Category: 79349-53-4

Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochlorideOn October 31, 2012 ,《Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe》 appeared in Nature Chemistry. The author of the article were Xie, Hexin; Mire, Joseph; Kong, Ying; Chang, Mi Hee; Hassounah, Hany A.; Thornton, Chris N.; Sacchettini, James C.; Cirillo, Jeffrey D.; Rao, Jianghong. The article conveys some information:

Early diagnosis of tuberculosis can dramatically reduce both its transmission and the associated death rate. The extremely slow growth rate of the causative pathogen, Mycobacterium tuberculosis (Mtb), however, makes this challenging at the point of care, particularly in resource-limited settings. Here the authors report the use of BlaC (an enzyme naturally expressed/secreted by tubercle bacilli) as a marker and the design of BlaC-specific fluorogenic substrates as probes for Mtb detection. These probes showed an enhancement by 100-200 times in fluorescence emission on BlaC activation and a >1000-fold selectivity for BlaC over TEM-1 β-lactamase, an important factor in reducing false-pos. diagnoses. Insight into the BlaC specificity was revealed by successful co-crystallization of the probe/enzyme mutant complex. A refined green fluorescent probe (CDG-OMe) enabled the successful detection of live pathogen in less than ten minutes, even in unprocessed human sputum. This system offers the opportunity for the rapid, accurate detection of very low numbers of Mtb for the clin. diagnosis of tuberculosis in sputum and other specimens. In the part of experimental materials, we found many familiar compounds, such as (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Qing-fang published an article in Huaxue Shiji. The title of the article was 《Improvement and synthesis of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hdyrochloride》.Computed Properties of C21H20Cl2N2O3S The author mentioned the following in the article:

7-Amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hydrochloride was synthesized from diphenylmethyl 7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride by condensation, N-alkylation and hydrolysis in an overall yield of 77.8%. The purity of the title compound was over 98% by HPLC. This procedure was simple, mild and safe, suitable for scale-up production(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Computed Properties of C21H20Cl2N2O3S) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C21H20Cl2N2O3S Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Ultrasonic-assisted synthesis of two t-butoxycarbonylamino cephalosporin intermediates on SiO2》 were Xue, Feng; Wei, Yibin; Ju, Shengui; Xing, Weihong. And the article was published in Journal of Chemistry in 2016. Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The author mentioned the following in the article:

Herein, a facile and high efficient strategy for the synthesis of two forms of the 7β-t-butoxycarbonylamino- 3-chloromethyl-3-cephem-4-carboxylates I [R = 4-MeOC6H4CH2, HCCH(Ph)2] using ultrasonic irradiation was described. By SiO2 as weak Lewis acid catalyst, compound I were successfully synthesized through the efficient protection of the N-tbutoxycarbonyl (N-Boc) and the reactions occurred at low temperature requiring short reaction times and exhibiting excellent isolated yields (96% and 96.2%, resp.). The advantages of this reaction route included the usage of economical reagents and mild reaction conditions and high isolated yield make the two significant t-butoxycarbonylamino cephalosporin intermediates possible in large-scale production The results came from multiple reactions, including the reaction of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Katsura, Yousuke; Aratani, Matsuhiko published their research in Tetrahedron Letters on December 19 ,1994. The article was titled 《A convenient protective method for the 7-amino function on a cephem derivative in Wittig vinylation》.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The article contains the following contents:

A novel preparative pathway for diphenylmethyl 7β-amino-3-vinylceph-3-em-4-carboxylate from 3-chloromethyl derivative is described. As a convenient protecting group for the 7-amino function in a Wittig reaction, six membered azine derivatives, e.g., I, incorporating the 7-amino group were developed as a surrogate of conventional protecting groups. The experimental process involved the reaction of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Cephalosporin antibiotics. I. Synthesis and structure-activity relationships of 3-thiazoliomethyl derivatives》 was written by Nakayama, Eiji; Fujimoto, Koichi; Muramatsu, Shigeki; Miyauchi, Masao; Watanabe, Katsuhiko; Ide, Junya. Safety of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride And the article was included in Journal of Antibiotics on August 31 ,1991. The article conveys some information:

The synthesis and structure-activity relationships of the title compounds, e.g., I (R = H, Me, CH2CH2F; X = O, S) are described. Of all the thiazoliomethyl derivatives prepared the most potent bactericides were I. In addition to this study using (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride, there are many other studies that have used (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Safety of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochlorideOn September 30, 1995 ,《Studies on 3′-quaternary ammonium cephalosporins II. Synthesis and antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporin derivatives bearing various quaternary ammonium methyl groups at the 3 position》 was published in Journal of Antibiotics. The article was written by Ohki, Hidenori; Kawabata, Kohji; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo. The article contains the following contents:

Synthesis and antibacterial activity of quaternary ammonium cephalosporins is reported. Extremely potent broad-spectrum activity against both Gram-pos. bacteria, including S. aureus, and Gram-neg. bacteria, including P. aeruginosa, is exhibited by 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-amino-2-methylpyrazolio)-methyl-3-cephem-4-carboxylate.(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 79349-53-4On May 30, 1993, Okita, Takaaki; Imae, Kiyoto; Hasegawa, Toshifumi; Iimura, Seiji; Masuyoshi, Shinji; Kamachi, Hajime; Kamei, Hideo published an article in Journal of Antibiotics. The article was 《Synthesis and antibacterial activity of cephalosporins having a catechol in the C3 side chain》. The article mentions the following:

Cephalosporins I [R = H, Me, CMe2CO2H, R1 = (E)-CH:CHCH2O2CC6H3(OH)2-3,4, O2CC6H3(OH)2-3,4; R = Me, R1 = O2CCH2C6H3(OH)2-3,4] were prepared I [ R = CMe2CO2H, R1 = (E)-CH:CHCH2O2CC6H3(OH)2-3,4, O2CC6H3(OH)2-3,4] showed excellent activity against Gram-neg. bacteria including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. In the experiment, the researchers used many compounds, for example, (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4SDS of cas: 79349-53-4)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 79349-53-4 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds》 was written by Naito, Takayuki; Aburaki, Shimpei; Kamachi, Hajime; Narita, Yukio; Okumura, Jun; Kawaguchi, Hiroshi. Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride And the article was included in Journal of Antibiotics on August 31 ,1986. The article conveys some information:

Cephems, e.g., I (R = Me, Et, CHMe2, CH2CH:CH2, CH2CCH), were prepared and the structure-activity relationship of various substituents on the oxyimino moiety and on the quaternary ammonium moiety was determined I (R = Me) had broad antimicrobial activity against Gram-pos. and Gram-neg. bacteria, including Pseudomonas aeruginosa. The experimental part of the paper was very detailed, including the reaction process of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A Switch-On Fluorescence Assay for Bacterial β-Lactamases with Amyloid Fibrils as Fluorescence Enhancer and Visual Tool》 were Zou, Lan; Cheong, Wing-Lam; Chung, Wai-Hong; Leung, Yun-Chung; Wong, Kwok-Yin; Wong, Man-Kin; Chan, Pak-Ho. And the article was published in Chemistry – A European Journal in 2010. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Herein is described the development of a novel switch-on fluorescence assay for detecting β-lactamases. The fluorescence assay comprises two components: solid beads coated with a β-lactam antibiotic, which is linked to an environment-sensitive fluorophore (dansylaminothiophenol, DTA), and amyloid fibrils of hen lysozyme (acting as fluorescence enhancer and visual tool). In the presence of the clin. significant TEM-1 β-lactamase, the DTA-antibiotic complex on the solid beads is hydrolyzed, thus releasing the DTA dye into solution The DTA dye is only weakly fluorescent in solution but gives strong green fluorescence upon binding to lysozyme fibrils. These strongly fluorescent DTA-bound fibrils can be easily visualized by the naked eye upon illumination of the sample with a simple UV lamp. The fluorescence assay can detect TEM-1 at low concentration (0.01 nM). In contrast, no observable fluorescence appears when the fluorescence assay is performed on samples without the TEM-1 β-lactamase. In addition to this study using (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride, there are many other studies that have used (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Category: chlorides-buliding-blocks) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Category: chlorides-buliding-blocks Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamanaka, Hideaki; Chiba, Toshiyuki; Kawabata, Kohji; Takasugi, Hisashi; Masugi, Takashi; Takaya, Takao published their research in Journal of Antibiotics on December 31 ,1985. The article was titled 《Studies on β-lactam antibiotics. IX. Synthesis and biological activity of new orally active cephalosporin, cefixime (FK027)》.Recommanded Product: 79349-53-4 The article contains the following contents:

7β-[(Z)-2-(2-Amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-3- vinyl-3-cephem-4-carboxylic acid (I) was prepared from diphenylmethyl 7-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride (II), prepared from 7-aminocephalosporanic acid by two parallel routes differing primarily in the protection of the 7-amino group. II was alternatively prepared from deacetylcephalosporin C sodium salt with improved yields. Two pathways for the conversion of II to I are provided. I is orally active with a widely expanded antimicrobial activity and high stability to β-lactamases. In the experiment, the researchers used many compounds, for example, (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Recommanded Product: 79349-53-4)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 79349-53-4 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics