Category: 849052-15-9

Carreras, Javier published the artcileExploiting the π-acceptor properties of carbene-stabilized phosphorus centered trications [L₃P] ³⁺: applications in Pt(II) catalysis, Computed Properties of 849052-15-9, the publication is Journal of the American Chemical Society (2012), 134(40), 16753-16758, database is CAplus and MEDLINE.

2-Ethynylbiaryls undergo 6-endo-dig cyclization into annulated phenanthrenes and helicenes, catalyzed by platinum complex with electron-accepting tricationic cyclopropenylium phosphine, [(Me₂N)₂C₃⁺]₃P (1), [[(Me₂N)₂C₃⁺]₃PPtCl₃][ClO₄]₂ (3). The complex 3 is a bench-stable compound, easily available from reaction of K₂PtCl₄ with 1; the complex 3 is an excellent catalyst for cyclization of 2-ethynylbiaryls, when activated by Ag[CB₁₁H₆Cl₆]. Complexation of platinum complex (3) with alkyne is approx. 6 kcal mol^-1 more favorable, than with triphenylphosphine analog [(PPh₃)PtCl₃]^–. This constitutes the first example ever reported of using a P₁-centered trication as ligand in catalysis. The strong π-acceptor character of 1 that derives from its three pos. charges substantially increases the intrinsic π-acidity of Pt in complex 1·PtCl₂ and dramatically enhances its ability to activate π-systems toward nucleophilic attack. As a consequence, a remarkable acceleration of the model transformation is observed when compared with other classical π-acceptor ligands such as P(OPh)₃ or P(C₆F₅)₃. Moreover, the employment of 1 as ligand also expands the scope of this reaction to previously inaccessible substitution patterns. Kinetic studies and deuterium labeling experiments as well as d. functional theory (DFT) calculations were performed in order to explain these findings.

Journal of the American Chemical Society published new progress about 849052-15-9. 849052-15-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, and the molecular formula is C15H16BClO3, Computed Properties of 849052-15-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalcic, Filip published the artcilePolysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE₂ Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema, Application of (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, the publication is ChemMedChem (2020), 15(15), 1398-1407, database is CAplus and MEDLINE.

We report an extensive structure-activity relationship optimization of polysubstituted pyrimidines that led to the discovery of 5-butyl-4-(4-benzyloxyphenyl)-6-phenylpyrimidin-2-amine, and its difluorinated analog. These compounds are sub-micromolar inhibitors of PGE₂ production (IC₅₀ as low as 12 nM). In order to identify the mol. target of anti-inflammatory pyrimidines, we performed extensive studies including enzymic assays, homol. modeling and docking. The difluorinated analog simultaneously inhibits two key enzymes of the arachidonic acid cascade, namely mPGES-1 and COX-2, with mPGES-1 inhibition being the principal mechanism of action. Other pyrimidines studied are potent mPGES-1 inhibitors with no observed inhibition of COX-1/2 enzymes. Moreover, the two most potent compounds proved to be significantly effective in vivo in a model of acute inflammation, suppressing carrageenan-induced rat paw edema by 36 and 46%. The promising results of this study warrant further preclin. evaluation of selected anti-inflammatory candidates.

ChemMedChem published new progress about 849052-15-9. 849052-15-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid, and the molecular formula is C15H16BClO3, Application of (4-((2-Chlorobenzyl)oxy)-3,5-dimethylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics