Category: 821-10-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 821-10-3, name is 1,4-Dichlorobut-2-yne, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1,4-Dichlorobut-2-yne

General procedure: K2CO3 (3a, 210 mg, 1.5 mmol) was added to a solution of b-ketosulfones 1a-p (0.5 mmol) in acetone (10 mL) at 25 C. The reaction mixture was stirred at 25 C for 10 min. 1,4-Dichloro-2-butyne (2, 68 mg, 0.55 mmol) was added to the reaction mixture at 25 C. The reaction mixture was stirred at 56 C for 8 h. The reaction mixture was cooled to 25 C and the solvent was concentrated. The residue was diluted with water (10 mL) and the mixture was extracted with CH2Cl2 (320 mL). The combined organic layers were washed with brine, dried, filtered and evaporated to afford crude product. Purification on silica gel (hexanes/EtOAc15/1e8/1) afforded 4a-p.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 821-10-3.

Reference:
Article; Chan, Chieh-Kai; Lu, Yi-Ju; Chang, Meng-Yang; Tetrahedron; vol. 71; 51; (2015); p. 9544 – 9549;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 821-10-3, name is 1,4-Dichlorobut-2-yne, A new synthetic method of this compound is introduced below., Product Details of 821-10-3

To a solution of compound 15G (1.0 g, 1.9 mmol, 1.0 eq) in DMF (15 mL) was added 1 ,4-dichlorobut-2-yne (490 mg, 4.0 mmol, 2.0 eq), K2C03 (800 mg, 5.8 mmol, 3.0 eq) and Nal (290 mg, 1.9 mmol, 1.0 eq). The mixture was stirred at 80 C for 3 hours before it was concentrated under reduced pressure. The residue was purified by column chromatography (hexanes/EtOAc =10/1 to 5/1 ) to give compound 62A (900 mg, 77%).ESI-MS: [M+H]+: 603

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; HECKER, Scott; REDDY, Raja, K.; (198 pag.)WO2016/149393; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 821-10-3, name is 1,4-Dichlorobut-2-yne, A new synthetic method of this compound is introduced below., SDS of cas: 821-10-3

[0038] The 1 ,4-dichloro-2-butyne 14 of Example 2 is de-halogenated by base promoted elimination of HC1 to produce diacetylene 15. A mixture of 4 M aqueous potassium hydroxide (3 equivalents) and dimethyl sulfoxide (1 mL per 16 mmol potassium hydroxide) is heated to about 70-75 C. 1 ,4-dichloro-2-butyne (1 equivalent) is added slowly to the mixture while bubbling argon through the solution. The volatile product is directed through a series of two gas washing bottles containing dilute aqueous potassium hydroxide followed by two calcium chloride drying tubes and into a vessel containing anhydrous tetrahydrofuran cooled in an ice-calcium chloride bath to yield a tetrahydrofuran solution of diacetylene 15.

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EMPIRE TECHNOLOGY DEVELOPMENT LLC; KLEIN, Josef Peter; WO2015/60862; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 821-10-3, These common heterocyclic compound, 821-10-3, name is 1,4-Dichlorobut-2-yne, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of diyne (50 mg) in dry solvent (5mL) in microwave reaction vessel propargyl halide 7b/c/e/f (2 equiv.) and Mo(CO)6 (5 mol%) were added andthe reaction mixture was irradiated in a CEM Discover microwave synthesizer for10 min. under standard conditions. Afterthe completion of reaction (TLC monitoring), the solvent was concentrated atreduced pressure and the crude product was purified by silica gel columnchromatography

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kotha, Sambasivarao; Sreevani, Gaddamedi; Tetrahedron Letters; vol. 56; 43; (2015); p. 5903 – 5908;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 821-10-3,Some common heterocyclic compound, 821-10-3, name is 1,4-Dichlorobut-2-yne, molecular formula is C4H4Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: K2CO3 (3a, 210 mg, 1.5 mmol) was added to a solution of b-ketoesters 5a-c (0.5 mmol) in acetone (10 mL) at 25 C. The reaction mixture was stirred at 25 C for 10 min. 1,4-Dichloro-2-butyne (2, 68 mg, 0.55 mmol) was added to the reaction mixture at reflux. The reaction mixture was stirred at 56 C for 8 h. The reaction mixture was cooled to 25 C and the solvent was concentrated. The residue was diluted with water (10 mL) and the mixture was extracted with CH2Cl2 (320 mL). The combined organic layers were washed with brine, dried, filtered and evaporated to afford crude product. Purification on silica gel (hexanes/EtOAc20/1e10/1) afforded 6a-c.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dichlorobut-2-yne, its application will become more common.

Reference:
Article; Chan, Chieh-Kai; Lu, Yi-Ju; Chang, Meng-Yang; Tetrahedron; vol. 71; 51; (2015); p. 9544 – 9549;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 821-10-3, name is 1,4-Dichlorobut-2-yne, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,4-Dichlorobut-2-yne

General procedure: The [2 + 2 + 2] cycloaddition was performed in a similar manner as described in [3]. In brief, to a solution of diyne (1 equiv) and propargyl halide (2 equiv) in dry acetonitrile (5 mL), Mo(CO)6 (5 mol %) was added and the reaction mixture was stirred under MWI conditions for 10-15 min. After completion of the reaction (TLC), the reaction mixture was concentrated at reduced pressure and the crude product was purified by silica gel column chromatography using EtOAc/petroleum ether 5:95 to 30:70 to give the [2 + 2 + 2] cyclotrimerized compounds.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 821-10-3.

Reference:
Article; Kotha, Sambasivarao; Sreevani, Gaddamedi; Dzhemileva, Lilya U.; Yunusbaeva, Milyausha M.; Dzhemilev, Usein M.; D?yakonov, Vladimir A.; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 2774 – 2781;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 821-10-3,Some common heterocyclic compound, 821-10-3, name is 1,4-Dichlorobut-2-yne, molecular formula is C4H4Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of diyne (50 mg) in dry solvent (5mL) in microwave reaction vessel propargyl halide 7b/c/e/f (2 equiv.) and Mo(CO)6 (5 mol%) were added andthe reaction mixture was irradiated in a CEM Discover microwave synthesizer for10 min. under standard conditions. Afterthe completion of reaction (TLC monitoring), the solvent was concentrated atreduced pressure and the crude product was purified by silica gel columnchromatography

The synthetic route of 821-10-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kotha, Sambasivarao; Sreevani, Gaddamedi; Tetrahedron Letters; vol. 56; 43; (2015); p. 5903 – 5908;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics