Category: 76-83-5

Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents was written by Blindheim, Fredrik Heen;Olsen, Cecilie Elisabeth;Krogh Soegaard, Caroline;Otterlei, Marit;Sundby, Eirik;Hoff, Baard Helge. And the article was included in European Journal of Organic Chemistry in 2021.Quality Control of (Chloromethanetriyl)tribenzene This article mentions the following:

Imidazopyridinones I (R = H, OMe) and 7-azaoxindole II are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chem. Various synthetic methods and routes have been evaluated to identify safe and robust chem. to advanced imidazopyridinone I building blocks and inhibitor structures. Preparation of the 7-azaoxindoles II was challenged by instability of the core scaffold. Key to the successful isolation of the target structure was development of a mild Suzuki cross-coupling in non-aqueous media. The imidazopyridinones I were potent inhibitors of the E. coli thymidylate monophosphate kinase, while the 7-azaoxindole II showed low activity. The compounds were inactive in cell-based studies, indicating poor cell wall penetration. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Quality Control of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyl transferase was written by Wang, You;Xu, Feng;Nichols, Connie B.;Shi, Yuqian;Hellinga, Homme W.;Alspaugh, J. Andrew;Distefano, Mark D.;Beese, Lorena S.. And the article was included in Journal of Medicinal Chemistry in 2022.Related Products of 76-83-5 This article mentions the following:

Compounds that prevent farnesylation of Cryptoccoccus neoformans Ras protein by inhibiting protein farnesyl transferase with 3-4 nanomolar affinities was developed . Farnesylation directs Ras to the cell membrane and was required for infectivity of this lethal pathogenic fungus. Our high-affinity compounds inhibit fungal growth with 3-6 micromolar min. inhibitory concentrations (MICs), 4- to 8-fold better than Fluconazole, an antifungal commonly used in the clinic. Compounds bound with distinct inhibition mechanisms at two alternative, partially overlapping binding sites, accessed via different inhibitor conformations. Antifungal potency depends critically on the selected inhibition mechanism because this determines the efficacy of an inhibitor at low in vivo levels of enzyme and farnesyl substrate was showed. How chem. modifications of the antifungals encode desired inhibitor conformation and concomitant inhibitory mechanism was elucidated. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclic Trinuclear Copper(I) Complex Exhibiting Aggregation-Induced Emission: A Novel Fluorescent Probe for the Selective Detection of Gold(III) Ions was written by Li, Haozhen;Luo, Jie;Zhang, Zhi-Yin;Wei, Rong-Jia;Xie, Mo;Huang, Yong-Liang;Ning, Guo-Hong;Li, Dan. And the article was included in Inorganic Chemistry in 2022.Application of 76-83-5 This article mentions the following:

Coordination complexes with aggregation-induced-emission (AIE) behavior has drawn much attention because of their promising applications. Conventionally, the AIE-active metal-organic complexes are prepared from an AIE-active organic ligand, and the construction of such coordination complexes from aggregation-caused-quenching (ACQ) ligands is still challenging. Herein, we have synthesized two new cyclic trinuclear complexes (CTCs), namely, 1 and 2, from copper(I) and silver(I) and a ACQ ligand [4-(3,5-dimethyl-1H-pyrazol-4-yl)benzaldehyde, HL]. (1) Exhibited AIE behavior, and the emission intensity is enhanced ~20 times when it aggregates, which can be attributed to its tight packing and multiple intermol. hydrogen bonds that restrained the intramol. rotation, as confirmed by single-crystal X-ray diffraction anal. On the other hand, (2) displayed ACQ effects, and the emission intensity is decreased ~5 times when it aggregates. This ACQ behavior of 2 is related to its loose packing and free rotation of the ligand in crystals, resulting in nonradiative decay and fluorescence quenching. Interestingly, the CTCs 1 and 2 both exhibited a good affinity to gold(III) ions, allowing selective detection and sensing of gold ions. More importantly, the 2 shows a good limit of detection (3.28μmol/L) and an ultrafast responsive time (~2 s). Our studies pave a new route to designing novel AIE-active coordination complexes and further exploring the functionality of CTCs. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of the precursors of iminosugars with 7-membered ring was written by Osuch-Kwiatkowska, Anna;Jarosz, Slawomir. And the article was included in Carbohydrate Research in 2022.Safety of (Chloromethanetriyl)tribenzene This article mentions the following:

D-Glucose was converted into the orthogonally protected open-chain derivative having different blocks at both terminal positions: C1 and C6. Selective deprotection of the C1-position opened a route to intermediate with the D-gluco-configuration, while deprotection at the C6-position gave the L-gulo isomer. In both derivatives, the oxime functionality was installed at the proper terminal position, which produced the corresponding precursors of a family of 7-membered ring iminosugars. One of these oximes was converted into the direct precursor 6,1-bromonitrile I. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Safety of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct and Divergent Solid-Phase Synthesis of Azobenzene and Spiropyran Derivatives was written by Kollarigowda, Ravichandran H.;Braun, Paul V.. And the article was included in Journal of Organic Chemistry in 2021.Related Products of 76-83-5 This article mentions the following:

Here a solid-phase approach to synthesize azobenzenes I [Ar = 4-NH₂C₆H₄, 2,6-di-PhC₆H₃, 1-naphthyl, etc.] and spiropyran derivatives e.g., II was reported. The divergent synthesis process required no purification steps to obtain the desired product with 28-55% yield, depending on the specific compound For the spiropyran compounds, solid-phase resin cleavage was performed under mild condition to minimize spiropyran ring opening. The solid-phase method enabled synthesis of a library of azobenzene and spiropyran derivatives without the need of developing purification strategies for each derivative In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications was written by Huang, Jing-Ju;Lin, Chia-Hsuan;Tanaka, Yukiko;Yamamoto, Aki;Luo, Shyh-Chyang;Tanaka, Masaru. And the article was included in Advanced Materials Interfaces.SDS of cas: 76-83-5 This article mentions the following:

Poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have demonstrated potential in the development of bioelectrodes because of their superior conductivity However, developing reliable implanted bioelectrodes requires improvements in biocompatibility and the prevention of nonspecific adhesion. In this study, a six ethylene glycol (EG)-functionalized EDOTs with three different EG lengths (tri-EG, tetra-EG, and hexa-EG) and two types of end groups, hydroxyl (-OH) and methoxy (-OCH₃) is synthesized and systematically investigated. By coating them on gold electrodes using electropolymerization, the surface and electrochem. properties of these functionalized PEDOT-coated electrodes are investigated. Although PEDOT with -OH groups on the surface is more hydrophilic, those with -OCH₃ groups on the surface exhibit higher electrochem. activity and lower impedance. The increase in EG units and -OCH₃ groups on the surface effectively reduces the adhesion between the PEDOT and at. force microscopy tips. PEDOT with longer EG lengths and -OCH₃ groups exhibits relatively few adhered platelets, and the results of the anal. of hydrated states through differential scanning calorimetry are consistent with those of the platelet adhesion test. This study suggests that a tetra(EG)-functionalized PEDOT with -OCH₃ groups on the surface is a promising coating for implanted bioelectrode applications. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Air-stable nickel(II) borohydrides as prohydrides: Reactions with halocarbons and aerial carbon dioxide was written by Mani, Kalaikodikumaran;Pal, Parameswar;Anandababu, Karunanithi;Raje, Sakthi;Angamuthu, Raja. And the article was included in Inorganica Chimica Acta in 2021.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

Non-noble metal hydrides are highly attractive reagents owing to their involvement in the reactions of environmental and industrial interest. However, they are often cumbersome to isolate as a shelf-stable reagent. Herein, the authors have described the synthesis of non-noble metal hydrides by simple manual grinding of Ni(II)-chelates and NaBH₄ in open air at room temperature without using organic solvents. Two Ni(II) complexes of tetradentate N4 ligands, (L^NHCy = N,N’-bis(pyrid-2-ylmethyl)cyclohexanediamine) [(L^NHCy)Ni(MeCN)(H₂O)](ClO₄)₂ and [(tren)Ni(MeCN)₂](BPh₄)₂, were synthesized and their solid-state structures were confirmed by single crystal x-ray diffraction studies. Both the Ni complexes were manually ground with Na borohydride in open air to produce corresponding Ni(II)-borohydrides that were characterized using FTIR spectroscopy and powder x-ray diffraction techniques. Further, the borohydrides (prohydrides) activate the C-X bond in benzyl bromide, CDCl₃, trityl chloride and iodobenzene to yield toluene, CHDCl₂, triphenylmethane and benzene; the borohydrides reacted with trityl cation and air in MeCN solution to yield triphenylmethane and carbonate. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis was written by Gross, Sebastian;Schnell, Bastien;Haack, Patrick A.;Auerbach, David;Mueller, Rolf. And the article was included in Nature Communications in 2021.Reference of 76-83-5 This article mentions the following:

Abstract: Cystobactamids are myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-neg. activity. They are formed by a non-ribosomal peptide synthetase (NRPS) and consist of tailored para-aminobenzoic acids, connected by a unique α-methoxy-L-isoasparagine or a β-methoxy-L-asparagine linker moiety. We describe the heterologous expression of the cystobactamid biosynthetic gene cluster (BGC) in Myxococcus xanthus. Targeted gene deletions produce several unnatural cystobactamids. Using in vitro experiments, we reconstitute the key biosynthetic steps of linker formation and shuttling via CysB to the NRPS. The biosynthetic logic involves a previously uncharacterized bifunctional domain found in the stand-alone NRPS module CysH, albicidin biosynthesis and numerous BGCs of unknown natural products. This domain performs either an aminomutase (AM) or an amide dehydratase (DH) type of reaction, depending on the activity of CysJ which hydroxylates CysH-bound L-asparagine. Furthermore, CysQ O-methylates hydroxyl-L-(iso)asparagine only in the presence of the AMDH domain. Taken together, these findings provide direct evidence for unique steps in cystobactamid biosynthesis. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Reference of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New phorbol ester derivatives as potent anti-HIV agents was written by Li, Qi-Run;Cheng, Yung-Yi;Zhao, Lei;Huang, Xiao-Lei;Jiang, Xiao-Gang;Cui, Ya-Dong;Morris-Natschke, Susan L.;Goto, Masuo;Chen, Chin-Ho;Lee, Kuo-Hsiung;Chen, Dao-Feng;Zhang, Jian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

Tigliane esters show many biol. activities, including anti-HIV-1 activity. Our aim in this study was to establish structure-anti-HIV activity relationships for four series of tigliane-type diterpenoids. We synthesized and evaluated 29 new phorbol ester derivatives for anti-HIV activity and for cytotoxicity against human tumor cell lines. Among them, three derivatives, two phorbol-13-monoesters (5d and 5e) and a phorbol-12,13-diester (6a), showed significant anti-HIV activity. We found that better anti-HIV activity was often associated with a shorter acyl ester at C-13. Particularly, compounds with a Ph ring in the ester side chain exhibited excellent anti-HIV activity and had good safety indexes. Due to its significant anti-HIV potency with a high selectivity index, phorbol-12,13-dicinnamoate (6a) was chosen as the potential candidate for further preclin. trials. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new 1,4- and 1,5-disubstituted N-ethyl acetate and N-α-butyro-γ-lactone alkylimidazole derivatives as N-acylhomoserine lactone analogs was written by Qiang, Zhang;Li, Si-Zhe;Queneau, Yves;Soulere, Laurent. And the article was included in Journal of Heterocyclic Chemistry in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

New alkylimidazoles functionalized with a homoserine lactone or an alkyloxycarbonyl moiety was synthesized as N-acylhomoserine lactones (AHLs) analogs. The 1,4-disubstituted imidazole derivatives were prepared by alkylation of 4(5)-alkylimidazoles with α-bromo-γ-butyrolactone or Et α-bromoacetate. An alternative route was preferred for the synthesis of their 1,5-disubstituted counterparts based on the use of a N₁-protected alkylimidazole, its alkylation to an N₃-imidazolyl-α-acetate and deprotection to the desired 1,5-disubstituted esters and subsequent alkylation of the acetate moiety with cyclic ethylene sulfate followed by acid-catalyzed cyclization. The ability to modulate bacterial quorum sensing of all new compounds was compared to that of previously reported AHL analogs in which the amide bond is replaced by a heterocyclic group. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics