Category: 81927-55-1

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 81927-55-1, Name is Benzyl 2,2,2-trichloroacetimidate, molecular formula is C9H8Cl3NO, belongs to chlorides-buliding-blocks compound, is a common compound. In a patnet, author is Meng, Xiaorong, once mentioned the new application about 81927-55-1, Category: chlorides-buliding-blocks.

A colour changeable optical sensing membrane was prepared for quantitative detection of Cd(II), Zn(II) and Cu (II) by using polyvinyl chloride membrane containing bis(2-ethylhexyl) phosphate for chemical absorption of chromogenic reagent 1-(2-pyridylazo)-2-naphthol. Under the optimum conditions, the three ions were measured by UV-visible spectrophotometer at lambda max = 547, 554 and 560 nm, respectively. The linear ranges of 8.90 x 10(-9)-8.90 x 10(-4) mol.L-1 [Cd(II)], 1.78 x 10(-9)-1.78 x 10(-4) mol.L-1 [Zn(II)] and 1.78 x 10(-7)-1.78 x 10(-3) mol.L-1 [Cu(II)] and detection limits of 3.89 x 10(-9), 3.42 x 10(-10) and 1.20 x 10(-7) mol.L-1 were obtained, respectively. The response time was between 7 and 15 min. For common anions and cations, the sensing membrane exhibited good selectivity. Selective determination of Cd(II), Zn(II) and Cu(II) was achieved by adding a suitable masking agent. The sensing membrane was regenerated by soaking in nitric acid for 1-3 min and maintained a stable response after three times of reuse. The sensing membrane was successfully used for the determination of Cd(II), Zn(II) and Cu(II) in real samples.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 81927-55-1. The above is the message from the blog manager. Category: chlorides-buliding-blocks.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application of 81927-55-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 81927-55-1, Name is Benzyl 2,2,2-trichloroacetimidate, SMILES is ClC(Cl)(Cl)C(=N)OCC1=CC=CC=C1, belongs to chlorides-buliding-blocks compound. In a article, author is Champaka, Gurudevaru, introduce new discover of the category.

Monomeric zinc ferrocene carboxylate [Zn(FcCOO)(3,5-dmp)(2)Cl] (1) has been synthesized from a reaction between the zinc chloride, sodium salt of ferrocene carboxylic acid (FcCOONa) and 3,5-dimethylpyrazole (3,5-dmp) at room temperature. Compound 1 was further characterized by elemental analysis, H-1 NMR, FT-IR, absorption, emission spectroscopic techniques, and molecular structure was confirmed by single-crystal X-ray diffraction studies. The molecular structure of compound 1 crystallized in triclinic system with P (1) over bar space group and the central Zn2+ ion is in a distorted tetrahedral geometry with -FeN2OCl coordination environment. Compound 1 was further stabilized with the aid of inter and intramolecular hydrogen bonding and pi-pi interaction between cyclopentadienyl ring of ferrocene and aromatic heterocyclic five membered 3,5-dimethylpyrazole. Compound 1 exhibits broad emission band, indicating ligandto-metal charger transfer (LMCT) or metal-to-ligand charger transfer (MLCT) nature. The electrochemical property of compound 1 revealed that one-electron anodic and cathodic peaks corresponding to the redox responsible of ferrocene/ferrocenium (FeII <-> Fe-III) moiety. Among the different strains of bacteria, the antibacterial activity of compound 1 showed comparatively a significant activity against gram negative bacterium Proteus vulgaris. (C) 2020 Elsevier B.V. All rights reserved.

Application of 81927-55-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 81927-55-1.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81927-55-1, Product Details of 81927-55-1

To a solution of (R)-Roche ester 25 (200 mg, 1.69 mmol, 1equiv) in CH2Cl2 (3 mL) was added at 0 oC benzyl trichloroacetimidate (640 mg, 2.54 mmol, 1.5 equiv). Asolution of CF3SO3H in CH2Cl2 (0.85 M, 100 muL, 0.09 mmol, 0.05 equiv) was added at 0 oC and the mixture wasstirred at room temperature for 44 h. After filtration, the filtrate was concentrated under reduced pressureand saturated aqueous NaHCO3 (15 mL) was added. The aqueous layer was extracted with EtOAc, thecombined organic layers were washed with brine, dried over MgSO4 and concentrated under reducedpressure. The crude mixture was purified by flash column chromatography (SiO2, petroleum ether/Et2O: 95/5)to afford the desired product 26 (262 mg, 74%) as a yellow oil. Rf (cyclohexane/EtOAc: 9/1, UV, KMnO4) 0.30;-8.0 (c 1.60, CHCl3); 1H NMR (CDCl3, 300 MHz) delta = 7.38 – 7.24 (m, 5H), 4.53 (s, 2H), 3.70 (s, 3H), 3.66 (dd,J 9.2, 7.3 Hz, 1H), 3.50 (dd, J 9.1, 5.9 Hz, 1H), 2.86 – 2.72 (m, 1H), 1.18 (d, J 7.1 Hz, 3H); 13C NMR (CDCl3, 75MHz) delta 175.4, 138.3, 128.5, 127.7 (2C), 73.2, 72.1, 51.8, 40.3, 14.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Echeverria, Pierre-Georges; Pons, Amandine; Prevost, Sebastien; Ferard, Charlene; Cornil, Johan; Guerinot, Amandine; Cossy, Janine; Phansavath, Phannarath; Ratovelomanana-Vidal, Virginie; Arkivoc; vol. 2019; 4; (2019); p. 44 – 68;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 81927-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81927-55-1 name is Benzyl 2,2,2-trichloroacetimidate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A stirred solution of (S)- methyl 3-hydroxy-2-methylpropanoate (9.60 g, 81.3 mmol) and benzyl 2,2,2- trichloroacetimidate (22.57 g, 89.4 mmol) in CH2Cl2 (14 mL) was cooled to 0 0C under N2. Triflic acid (0.1 mL) in CH2CI2 (1 mL) was added dropwise. After 10 minutes the reaction became a solid mass. After 1 hour, saturated aqueous NaHCO3 was added and the mixture extracted with Et2O. The organics were dried over MgSO4, filtered and concentrated on a rotary evaporator. Hexane was added and the resulting solids collected by vacuum filtration. The filtrate was concentrated on a rotary evaporator and purified using flash chromatography (5-10% EtOAc/hexane) to give 11.82 g (70%) of (S)-methyl 3-(benzyloxy)-2- methylpropanoate as a colorless oil. Rf= 0.20 (10% EtOAc/hexane). 1H NMR (300 MHz, DMSO-D6) delta ppm 1.08 (d, J=7.14 Hz, 3 H) 2.75 (ddd, J=14.01, 12.64, 7.14 Hz, 1 H) 3.44 – 3.59 (m, 2 H) 3.60 (s, 3 H) 4.46 (s, 2 H) 7.23 – 7.40 (m, 5 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl 2,2,2-trichloroacetimidate, and friends who are interested can also refer to it.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2007/84560; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 81927-55-1, A common heterocyclic compound, 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, molecular formula is C9H8Cl3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(R)-Methyl 3-hydroxybutanoate (2.0 g, 17.0 mmol, 1.0 equiv) was stirred in cyclohexane(113 mL) and CH2Cl2 (56 mL) and benzyl 2,2,2-trichloroacetimidate (8.56 g, 33.9 mmol, 2.0 equiv) followed byTsOHH2O (10 mL, 0.85 mmol, 0.1 equiv) were added and the mixturestirred at 25 C for 18 h. Reactionwas quenched with saturatedaqueous NaHCO3 (100 mL) and the solution extracted with CH2Cl2(3100 mL), dried (MgSO4), rotary evaporated, and chromatographed(1:9 EtOAc/hexanes) to afford benzyl-protected alcohol 68(2.66 g, 76%) as a clear oil, which was used without further purification.Methyl ester 68 was stirred in NaOH (1 M, 22.0 mL,22.1 mmol, 1.8 equiv) and THF (20 mL) for 72 h. The mixture wasacidified to pH 3 using 1 M HCl, extracted with CH2Cl2 (3200 mL),the organic extracts combined, washed with brine (150 mL), dried(MgSO4), and rotary evaporated to afford carboxylic acid 69 (1.94 g,83%) as a clear oil: Rf 0.4 (1:9 MeOH/CH2Cl2); [a]D25 0.83 (c 0.113,CHCl3); IR (neat) nmax 3029 (br), 1706, 1454, 1377, 1305, 1204, 1134,1075 cm1; 1H NMR (500 MHz, C6D6) d 7.25e7.24 (m, 2H), 7.17e7.14(m, 2H), 7.08e7.05 (m, 1H), 4.27 (q, J13.0 Hz, 2H), 3.80e3.74 (m,1H), 2.44 (dd, J15.0, 7.0 Hz, 1H), 2.13 (dd, J15.0, 5.0 Hz, 1H), 0.96(d, J6.0 Hz, 3H); 13C NMR (125 MHz, C6D6) d 177.3, 139.1, 128.2(2C), 128.0, 127.8 (2C), 71.7, 70.8, 41.8, 19.6; HRMS (CI) calcd forC11H18NO, requires 212.1287, found 212.1297 (D4.7 ppm); Anal.Calcd for C11H14O3: C, 68.02; H, 7.27. Found: C, 68.13; H, 7.14.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Anderson, Katie; Laclef, Sylvain; Barrett, Anthony G.M.; Tetrahedron; vol. 70; 35; (2015); p. 5569 – 5579;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 81927-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81927-55-1 name is Benzyl 2,2,2-trichloroacetimidate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of methyl (3R)-3-hydroxybutanoate (10 g) and benzyl 2,2,2-trichloroethanimidate (23.6 g) in CH2CI2 (300 mL) was added CF3SO3H (7.2 g) and the mixture was stirred at 25C for 12 h. The reaction mixture was concentrated under reduced pressure to remove CH2CI2. The residue was diluted with water (100 mL), extracted with four times with ethyl acetate (90 mL) and concentrated under reduced pressure. The residue was purified by column chromatography (5i02, petroleum ether / ethylacetate, 20:1 to 9:1) to give methyl (3R)-3-benzyloxybutanoate (10 g, 56.7%) as colorless oil. LCMS:209.1 (M÷Hi

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl 2,2,2-trichloroacetimidate, and friends who are interested can also refer to it.

Reference:
Patent; FLAGSHIP PIONEERING INNOVATIONS V, INC.; CASEY, John P.; BERRY, David; CASTRO, Alfredo; TAYLOR, Steven J.; MASSARI, Ferdinand E.; PROUSFOOT, John; BOGART, Elijah; BRIGGS, Timothy F.; (211 pag.)WO2018/226732; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, A new synthetic method of this compound is introduced below., Recommanded Product: Benzyl 2,2,2-trichloroacetimidate

[0484] To a solution of Scheme 5-8 compound SI (24 g, 0.136 mol) and benzyl 2,2,2- trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 ml.,) at room temperature was added trifJuoromethanesuifonic anhydride (cat. 1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight, and filtered. The filtrate was washed with sat. NaHCCb, brine, dried over anhydrous Nay.SO-i, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate 10. 1 ) to afford the title compound (35 g, 93.3% yield) as a yellow oil .

The synthetic route of 81927-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (325 pag.)WO2017/35405; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Benzyl 2,2,2-trichloroacetimidate

To a solution of Scheme 5-7 compound SI (24 g, 0. 136 mol) and benzyl 2,2,2- trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 niL) at room temperature was added triiluoromeihanesulfomc anhydride (cat. L2 mi..) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHC03 and brine, dried over anhydrous Na2Si, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (S2) (35 g, 93.3% yield) as a yellow oil.

The synthetic route of 81927-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (333 pag.)WO2017/35401; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 81927-55-1 as follows. Application In Synthesis of Benzyl 2,2,2-trichloroacetimidate

To a solution of scheme 58 compound Si (24 g, 0136 mol) and benzyl 2,2,2- thchioroaceiirnidate (5 1)3 g, 0204 inol) in cvchexanedichloromethane (600 inL120 ml..) at room temperature was added tritluorornethanesulfonic anhydride (cat. 1 .2 mE) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed 4lth sat N& K (Y and hnne, dned o ci anh chous Na2SO- filteted and ctncentiated he residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl aceiate =10: 1) to give the title compound (35 g, 933% yield) as a yellow oil.

According to the analysis of related databases, 81927-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason Allan; PHADKE, Avinash S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (358 pag.)WO2017/35411; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 81927-55-1, These common heterocyclic compound, 81927-55-1, name is Benzyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of scheme 5-8 compound S1 (24 g, 0.136 mol) and benzyl 2,2,2-trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 mL) at room temperature was added trifluoromethanesulfonic anhydride (cat.1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (35 g, 93.3% yield) as a yellow oil.

Statistics shows that Benzyl 2,2,2-trichloroacetimidate is playing an increasingly important role. we look forward to future research findings about 81927-55-1.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (508 pag.)WO2017/35409; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics