Discovery of 81067-38-1

The synthetic route of 81067-38-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 81067-38-1, A common heterocyclic compound, 81067-38-1, name is 1-Bromo-2,3,5-trichlorobenzene, molecular formula is C6H2BrCl3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2. 2,3,5-Trichlorobenzeneboronic Acid A solution of 2,3,5-trichlorobromobenzene (8.60 g, 0.033 mole) in dry ether (33 ml) and bromoethane (4.73 ml, 7.31 g, 0.067 mole) was added dropwise to a suspension of magnesium turnings (2.809, 0.12 mole) in dry ether (21.50 ml) at room temperature. The mixture was refluxed for 0.50 hr and cooled to room temperature. The mixture was then added dropwise under nitrogen to a solution of trimethylborate (5.16 ml, 5.16 g, 0.05 mole) in dry ether (8.60 ml) maintaining the temperature below -60 C. This was warmed to room temperature overnight, then cooled in an ice-bath and treated with 2M hydrochloric acid (10 ml). The ether layer was separated, washed with water (2*20 ml), dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated in vacuo. The residue was triturated with 40-60 C. petroleum ether, filtered and dried in vacuo. Yield 4.57 g (61%), M.p. 257-260 C.

The synthetic route of 81067-38-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Glaxo Wellcome, Inc.; US6255307; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics