid chlorides in the presence of secondary aromatic amines and the latter even in the presence of primary aromatic amines. These reagents allow p-aminobenzoic acid derivatives to form solution-stable activated monomers that polymerize in a living fashion in the presence of amine initiators. Other aryl amino acids and even dimers of aryl amino acids can be polymerized in a living fashion when slowly added to the phosphonium salt in the presence of an amine initiator. Diblock copolymers and triblock terpolymers of aryl amino acids can be prepared even in the presence of electrophilic functional groups. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Computed Properties of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Installation of synergistic binding sites onto porous organic polymers for efficient removal of perfluorooctanoic acid was written by Liu, Xiongli;Zhu, Changjia;Yin, Jun;Li, Jixin;Zhang, Zhiyuan;Li, Jinli;Shui, Feng;You, Zifeng;Shi, Zhan;Li, Baiyan;Bu, Xian-He;Nafady, Ayman;Ma, Shengqian. And the article was included in Nature Communications in 2022.Product Details of 76-83-5 This article mentions the following:

Herein, we report a strategy to construct highly efficient perfluorooctanoic acid (PFOA) adsorbents by installing synergistic electrostatic/hydrophobic sites onto porous organic polymers (POPs). The constructed model material of PAF-1-NDMB (NDMB = N,N-dimethyl-butylamine) demonstrates an exceptionally high PFOA uptake capacity over 2000 mg g^-1, which is 14.8 times enhancement compared with its parent material of PAF-1. And it is 32.0 and 24.1 times higher than benchmark materials of DFB-CDP (β-cyclodextrin (β-CD)-based polymer network) and activated carbon under the same conditions. Furthermore, PAF-1-NDMB exhibits the highest k₂ value of 24,000 g mg^-1 h^-1 among all reported PFOA sorbents. And it can remove 99.99% PFOA from 1000 ppb to <70 ppt within 2 min, which is lower than the advisory level of Environmental Protection Agency of United States. This work thus not only provides a generic approach for constructing PFOA adsorbents, but also develops POPs as a platform for PFOA capture. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics