Category: 84859-27-8

Some common heterocyclic compound, 84859-27-8, name is 5-Chloro-N1-methylbenzene-1,2-diamine, molecular formula is C7H9ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 84859-27-8

Step 3: 6-Chloro-2-(4-diethoxymethyl-pyridin-3-yl)-1-methyl-1 H-benzoimidazole (37c)A solution of 5-chloro-N1-methylbenzene-1,2-diamine (383 mg, 2.446 mmol) and 4- diethoxymethyl-pyrid’ine-3-carbaldehyde (512 mg, 2.446 mmol) in 1 ,4-dioxane (20 mL) was heated to 75 C overnight. The mixture was cooled to room temperature and concentrated in vacuo. The residue was purified by silica gel flash chromatography employing heptane-ethyl acetate (1:1) to give of 6-chloro-2-(4-diethoxymethyl-pyridin-3-yl)-1 -methyl- 1H- benzoimidazole.MS (ESI) m/z 346.0 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 84859-27-8, its application will become more common.

Reference:
Patent; NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien; WO2011/61168; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 84859-27-8, name is 5-Chloro-N1-methylbenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Chloro-N1-methylbenzene-1,2-diamine

6-Chloro-l-methyl-l,3-dihydro-benzoimidazol-2-one (61): A mixture of 4- chloro-N2-methyl-benzene-l,2-diamine (60) (100 mg, 0.64 mmol, 1 eq), triphosgene (95 mg, PATENT Attorney Docket No.: 019934-00601 OUS0.32 mmol, 0.5 eq), TEA (0.26 ml) in THF(2 ml) was stirred at rt for 4 hours. The reaction solution was washed with ethyl acetate and concentrated to provide 6-chloro-l -methyl- 1,3- dihydro-benzoimidazol-2-one (61).

The synthetic route of 5-Chloro-N1-methylbenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2007/22257; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 84859-27-8, The chemical industry reduces the impact on the environment during synthesis 84859-27-8, name is 5-Chloro-N1-methylbenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

General procedure: General procedure for the synthesis of 2-mercaptobenzimidazole derivatives (18-34): the proper 1,2-phenylenediamine 1-17 (16 mmol) was added over a stirred solution of ethanol (50 mL), water (5 mL), potassium hydroxide (19.2 mmol) and carbon disulfide (19.2 mmol). The mixture was heated overnight under a N2 atmosphere at 50 C. The cold reaction mixture was then neutralized with acetic acid and poured into 250 mL of cold water for complete precipitation. The solid was separated and dried using vacuum filtration. The crude product was purified by recrystallization, adding norite to the solvent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-N1-methylbenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Perez-Villanueva, Jaime; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Mendez-Cuesta, Carlos; Mendez-Lucio, Oscar; Hernandez-Luis, Francisco; Castillo, Rafael; Bioorganic and Medicinal Chemistry Letters; vol. 23; 14; (2013); p. 4221 – 4224;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics