78068-85-6 Archives - Chlorides-buliding-blocks

Application of 78068-85-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-fluorobenzotrifluoride, other downstream synthetic routes, hurry up and to see.

Related Products of 78068-85-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78068-85-6, name is 3-Chloro-4-fluorobenzotrifluoride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 1-benzofuran-6-ol (418.5 mg, 3.1 mmol) in 6 ml of DMF was added 3-Chloro-4-fluorobenzotrifluoride (681.4 mg, 3.4 mmol) and cesium carbonate (1.5 g, 4.7 mmol). The reaction mixture was heated at 80 C. for 2 hours. After cooling to room temperature, it was diluted with ethyl acetate, washed with water (2×) and brine, dried over magnesium sulfate, filtered and concentrated. The crude product was purified on a silica gel column, eluting with ethyl acetate (0-30%) in hexane. The final product was collected as colorless oil. 1H NMR (CDCl3, delta ppm): 6.8 (s, 1H), 7.0 (two d, 2H), 7.2 (s, 1H), 7.4 (d, 1H), 7.6 (d, 1H), 7.7 (s, 1H), 7.8 (s, 1H).

Reference:
Patent; Ge, Min; He, Jiafang; Lau, Fiona Wai Yu; Liang, Gui-Bai; Lin, Songnian; Liu, Weiguo; Walsh, Shawn P.; Yang, Lihu; US2007/265332; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some tips on 78068-85-6

The synthetic route of 3-Chloro-4-fluorobenzotrifluoride has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 78068-85-6, name is 3-Chloro-4-fluorobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H3ClF4

To a suspension of 3,3′-dihydroxydiphenyl disulfide (1.01 g, 4.03 mmol) and Cs2CO3 (3.3 g, 10 mmol) in DMF (20 mL) was added 3-chloro-4-fluorobenzotrifluoride (2 g, 10 mmol). The reaction was heated at 100 C. overnight. The mixture was then cooled and partitioned between ether (200 mL) and water (200 mL). The aqueous layer was further extracted with ether (2¡Á100 mL). The organic layers were combined, washed with water (1¡Á100 mL), Brine (1¡Á100 mL), dried with anhydrous sodium sulfate, filtered and concentrated. The resulting oil was used in the next step directly.

The synthetic route of 3-Chloro-4-fluorobenzotrifluoride has been constantly updated, and we look forward to future research findings.

Simple exploration of 78068-85-6

The synthetic route of 78068-85-6 has been constantly updated, and we look forward to future research findings.

Reference of 78068-85-6, These common heterocyclic compound, 78068-85-6, name is 3-Chloro-4-fluorobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 6-hydroxyindan-1-one (1.48 g, 10 mmol) in 30 ml of DMF was added 3-chloro-4-fluorobenzotrifluoride (2.46 g, 12 mmol) and cesium carbonate (8.40 g, 25 mmol). The reaction mixture was heated at 80 C. for 12 h. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with water (2*) and brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel chromatography, eluding with ethyl acetate (2-40%) in hexane. The final productproduct was collected as brownish yellow oil.

The synthetic route of 78068-85-6 has been constantly updated, and we look forward to future research findings.