Category: 768-35-4

《Dearomative 1,4-difunctionalization of naphthalenes via palladium-catalyzed tandem Heck/Suzuki coupling reaction》 was published in Nature Communications in 2020. These research results belong to Zhou, Bo; Wang, Hongliang; Cao, Zhong-Yan; Zhu, Jia-Wen; Liang, Ren-Xiao; Hong, Xin; Jia, Yi-Xia. Application of 768-35-4 The article mentions the following:

Reported herein is an application of naphthalenes I [R = 2-bromophenyl, N-(2-bromophenyl)-N-methylcarbamoyl, 2-bromo-5-(methoxycarbonyl)phenoxymethyl, N-(3-bromopyridin-2-yl)-N-methylcarbamoyl, etc.; R1 = H, OMe; R2 = H, Br; R3 = H, OMe; R4 = H; R3R4 = -CH=CH-CH=CH-] as a masked conjugated diene in a palladium-catalyzed dearomative 1,4-diarylation or 1,4-vinylarylation reaction via tandem Heck/Suzuki sequence. Three types of 1,4-dihydronaphthalene-based spirocyclic compounds II [X = N, CH; R5 = Me, Bn; R6 = H, 4-F, 5-OMe, 6-CF3, etc.; R7 = Ph, 4-ethenylphenyl, 3,4-difluorophenyl, etc.; R8 = H, Ph]/III [R9 = H, 4-Me, 4-OMe, 4-F, 5-Me, 5-F; R10 = Et, n-Pr, Ph, etc.; R11 = Ph, 3-methylphenyl, naphthalen-2-yl] are achieved in excellent regio- and diastereoselectivities. Key to this transformation is the inhibition of a few competitive side reactions, including intramol. naphthalenyl C-H arylation, intermol. Suzuki cross-coupling, dearomative 1,2-difunctionalization, and dearomative reductive-Heck reaction. D. functional theory (DFT) calculations imply that the facile exergonic dearomative insertion of a naphthalene double bond disrupts the sequence of direct Suzuki coupling, leading to the tandem Heck/Suzuki coupling reaction. The observed regioselectivity towards 1,4-difunctionalization is due to the steric repulsions between the introduced aryl group and the spiro-scaffold in 1,2-difunctionalization. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Application of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Cell Chemical Biology included an article by Ohki, Yu; Sakurai, Hidetaka; Hoshino, Madoka; Terashima, Hideki; Shimizu, Hiroki; Ishikawa, Tomio; Ogiyama, Tomoko; Muramatsu, Yasunori; Nakanishi, Toshiyuki; Miyazaki, Shojiro; Tsuruoka, Hiroyuki; Kobayashi, Hideki; Kubota, Kazuishi. Recommanded Product: 768-35-4. The article was titled 《Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology》. The information in the text is summarized as follows:

Mol. target identification of small mols., so-called target deconvolution, is a major obstacle to phenotype-based drug discovery. Here, we developed an approach called perturbation-based proteomic correlation profiling (PPCP) utilizing the correlation between protein quantity and binding activity of compounds under cellular perturbation by gene silencing and successfully identified lanosterol synthase as a mol. target of TGF-β pathway inhibitor. This PPCP concept was extended to the use of a cell line panel and provides a new option for target deconvolution. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Liang, Junqing; Han, Jie; Wu, Jingjing; Wu, Pingjie; Hu, Jian; Hu, Feng; Wu, Fanhong. Application In Synthesis of (3-Fluorophenyl)boronic acid. The article was titled 《Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones》. The information in the text is summarized as follows:

A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents α-bromo-α-fluoroketones by using a trifluoroacetate release protocol. Mechanistic investigation indicated that a monofluoroalkyl radical is involved in the catalytic circle. Moreover, an important medical intermediate of flindokalner was synthesized via a nickel-catalyzed coupling reaction of α-bromo-α-fluoro-2-indolone and boronic ester. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《δ C-H (hetero)arylation via Cu-catalyzed radical relay》 were Zhang, Zuxiao; Stateman, Leah M.; Nagib, David A.. And the article was published in Chemical Science in 2019. HPLC of Formula: 768-35-4 The author mentioned the following in the article:

A Cu-catalyzed strategy was developed that harnesses a radical relay mechanism to intercept a distal C-centered radical for C-C bond formation. This approach enabled selective δ C-H (hetero)arylation of sulfonamides via intramol. hydrogen atom transfer (HAT) by an N-centered radical. The radical relay was both initiated and terminated by a Cu catalyst, which enabled incorporation of arenes and heteroarenes by cross-coupling with boronic acids. The broad scope and utility of this catalytic method for δ C-H arylation was showed, along with mechanistic probes for selectivity of the HAT mechanism. A catalytic, asym. variant was also presented, as well as a method for accessing 1,1-diaryl-pyrrolidines via iterative δ C-H functionalizations. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jian-Ping; Li, Yi; Liu, Chao; Wang, Tianyi; Chung, Lung Wa; Xu, Ming-Hua published their research in Organic Letters in 2021. The article was titled 《Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic β2/γ2/δ2-Amino Acid Derivatives》.Recommanded Product: 768-35-4 The article contains the following contents:

A highly enantioselective rhodium-catalyzed intermol. hydroarylation of α-aminoalkyl acrylates using water as a direct proton source was realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of α-aryl-methyl-substituted β2- γ2- δ2-amino esters I [Ar = Ph, 2-ClC6H4, 2-naphthyl, etc.] with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions. By utilizing this method, a series of structurally interesting benzo-fused heterocyclic mols. and corresponding β2- γ2- and δ2-amino esters II [R = 2-ylisoindoline-1,3-dione, NHBoc; Ar = Ph, 3-ClC6H4, 4-F3CC6H4, etc.; n = 2,3] were facilely constructed. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: (3-Fluorophenyl)boronic acidIn 2019 ,《New approach to unsymmetrical 1,3-diazatriphenylenes through intramolecular oxidative cyclodehydrogenation》 appeared in Tetrahedron. The author of the article were Verbitskiy, Egor V.; Eltsov, Oleg S.; Zhilina, Ekaterina F.; Pakhomov, Ilya M.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.. The article conveys some information:

An efficient synthetic route towards previously inaccessible dibenzo[f,h]quinazolines and [1]benzothieno[3,2-f]benzo[h]quinazolines through FeCl3-mediated intramol. oxidative cyclodehydrogenation of readily available 5-([1,1′-biphenyl]-2-yl)pyrimidines and 5-(2-phenylbenzo[b]thiophen-3-yl)pyrimidines was described. MO calculations (DFT), as well as redox and photophys. measurements for all new compounds was performed. The data showed that the reported polycyclic systems have a potential to use in organic electronic applications. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Palladium immobilized on functionalized hypercrosslinked polymers: a highly active and recyclable catalyst for Suzuki-Miyaura coupling reactions in water》 were Liu, Xi; Xu, Wei; Xiang, Dexuan; Zhang, Zaixing; Chen, Dizhao; Hu, Yangjian; Li, Yuanxiang; Ouyang, Yuejun; Lin, Hongwei. And the article was published in New Journal of Chemistry in 2019. HPLC of Formula: 768-35-4 The author mentioned the following in the article:

Heterogeneous catalysts have shown advantages such as high stability, good recyclability and easy separation from reactants over homogeneous catalysts in recent years. In this paper, three pyridine-functionalized N-heterocyclic carbene-palladium complexes (HCP-Pd) were successfully synthesized via a simple external crosslinking reaction. In each catalyst (i.e., complex), palladium (Pd) was immobilized on the hypercrosslinked polymer (HCP) via formation of a six-membered ring by Pd2+ and the bidentate ligands of NHC and pyridine. The structure and composition of HCP-Pd were characterized by SEM, TEM, N2 sorption, FT-IR, TGA and XPS. The catalytic performances of these catalysts in a Suzuki-Miyaura coupling reaction were also studied. The results prove that HCP-Pd is a very effective heterogeneous catalyst for the Suzuki-Miyaura coupling reaction of various aryl halides with aryl boronic acid in an aqueous medium under mild conditions. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Rhodium(III) Catalyzed Regioselective and Stereospecific Allylic Arylation in Water by β-Fluorine Elimination of the Allylic Fluoride: Toward the Synthesis of Z-Alkenyl-Unsaturated Amides》 was published in Organic Letters in 2020. These research results belong to Casalta, Clement; Bouzbouz, Samir. Name: (3-Fluorophenyl)boronic acid The article mentions the following:

A direct coupling of arylboronic acids with allylic fluorides was carried out in water without additives using a rhodium(III) catalyst (Cp*RhCl2)2. The transformation proceeded with excellent γ-selectivity to afford major allyl-aryl coupling products (Z) γ-substituted α,β-unsaturated amides. The reactions of α-chiral allylic fluorides took place with excellent α-to-γ chirality transfer to give allylated arenes with a stereogenic center at the benzylic and allylic position. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Shen, Dadong; Liu, Hanyu; Qian, Feng; Wang, Pu published an article in Bioorganic Chemistry. The title of the article was 《Design, synthesis and evaluation of novel thienopyridazine derivatives as Chk1/2 inhibitors》.Related Products of 768-35-4 The author mentioned the following in the article:

In order to search for novel checkpoint kinase 1/2 (Chk1) inhibitors, a series of new compounds I.HCl [X = H2C, HN; R = 4-MeO, 4-Cl, 3-Cl, etc.; R1 = pyrrolidin-3-ylmethyl, 3-piperidylmethyl, 3-piperidyl, (3S)-3-piperidyl, 4-piperidyl; R2 = H, Me, Et, etc.] and II [X = H2C, HN; R = 4-MeO, 4-Cl, 3-Cl, etc.; R2 = H, Me, Et, etc.; R3 = (1-tert-butoxycarbonylpyrrolidin-3-yl)methyl, (1-tert-butoxycarbonyl-3-piperidyl)methyl, 1-tert-butoxycarbonylazetidin-3-yl, etc.] incorporating thienopyridazine core were designed and synthesized. Bioevaluation showed that compounds I.HCl [X = HN, R = 3-Cl, R1 = 3-piperidylmethyl, R2 = Et; X = HN, R = 2-Cl, R1 = pyrrolidin-3-ylmethyl, R2 = Et; X = H2C, R = 4-Cl, R1 = 3-piperidyl, R2 = Me; X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] exhibited relatively good inhibitory activity. Notably, compound I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] displayed high selectivity against a panel of kinases and inhibited Chk1/2 signaling pathway stimulated by DNA damage drugs in cellular level. Mol. docking of I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] to the ATP-binding site of Chk1 kinase domain indicated the existence of polar interactions between I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] and the ATP-ribose-binding residues of Chk1. In mouse HT-29 xenografts, a synergistic effect was observed Co-treatment by CPT-11 and I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] significantly diminished the tumor volume, indicating the great potential of I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] as a candidate of Chk1/2 inhibitor. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C6H6BFO2In 2021 ,《Access and modulation of substituted 1-methyl-1,6-dihydropyrazolo[3,4-c]pyrazoles》 appeared in RSC Advances. The author of the article were Ostache, Nicu-Cosmin; Hiebel, Marie-Aude; Finaru, Adriana-Luminita; Allouchi, Hassan; Guillaumet, Gerald; Suzenet, Franck. The article conveys some information:

A convenient design of new pyrazolo[3,4-c]pyrazoles I (R = C6H5, 4-OCH3-C6H4, 4-CF3-C6H4; R1 = H, Br, Ph, 3-thiophene, 4-pyridine, styril, etc.) with a high therapeutic impact has been described. The effective chosen strategy consists of hydrazine condensations and C-N Ullmann-type cross-coupling reactions with microwave activation. Moreover, chemoselective bromination of the newly formed bipyrazoles followed by Suzuki-Miyaura cross-coupling reactions allowed the synthesis of a variety of modulated heterobicycles. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics