Category: 777-44-6

Ring-Expansion Reactions of Epoxy Amides and Enamides: Functionalized Azetidines, Dihydrofurans, Diazocanes, or Dioxa-3-azabicyclonon-4-enes? was written by Suraj;Swamy, K. C. Kumara. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 777-44-6 This article mentions the following:

Functionalized azetidines I [R¹ = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R² = Ph, 2-BrC₆H₄, 2-IC₆H₄, etc.], 2,3-dihydrofurans II [R³ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.] or the unorthodox dioxa-3-azabicyclonone-4-ene motifs III [R⁴ = Ph, 4-BrC₆H₄, 2-naphthyl, etc.; R⁵ = Ph, 4-MeC₆H₄, 2-BrC₆H₄, etc.] were the products from transition metal-free reaction between N-oxiranylmethyl benzenesulfonamide and 尾-chloro-cinnamaldehyde, depending on whether one uses either NaI/K₂CO₃ or LiBr/K₂CO₃. These ring expansion reactions involved enamide (X-ray evidence) derived from N-oxiranylmethyl benzenesulfonamide and 尾-chloro-cinnamaldehyde as an intermediate. The N-oxiranylmethyl benzenesulfonamide itself upon heating gave readily separable and crystalline isomeric diazocanes that could be characterized by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Product Details of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Activity of Novel Fungicides Containing a 1,2,3,4-Tetrahydroquinoline Scaffold and Acting as Laccase Inhibitors was written by Zhang, Xiaoming;Xu, Huan;Su, Huifei;Yang, Xinling;Sun, Tengda;Lu, Xingxing;Shi, Fasheng;Duan, Hongxia;Liu, Xili;Ling, Yun. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Formula: C7H4ClF3O2S This article mentions the following:

In this work, PMDD-5Y was selected as a lead compound, designed and used to synthesize a series of novel sulfonyl hydrazide derivatives containing the natural product scaffold 1,2,3,4-tetrahydroquinoline I (R¹ = H, 6-Me, 2-Me; R² = 2-chlorophenyl, 4-nitrophenyl, Bu, etc.; X = O, S) . The new compounds I had antifungal activities against several fungi, especially Valsa mali and Sclerotinia sclerotiorum. One compound I (R¹ = H, R¹ = 4-chlorophenyl, X = S) displayed very good in vitro activity against S. sclerotiorum and V. mali, with EC50 values of 3.32 and 2.78渭g/mL, resp. The results of an enzyme activity assay showed that compound I (R¹ = H, R¹ = 4-tert-butylphenyl, X = S) had the best inhibitory activity against laccase, with an EC50 value of 14.85渭g/mL. This was more active than the lead compound PMDD-5Y and the pos. control cysteine. Using a mol. docking method, the binding mode of the title compounds I with laccase was studied . The structural features of these new laccase inhibitors as fungicides will advance research and impact the field of discovering more potent fungicides to control diseases in agriculture. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety was written by Xie, Dandan;Hu, Xin;Ren, Xiaoli;Yang, Zaiping. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Related Products of 777-44-6 This article mentions the following:

In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100渭g/mL and 50渭g/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of indole-picolinamide hybrid molecules as carbonic anhydrase-II inhibitors: Biological and computational studies was written by Zaib, Sumera;Khan, Imtiaz;Anbar, Hanan S.;Zaraei, Seyed-Omar;Sbenati, Rawan M.;Maryam, Hafiza Taha;Shah, Hamid Saeed;El-Gamal, Mohammed I.. And the article was included in Journal of Molecular Structure in 2022.Category: chlorides-buliding-blocks This article mentions the following:

The present study reported the successful synthesis and evaluation of a series of indole-picolinamide hybrids I, II [Ar = Ph, 3-CF₃C₆H₄, 3,4-di-ClC₆H₃], III, IV and V as potent inhibitors of bovine carbonic anhydrase II, a promising therapeutic target for the treatment of neurol. disorders, osteoporosis, glaucoma, cancer and obesity. Various multistep synthetic approaches were utilized to access the desired structures having exclusive sites for chem. modifications and diverse spots for biol. interactions between the ligand and enzyme. Compound I was observed as a potent inhibitor of the bovine CA-II with an IC₅₀ value of 0.0440 卤 0.009渭M. The inhibition potency was about 22-fold higher than the standard drug acetazolamide (IC₅₀ = 0.9618 卤 0.180渭M). Several relevant structure-activity relationships were deduced that enlighten the crucial role of substituents as well as the key pharmacophores involved in the inhibition process. Mol. docking tools reinforced the in vitro assay results. The most active compound I was also investigated for anticancer potential using sulforhodamine B assay and results showed two-fold efficacy against HeLa cells when compared to standard drug cisplatin (IC₅₀ = 8.045 卤 3.791渭g/mL and 4.128 卤 1.473渭g/mL, resp.). These findings were also confirmed by flow cytometry and comet tests. Moreover, fluorescence microscopy with DAPI staining revealed apoptosis as a mechanism of cancer cell death. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones on melanin synthesis in murine B16 cells was written by Nie, Li Fei;Bozorov, Khurshed;Niu, Chao;Huang, Guozheng;Aisa, Haji Akber. And the article was included in Research on Chemical Intermediates in 2017.COA of Formula: C7H4ClF3O2S This article mentions the following:

A series of novel sulfonamide derivatives containing tricyclic thieno[2,3-d]pyrimidinones I (R = Ph, 4-FC₆H₄, 2-F₃CC₆H₄, 3,5-Cl₂C₆H₃, etc.) was synthesized and evaluated for melanin synthesis in murine B16 cells. All new compounds were characterized by ¹H NMR, ¹³C NMR, IR and HRMS. Among them, 6 compounds demonstrated excellent activity than pos. control (8-methoxylpsoralen, 8-MOP) with more than 1.5-fold potency. Compound I (R = 3,5-Cl₂C₆H₃) was the most potent one (658.3 卤 8.7%), exhibiting 5.0-fold stronger activity than 8-MOP (130.9 卤 8.6%). The compound I (R = 3,5-F₂C₆H₃) increased melanin synthesis in murine B16 cells with a 4.35-fold potency as compared to 8-MOP. These compounds may serve as lead compounds for further drug discoveries for the treatment of vitiligo. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6COA of Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives was written by Bagul, Suresh D.;Rajput, Jamatsing D.;Tadavi, Samina K.;Bendre, Ratnamala S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Abstract: Sulfonamides have enormous importance in biol. sciences. In the present investigation, the fundamental energetic group, hydrazide-based sulfonamide, has been incorporated into a naturally occurring phenolic monoterpenoid, carvacrol (5-isopropyl-2-methylphenol) moiety, with the aim of combining the active groups to generate more potent antimicrobial and anti-oxidant agents. Series of hydrazide-based sulfonamide derivatives (IV a-g) have been synthesized and characterized by modern sophisticated techniques such as ¹H NMR, ¹³C NMR and LC-MS. The newly synthesized derivatives were screened for their antimicrobial activities against three fungal (Aspergillus niger, A. flavus and A. fumigatus) and three bacterial (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) species, of which compounds IVc and IVd were found to have good antifungal activity and compounds IVd and IVg exhibited decent antibacterial activities. Antioxidant activity was performed by DPPH radical scavenging assay. Compound IVd has been found to be more active in comparison to standard ascorbic acid and compounds IVa, IVb, and IVc demonstrated excellent antioxidant activity. Graphical Abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

9-Sulfonyl-9(H)-Purine Derivatives Inhibit HCV Replication Via their Degradation Species was written by Hu, Rong;Wang, Wan-Li;Xiao, Kun-Jie;Wang, Ning-Yu. And the article was included in Pharmaceutical Chemistry Journal in 2021.Category: chlorides-buliding-blocks This article mentions the following:

Cell-based screening of a privileged small mol. library led to the discovery of 9-sulfonyl-9(H)-purine as new scaffold for hepatitis C virus (HCV) inhibitors. Structure-activity relationship study with respect to the 2-, 6- and 9-positions in the purine core resulted in the identification of several active compounds with moderate potency against the HCV genotype 1b. Subsequent stability studies demonstrated that HCV inhibitors of this type were unstable in Dulbecco’s modified eagle medium (DMEM) and plasma, as well as glutathione-containing water, and their instability was closely related to their HCV inhibitory activity. A preliminary study of the mechanism of action showed that the sulfonamide bond at the 9-position of purine would be the primary degradation site and the resulting sulfonylation degradation species would mediate the anti-HCV activity of 9-sulfonyl-9(H)-purines. Results of this study demonstrated that 9-sulfonyl-9(H)-purine is an unstable scaffold for HCV inhibitors and further detailed anal. of the degradation species is needed to determine the main active components and direct target for this type of mols. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid was written by Zhang, Wen-Ming;Yao, Yang;Yang, Teng;Wang, Xue-Ying;Zhu, Zhen-Yun;Xu, Wen-Tao;Lin, Hai-Xia;Gao, Zhao-Bing;Zhou, Hu;Yang, Cai-Guang;Cui, Yong-Mei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Computed Properties of C7H4ClF3O2S This article mentions the following:

A series of N-sulfonaminoethyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having chloro, bromo, trifluoromethyl Ph moiety exhibited potent in vitro antistaphylococcal activity. The meta-CF3 Ph derivative T23 showed the highest activity with MIC of 0.390.78 渭g/mL against S. aureus Newman, while several analogs showed similar potent antibacterial activity with MIC values between 0.78 and 1.56 渭g/mL against fve multidrug-resistant S. aureus. The stability of T35 in plasma of SD rat and the cellular cytotoxicity were also evaluated. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Computed Properties of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents was written by Gadekar, Pradip K.;Roychowdhury, Abhijit;Kharkar, Prashant S.;Khedkar, Vijay M.;Arkile, Manisha;Manek, Hardik;Sarkar, Dhiman;Sharma, Rajiv;Vijayakumar, V.;Sarveswari, S.. And the article was included in European Journal of Medicinal Chemistry in 2016.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

The design, synthesis and antimicrobial evaluation of a novel series of azaspiro analogs I [R = acetyl, 4-(trifluoromethyl)benzoyl, nicotinoyl, etc.] of linezolid were described. Linezolid comprises of a morpholine ring which was known for its metabolism-related liabilities. Therefore, the key modification made in the linezolid structure was the replacement of morpholine moiety with its bioisostere, 2-oxa-6-azaspiro[3.3]heptane. Furthermore, the replacement of N-acetyl terminal of linezolid with various aromatic or aliphatic functionalities was carried out. The title compounds were evaluated against a panel of Gram-pos. and Gram-neg. bacteria and Mycobacterium tuberculosis. Subsequent structure-activity relationship (SAR) studies identified several compounds with mixed antibacterial and antitubercular profiles. Compound I [R = isoxazole-5-carbonyl] (IC₅₀ 0.72, 0.51, 0.88, 0.49 渭g/mL for Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillussubtilis, resp.) exhibited similar antibacterial profile as linezolid. The N-acetyl derivative I [R = acetyl] was similar to linezolid in antitubercular profile. The use of azaspiro substructure in the medicinal chem. of antibacterial and antitubercular agents was demonstrated. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains was written by Araujo-Neto, Jose B. de;Silva, Maria M. C. da;Oliveira-Tintino, Cicera D. de M.;Begnini, Ieda M.;Rebelo, Ricardo A.;Silva, Luiz E. da;Mireski, Sandro L.;Nasato, Michele C.;Krautler, Maria I. L.;Ribeiro-Filho, Jaime;Siyadatpanah, Abolghasem;Wilairatana, Polrat;Coutinho, Henrique D. M.;Tintino, Saulo R.. And the article was included in Molecules in 2021.Category: chlorides-buliding-blocks This article mentions the following:

The purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the min. inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H)-one and 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide. The antibiotic-modulating activity was analyzed using subinhibitory concentrations (MIC/8) of these compounds in combination with norfloxacin, ofloxacin, and lomefloxacin. Multi-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were used in both tests. Although the compounds had no direct antibacterial activity (MIC 鈮?1.024渭g/mL), they decreased the MIC of these fluoroquinolones, indicating synergism was obtained from the association of the compounds These results suggested the existence of a structure-activity relationship in this group of compounds with regard to the modulation of antibiotic activity. Therefore, concluded that 1,8-naphthyridine derivatives potentiate the activity of fluoroquinolone antibiotics against multi-resistant bacterial strains, and thereby interesting candidates for the development of drugs against bacterial infections caused by multidrug resistant strains. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics