Category: 82711-97-5

On April 22, 2022, Thorat, Vijaykumar H.; Tsai, Yu-Lin; Huang, Yong-Ran; Cheng, Chien-Hong; Hsieh, Jen-Chieh published an article.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride The title of the article was Nickel-Catalyzed Denitrogenative Cyclization of 1,2,3,4-Benzothiatriazin-1,1(2H)-dioxides with Arynes To Synthesize Biaryl Sultams. And the article contained the following:

The nickel-catalyzed denitrogenative cyclization reaction of 1,2,3,4-benzothiatriazine-1,1-dioxides with arynes to generate the polysubstituted biaryl sultams with tolerance of a wide diversity of substituents on every subunit was reported. The mechanistic study indicated that the reaction was initiated by the formation of a diradical species, which reacted with a nickel complex to form a nickelacycle intermediate and carried out the subsequent cyclization through insertion of an aryne. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to biaryl fuse sultam preparation, benzothiatriazine aryne nickel catalyst denitrogenative heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 7, 2010, Zhersh, Sergey; Lukin, Oleg; Matvienko, Vitaly; Tolmachev, Andrey published an article.Related Products of 82711-97-5 The title of the article was Synthesis of isomeric fluoronitrobenzene-sulfonyl chlorides. And the article contained the following:

The synthesis of five hitherto unknown isomeric fluoronitrobenzenesulfonyl chlorides is described. The compounds are prepared from difluoronitrobenzenes by a two-step procedure. In the first step the starting compounds undergo a regioselective reaction with phenylmethanethiol giving rise to the corresponding thioethers. The oxidative cleavage of the latter with chlorine results in the sulfonyl chlorides in good yields. One example of a threefold sequential functionalization of 2-fluoro-6-nitrobenzenesulfonyl chloride showing the synthetic utility of the title compounds is provided. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Related Products of 82711-97-5

The Article related to fluoronitrobenzenesulfonyl chloride preparation, benzenesulfonyl chloride fluoronitro preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Related Products of 82711-97-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Courtin, Alfred published an article in 1982, the title of the article was Syntheses of sulfonated derivatives of 4-fluoroaniline.Application In Synthesis of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride And the article contains the following content:

Thermolysis of 4-FC6H4NH2.H2SO4 gave the sulfonated derivative I (R = NH2, R1 = SO3H), the structure of which was confirmed by successive diazotization, chlorosulfonylation, hydrolysis, and Fe-HCl reduction of nitroaniline I (R = NO2, R1 = NH2). Sulfonating acetanilide II (R2 = NHAc, R3 = H) with oleum and hydrolyzing gave benzenesulfonic acid II (R2 = NH2, R3 = SO3H), the structure of which was confirmed by treating II (R2 = NO2, R3 = NH2) analogously to I (R = NO2, R1 = NH2). Sulfonating I (R = NH2, R1 = H) with oleum gave impure II (R2 = NH2, R3 = SO3H). Sulfonating I (R = NO2, R1 = H) with oleum also gave II (R2 = NO2, R3 = SO3H). The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Application In Synthesis of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to sulfonated fluoroaniline, aniline fluorosulfo, benzenesulfonic acid aminofluoro, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Application In Synthesis of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gong, Ya-Ping; Tang, Long-Qian; Liu, Tong-Shen; Liu, Zhao-Peng published an article in 2019, the title of the article was Synthesis and evaluation of novel 2H-benzo[e]-[1,2,4]thiadiazine 1,1-dioxide derivatives as PI3Kδ inhibitors.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride And the article contains the following content:

The carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I [R1 = H, F; R2 = Ph, 3-methoxyphenyl, 6-methoxypyridin-3-yl, 1H-indol-5-yl, etc.] as PI3Kδ inhibitors was replaced. After the reduction of nitro group in N-(2,6-dimethylphenyl)-2-nitrobenzenesulfonamide and N-(2,6-dimethylphenyl)-2-nitro-5-fluorobenzenesulfonamide, the resulting 2-aminobenzenesulfonamides were reacted with tri-Me orthoacetate to give the 3-methyl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives After bromination of the 3-Me group, the nucleophilic substitution with the 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine provided the resp. iodide derivatives, which were further reacted with a series of arylboronic acids via Suzuki coupling to furnish the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I. In agreement with the quinazolinone derivatives, the introduction of a 5-indolyl or 3,4-dimethoxyphenyl at the affinity pocket generated the most potent analogs I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] with the IC50 values of 217 to 266 nM, resp. In comparison with the quinazolinone lead compounds I these 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives exhibited much decreased PI3Kδ inhibitory potency, but maintained the high selectivity over other PI3K isoforms. Unlike the quinazolinone lead compound I that was a dual PI3Kδ/γ inhibitor, the benzothiadiazine 1,1-dioxide I [R1 = H; R2 = 3,4-dimethoxyphenyl] was more than 21-fold selective over PI3Kγ. Moreover, the introducing of a fluorine atom at the 7-position of the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide core, I in general, was not favored for the PI3Kδ inhibitory activity. In agreement with their high PI3Kδ selectivity, I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] significantly inhibited the SU-DHL-6 cell proliferation. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to pyrazolopyrimidinylmethyl dimethylphenyl benzothiadiazine dioxide preparation phosphatidylinositol kinase antitumor sar, 2h-benzo[e][1,2,4]thiadiazine 1,1-dioxide, pi3ks, pi3kδ inhibitors, anticancer, anticancer agents and other aspects.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 23, 2012, Buhr, Wilm; Burckhardt, Susanna; Duerrenberger, Franz; Funk, Felix; Geisser, Peter Otto; Corden, Vincent Anthony; Courtney, Stephen Martin; Davenport, Tara; Slack, Mark; Ridgill, Mark Peter; Yarnold, Christopher John; Dawson, Graham; Boyce, Susan; Ellenbroek, Albertus Antonius published a patent.Electric Literature of 82711-97-5 The title of the patent was Novel sulfonaminoquinoline derivatives as hepcidin antagonists and their preparation and use in the treatment of iron metabolic disorders. And the patent contained the following:

The invention is related to the preparation of title compounds I [R1-6 = independently H, halo, CN, (un)substituted aroxy, heterocyclyl, etc.; R7 = H, (un)substituted alk(en/yn)yl, aryl, etc.; R8 = H, NH2 and derivatives, OH and derivatives, etc.; or R6 and R8 together form a residue II or III; X = C, N; R9-12 = independently H, NO2, CO2H and derivatives, etc.; R13 = H, (un)substituted aryl, acyl, alkyl, etc.; R14, R15 = H, halo, (un)substituted alkoxycarbonyl, aminosulfonyl, etc.] and their pharmaceutically acceptable salts as hepcidin antagonists, pharmaceutical compositions containing them, and to their use as medicaments, in particular for treating iron metabolism disorders, for example, iron deficiency diseases and anemias, in particular anemias combined with chronic inflammation diseases and anemia of inflammation. Thus, reaction of 7-methyl-8-nitroquinoline with 1,1-dimethoxy-N,N-dimethylmethanamine, oxidation of dimethyl[(E)-2-(8-nitroquinolin-7-yl)ethenyl]amine, reductive amination of 8-nitroquinoline-7-carboxaldehyde with aniline, Pd/C hydrogenation of N-[(8-nitroquinolin-7-yl)methyl]phenylamine and cyclization of [7-[(phenylamino)methyl]quinolin-8-yl]amine with 1-[(1H-imidazol-1-yl)sulfonyl]-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate gave IV. Selected I were evaluated for their hepcidin antagonistic activity. From the assay, it was determined that compound IV exhibited an IC50 value of 0.46 μM towards ferroportin. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Electric Literature of 82711-97-5

The Article related to sulfonaminoquinoline preparation hepcidin antagonist treatment iron metabolic disorder, dioxothiatriazaphenanthrene dioxothiadiazachrysene dioxoazacyclopentanaphthalene dioxothiatriazachrysene preparation anemia hepcidin antagonist and other aspects.Electric Literature of 82711-97-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics