Category: 76-83-5

Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold was written by Jung, Eunkyung;Soto-Acosta, Ruben;Geraghty, Robert J.;Chen, Liqiang. And the article was included in Molecules in 2022.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

To search for Zika virus (ZIKV) antivirals, the previously reported 7H-pyrrolo[2,3-d]pyrimidines I (X = NH, O) have been explored by examining an alternative substitution pattern of their central scaffold, leading to compound I (X = O) with low micromolar antiviral activity. To circumvent the synthetic difficulties associated with compound I (X = O), a 1H-pyrazolo[3,4-d]pyrimidine II (R = H, 2-Me, 3-Cl, 4-Cl, etc.; R¹ = Ph, 4-nitrophenyl, 6-chloropyridin-3-yl, etc.) scaffold and structure-activity relationship studies pefromed on its peripheral rings A and B have been exploited . While ring B is less sensitive to structural modifications, an electron-withdrawing group at the para position of ring A is preferred for enhanced antiviral activity. Overall, we have not only discovered an alternative substitution pattern centered on a 1H-pyrazolo[3,4-d]pyrimidines IIscaffold but also generated anti-ZIKV compounds including 6 and 13, II (R = H, R¹ = 4-nitrophenyl; R = H, R¹ = 4-(trifluoromethyl)phenyl) which possess low micromolar antiviral activity and relatively low cytotoxicity. These compounds represent new chemotypes that will be further optimized in the continued efforts to discover anti-ZIKV agents. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Monosaccharide derivatives: synthesis, antimicrobial, pass, antiviral and molecular docking studies against SARS-CoV-2 Mpro inhibitors was written by Yasmin, Farhana;Amin, Mohammed R.;Hosen, Mohammed A.;Bulbul, Mohammed Z. H.;Dey, Sujan;Kawsar, Sarkar M. A.. And the article was included in Cellulose Chemistry and Technology in 2021.Related Products of 76-83-5 This article mentions the following:

Several carbohydrate-based drugs are currently being used to treat a number of diseases in humans worldwide. Thus, our research group has focused on the synthesis of new Me α-D-mannopyranoside (MDM) derivatives and their antimicrobial evaluation through computational studies. A series of MDM derivatives (2-6) were synthesized through facile regioselective acylation, using the direct method affording 6-O-(3-chlorobenzoyl) derivatives This isolated 6-O-derivative was further transformed to 2,3,4-tri-O-acyl derivatives, bearing a wide variety of functionalities in a single mol. framework. The structures of the newly designed mols. were elucidated with the aid of IR, ¹H NMR, mass spectroscopy, and elemental anal. The prediction of the activity spectra for the compounds (PASS) and their in vitro antimicrobial evaluation were performed, demonstrating them to be potential antimicrobial agents. The antimicrobial tests demonstrated that the compounds 3 and 5 were the most potent with the min. inhibitory concentration (MIC) values, ranging from 0.312 ± 0.01 to 1.25 ± 0.03 mg/mL, and min. bactericidal concentration (MBC) values, ranging from 0.625 ± 0.02 to 2.50 ± 0.05 mg/mL. A quantum chem. study was performed to calculate the thermodn., MO and electrostatic potential properties of the designed compounds Mol. docking simulation was carried out against SARS-CoV-2 Mpro protein 7BQY and 6Y84 to investigate their binding energy and binding tactics with the viral protein, and better binding affinity than that of the parent drug was observed Also, pharmacokinetic prediction revealed an improved drug-likeness profile for all MDM derivatives In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

NMR Analysis of a Series of 6,14-Ethenomorphinan Derivatives as PET Precursors and Reference Substances was written by Marton, Janos;Sipos, Attila;Henriksen, Gjermund;Cumming, Paul;Berenyi, Sandor;Schmitt, Bettina M.;Szabo, Zoltan. And the article was included in ChemistrySelect in 2021.Safety of (Chloromethanetriyl)tribenzene This article mentions the following:

The new semisynthetic oripavine derivative 3-O-trityl-6-O-desmethyl-dihydroetorphine was synthesized from the poppy alkaloid thebaine in a six-step procedure. This compound can be applied as precursor for the radiosynthesis of [6-O-methyl-¹¹C]-dihydroetorphine ([¹¹C]DHE) I. A detailed description of ¹H and ¹³C NMR data of reference standards and precursors for [6-O-methyl-¹¹C]- and [6-O-(2-[¹⁸F]fluoroethyl)]orvinols was presented. This includes the complete assignment for 19 oripavine derivatives, e.g., I examined in 1D and 2D NMR experiments The mol. basis for regioselectivity of fluoroalkylation of 3-O-trityl-6-O-desmethyl-phenethyl-orvinol (TDPEO) using computational methods was also investigated. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Safety of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peptidotriazolamers Inhibit Aβ(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model was written by Tonali, Nicolo;Hericks, Loreen;Schroeder, David C.;Kracker, Oliver;Krzemieniecki, Radoslaw;Kaffy, Julia;Le Joncour, Vadim;Laakkonen, Pirjo;Marion, Antoine;Ongeri, Sandrine;Dodero, Veronica I.;Sewald, Norbert. And the article was included in ChemPlusChem in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in mol. weight between small-mol. drugs and protein-based drugs. Amyloid β (Aβ) aggregates play an important role in Alzheimer′s disease. We studied the impact of amide bond replacements by 1,4-disubstituted 1H-1,2,3-triazoles on the inhibitory activity of the aggregation “hot spots” K16LVFF20 and G39VVIA42 in Aβ(1-42). We found that peptidotriazolamers act as modulators of the Aβ(1-42) oligomerization. Some peptidotriazolamers are able to interfere with the formation of toxic early Aβ oligomers, depending on the position of the triazoles, which is also supported by computational studies. Preliminary in vitro results demonstrate that a highly active peptidotriazolamer is also able to cross the blood-brain-barrier. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics