Category: 76052-76-1

Lumma, William C. Jr.; Hartman, Richard D.; Saari, Walfred S.; Engelhardt, Edward L.; Lotti, Victor J.; Stone, Clement A. published an article on January 31 ,1981. The article was titled 《Piperazinylquinoxalines with central serotoninmimetic activity》, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 2-Chloro-5-methoxyquinoxaline The information in the text is summarized as follows:

The piperazinylquinoxalines I (R = H, Ac, Me; R1 = H, OH (and the related ketone), CO2H; R2, R3 = H, Cl, NH2, CF3, SPh, OMe, F, etc.; m, n = 0, 1) were prepared by various methods. I were tested for selectivity in regards to serotonin reuptake blocking and serotoninmimetic activity. In general, introduction of a 6-substituent into I enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted I and I (R1 = OH) had primary serotoninmimetic activity. In addition to this study using 2-Chloro-5-methoxyquinoxaline, there are many other studies that have used 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1Quality Control of 2-Chloro-5-methoxyquinoxaline) was used in this study.

2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Quality Control of 2-Chloro-5-methoxyquinoxaline Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C9H7ClN2OOn May 31, 2010, Mohajeri, Afshan; Shahamirian, Mozhgan published an article in Journal of Physical Organic Chemistry. The article was 《Substituent effect on local aromaticity in mono and di-substituted heterocyclic analogs of naphthalene》. The article mentions the following:

A quant. study on local aromaticity has been performed on a series of mono- and di-substituted biheterocycles (quinoline, isoquinoline, quinoxaline, quinazoline). Three electronically based indexes (PDI, ATI, and FLU) have been employed to investigate the substituent effect on the π-electron delocalization in both heterocycle and benzenoid rings. Three typical substituents (Cl, OCH3, and CN) with different inductive and resonance power have been selected. Generally, substituent causes a reduction in aromaticity irresp. of whether it is electron attracting or electron donating. It is shown that the maximum aromaticity exhibits a similar trend of Cl > CN > OCH3 for all the studied rings. Moreover, it is found that the substituent situation with respect to the heteroatom has a significant influence on the aromaticity. It results from our study that in di-substituted derivatives, irresp. of whether the two substituents form a meta or para isomer, they preferably choose the position which leads to the maximum aromaticity character. Copyright © 2009 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1COA of Formula: C9H7ClN2O)

2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C9H7ClN2O However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lumma, William C. Jr.; Hartman, Richard D.; Saari, Walfred S.; Engelhardt, Edward L.; Lotti, Victor J.; Stone, Clement A. published an article on January 31 ,1981. The article was titled 《Piperazinylquinoxalines with central serotoninmimetic activity》, and you may find the article in Journal of Medicinal Chemistry.Quality Control of 2-Chloro-5-methoxyquinoxaline The information in the text is summarized as follows:

The piperazinylquinoxalines I (R = H, Ac, Me; R1 = H, OH (and the related ketone), CO2H; R2, R3 = H, Cl, NH2, CF3, SPh, OMe, F, etc.; m, n = 0, 1) were prepared by various methods. I were tested for selectivity in regards to serotonin reuptake blocking and serotoninmimetic activity. In general, introduction of a 6-substituent into I enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted I and I (R1 = OH) had primary serotoninmimetic activity. In addition to this study using 2-Chloro-5-methoxyquinoxaline, there are many other studies that have used 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1Quality Control of 2-Chloro-5-methoxyquinoxaline) was used in this study.

2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Quality Control of 2-Chloro-5-methoxyquinoxaline Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C9H7ClN2OOn May 31, 2010, Mohajeri, Afshan; Shahamirian, Mozhgan published an article in Journal of Physical Organic Chemistry. The article was 《Substituent effect on local aromaticity in mono and di-substituted heterocyclic analogs of naphthalene》. The article mentions the following:

A quant. study on local aromaticity has been performed on a series of mono- and di-substituted biheterocycles (quinoline, isoquinoline, quinoxaline, quinazoline). Three electronically based indexes (PDI, ATI, and FLU) have been employed to investigate the substituent effect on the π-electron delocalization in both heterocycle and benzenoid rings. Three typical substituents (Cl, OCH3, and CN) with different inductive and resonance power have been selected. Generally, substituent causes a reduction in aromaticity irresp. of whether it is electron attracting or electron donating. It is shown that the maximum aromaticity exhibits a similar trend of Cl > CN > OCH3 for all the studied rings. Moreover, it is found that the substituent situation with respect to the heteroatom has a significant influence on the aromaticity. It results from our study that in di-substituted derivatives, irresp. of whether the two substituents form a meta or para isomer, they preferably choose the position which leads to the maximum aromaticity character. Copyright © 2009 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1COA of Formula: C9H7ClN2O)

2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C9H7ClN2O However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C9H7ClN2OOn September 15, 2003 ,《Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Myers, Michael R.; He, Wei; Hanney, Barbara; Setzer, Natalie; Maguire, Martin P.; Zulli, Allison; Bilder, Glenda; Galzcinski, Helen; Amin, Dilip; Needle, Saul; Spada, Alfred P.. The article contains the following contents:

Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents led to significant improvements in the pharmacokinetic profile of these analogs. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1Computed Properties of C9H7ClN2O)

2-Chloro-5-methoxyquinoxaline(cas: 76052-76-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H7ClN2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics