Category: 768-35-4

The author of 《Pd-Catalyzed Enantioselective Ring Opening/Cross-Coupling and Cyclopropanation of Cyclobutanones》 were Cao, Jian; Chen, Ling; Sun, Feng-Na; Sun, Yu-Li; Jiang, Ke-Zhi; Yang, Ke-Fang; Xu, Zheng; Xu, Li-Wen. And the article was published in Angewandte Chemie, International Edition in 2019. Computed Properties of C6H6BFO2 The author mentioned the following in the article:

A palladium-catalyzed enantioselective sequential ring-opening/cross-coupling of cyclobutanones is disclosed that provides chiral indanones bearing C3-quaternary stereocenters. The reaction process involves palladium-catalyzed nucleophilic addition of cyclobutanones and aryl halides, enantioselective β-carbon elimination, and intermol. trapping of a transient σ-alkylpalladium complex with boronic acids. Alternatively, an intramol. cyclopropanation is realized through C-H bond functionalization in the absence of external coupling reagents, affording chiral cyclopropane-fused-indanones in good yields and enantioselectivity.(3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents》 were Zhao, Liyu; Tian, Linfeng; Sun, Nannan; Sun, Yin; Chen, Yixuan; Wang, Xinran; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng. And the article was published in European Journal of Medicinal Chemistry in 2019. Related Products of 768-35-4 The author mentioned the following in the article:

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alc. derivatives were designed and synthesized. 3-F substituted compounds 14i(A), 14n(B), 14s(C) and 14v(D) exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03-0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1-2 μg/mL. Notably, Compounds A, B, C and D also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of D stemmed from inhibition of C. albicans CYP51. Compounds B and D were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.(3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Medicinal Chemistry included an article by Zhao, Liyu; Sun, Nannan; Tian, Linfeng; Sun, Yin; Chen, Yixuan; Wang, Xinran; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng. Name: (3-Fluorophenyl)boronic acid. The article was titled 《Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives》. The information in the text is summarized as follows:

A series of β-azole-phenylacetone derivatives I (R1 = H, 2-F, 3-F, etc. ; R2 = 2-CH3, 4-F, 2-Cl, etc.; R3 = 3-Cl, 4-F, 4-CH3, etc.) with novel structures were designed and synthesized to combat the increasing incidence of susceptible fungal infections and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against five susceptible strains and five fluconazole-resistant strains and most of the compounds exhibited excellent antifungal activities with MIC values in the range of 0.03-1 μg/mL. Compounds I (R1 = 3-F, R2 = R3 = H), I (R1 = R2 = H; R3 = 2-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) exhibited moderate antifungal activities against fluconazole-resistant strains 17# and CaR with MIC values in the range of 1-8 μg/mL. Compounds I (R1 = 2-F; R2 = R3 = H), I (R1 = R2 = H; R3 = 2-F) and I (R1 = R3 = 2-F; R2 = H) displayed moderate to good antifungal activity against fluconazole-resistant strains 632, 901 and 904 with MIC values in the range of 0.125-4 μg/mL. Notably, I (R1 = R2 = H; R3 = 2-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) exhibited antifungal activity against five susceptible strains and five fluconazole-resistant strains. Preliminary mechanistic studies showed that the potent antifungal activity of compound I (R1 = 2-F; R2 = H; R3 = 4-CH3) stemmed from inhibition of C. albicans CYP51. Compounds I (R1 = R2 = H; R3 = 2-F), I (R1 = 3-F; R2 = H; R3 = 4-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) were nearly nontoxic to mammalian A549 cells. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Zhang, Wen; Wu, Lianqian; Chen, Pinhong; Liu, Guosheng. Quality Control of (3-Fluorophenyl)boronic acid. The article was titled 《Enantioselective Arylation of Benzylic C-H Bonds by Copper-Catalyzed Radical Relay》. The information in the text is summarized as follows:

A novel enantioselective copper-catalyzed arylation of benzylic C-H bonds, using alkylarenes as a limiting reagent, has been developed. A chiral bisoxazoline ligand bearing an acetate ester moiety plays a key role in both the reactivity and enantioselectivity of the reaction. The reaction provides efficient access to various chiral 1,1-diarylalkanes in good yields with good to excellent enantioselectivities, and displays excellent functional-group tolerance. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Runlai; Huang, Mingxin; Zhang, Shuai; Li, Long; Li, Mi; Sun, Jun; Wu, Lan; Guan, Qi; Zhang, Weige published an article in 2021. The article was titled 《Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of (3-Fluorophenyl)boronic acid The information in the text is summarized as follows:

A series of new 6- substututed phenyl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles I [R = H, 4-F, 2-F-4-Me, etc.] as tubulin polymerization inhibitors targeting the colchicine-binding site were designed to restrict bioactive configuration of (Z,E)-vinylogous CA-4. All of the target compounds I were synthesized and then evaluated for their in-vitro antiproliferative activities. Among them, compound I [R = 3-HO-4-MeO] exhibited the most potent activities against three cancer cell lines with IC50 values in the range of 0.037-0.20μM. Further mechanism studies revealed that compound I [R = 3-HO-4-MeO] inhibited tubulin polymerization, disrupted cell microtubule networks, arrested the cell cycle at G2/M phase, induced apoptosis and hindered cancer cell migration. Moreover, compound I [R = 3-HO-4-MeO] displayed significant in-vivo antitumor efficacy in 4T1-xenograft mice model with tumor growth inhibition rate of 52% at the dose of 2.5 mg/kg. Colchicine competition assay and the docking model of compound I [R = 3-HO-4-MeO] in complex with tubulin showed that compound I [R = 3-HO-4-MeO] acted at the colchicine-binding site. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jin; Zhang, Pei; Shao, Lei; Wang, Ruihong; Ma, Yangmin; Szostak, Michal published an article in 2022. The article was titled 《Mechanochemical Solvent-Free Suzuki-Miyaura Cross-Coupling of Amides via Highly Chemoselective N-C Cleavage》, and you may find the article in Angewandte Chemie, International Edition.Product Details of 768-35-4 The information in the text is summarized as follows:

The first mechanochem. strategy for highly chemoselective, solvent-free palladium-catalyzed cross-coupling of amides by N-C bond activation was reported. The method was conducted in the absence of external heating, for short reaction time and shows excellent chemoselectivity for σ N-C bond activation. The reaction showed excellent functional group tolerance and could be applied to late-stage functionalization of complex APIs and sequential orthogonal cross-couplings exploiting double solventless solid-state methods. The results extend mechanochem. reaction environments to advance the chem. repertoire of N-C bond interconversions to solid-state environmentally friendly mechanochem. methods. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sanchez-Velasco, Oriel A.; Saavedra-Olavarria, Jorge; Araya-Santelices, Daniel A. A.; Hermosilla-Ibanez, Patricio; Cassels, Bruce K.; Perez, Edwin G. published their research in Journal of Natural Products in 2021. The article was titled 《Synthesis of N-Arylcytisine Derivatives Using the Copper-Catalyzed Chan-Lam Coupling》.Computed Properties of C6H6BFO2 The article contains the following contents:

N-Arylcytisine derivatives are quite rare. We report here a practical methodol. to obtain these compounds Using the copper-catalyzed Chan-Lam coupling, we synthesized new N-arylcytisine derivatives at room temperature, in air and using inexpensive phenylboronic acids. Cytisine and 3,5-dihalocytisines can act as substrates, and among the products, the p-Br-derivative was used as a substrate to obtain biaryl derivatives under Pd-coupling conditions; ester-derivative was converted into its acid and amide derivatives using classical carbodiimide conditions. This shows that the Chan-Lam cross-coupling reaction can be included as a versatile synthetic tool in the derivatization of natural products.(3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Hybrid Palladium Catalyst Assembled from Chiral Phosphoric Acid and Thioamide for Enantioselective β-C(sp3)-H Arylation》 was written by Jiang, Hua-Jie; Zhong, Xiu-Mei; Liu, Zi-Ye; Geng, Rui-Long; Li, Yang-Yang; Wu, Yun-Dong; Zhang, Xinhao; Gong, Liu-Zhu. SDS of cas: 768-35-4 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A hybrid palladium catalyst assembled from a chiral phosphoric acid (CPA) and thioamide enables a highly efficient and enantioselective β-C(sp3)-H functionalization of thioamides (up to 99% yield, 97% ee; e.g., N,N-diisopropyl isobutyric thioamide + PhB(OH)2 → I (91% isolated, 96% ee)). A kinetic resolution of unsym. thioamides by intermol. C(sp3)-H arylation can be achieved with high s-factors. Mechanistic investigations have revealed that stereocontrol is achieved by embedding the substrate in a robust chiral cavity defined by the bulky CPA and a neutral thioamide ligand. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4SDS of cas: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.SDS of cas: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

You, Zhensheng; Higashida, Kosuke; Iwai, Tomohiro; Sawamura, Masaya published an article in 2021. The article was titled 《Phosphinylation of Non-activated Aryl Fluorides through Nucleophilic Aromatic Substitution at the Boundary of Concerted and Stepwise Mechanisms》, and you may find the article in Angewandte Chemie, International Edition.Recommanded Product: (3-Fluorophenyl)boronic acid The information in the text is summarized as follows:

Non-activated aryl fluorides reacted with potassium diorganophosphinites through a nucleophilic aromatic substitution (SNAr) reaction. Remarkably, both electron-neutral and electron-rich aryl fluorides participated in the reaction with substantially stabilized anionic P nucleophiles to form the corresponding tertiary phosphine oxides. Quantum chem. calculations suggested a nucleophile-dependent mechanism that involves both concerted and stepwise SNAr reaction pathways. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: (3-Fluorophenyl)boronic acid) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Redox-Neutral Nickel(II) Catalysis: Hydroarylation of Unactivated Alkenes with Arylboronic Acids》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Wang, Dao-Ming; Feng, Wang; Wu, Yichen; Liu, Tao; Wang, Peng. HPLC of Formula: 768-35-4 The article mentions the following:

Reported here is the discovery of a redox-neutral NiII/NiII catalytic cycle which is capable of the linear-selective hydroarylation of unactivated alkenes with arylboronic acids for the first time. This novel catalytic cycle, enabled by the use of an electron-rich diimine ligand, features broad substrate scope, and excellent functional-group and heterocycle compatibility under mild reaction conditions in the absence of addnl. oxidants and reductants. Mechanistic investigations using kinetic anal. and deuterium-labeling experiments revealed the protonation to be the rate-determining step in this redox-neutral catalysis, and the reversible chain-walking nature of the newly developed diimine-Ni catalyst. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics