Category: 863111-48-2

Adding a certain compound to certain chemical reactions, such as: 863111-48-2, name is 2-Bromo-5-chloro-4-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 863111-48-2, SDS of cas: 863111-48-2

Example 158: (R S)-3-(5-Chloro-2-f(E)-3-f3-(4-fluoro-benzyl(at)3.8-diaza-bic cly o(at)3.2.11oct-8-yll- 3-oxo-roDenvl)-4-trifluoromethvl-Dhenyll-5-methvl-imidazolidine-2,4-dione; a) (R)-2-(at)3-(2-Bromo-5-chloro-4-trifluoromethvl-ahenyl)-ureidol-propionic acid methyl ester; To a solution of 2-bromo-5-chloro-4-trifluoromethoxyaniline (0.5 g, 1.8 mmol) and triethylamine (0.63 ml, 4.6 mmol) in 12 ml chloroform is added triphosgene (0.22 g, 0.73 mmol) in one portion. After stirring at room temperature for 5 hours first triethylamine (0.30 ml, 2.2 mmol) then D-alanine methyl ester x HCI (0.25g, 1.8 mmol) is added and the mixture is stirred at 65 C for 16 hours. The reaction mixture is poured onto sodium bicarbonate solution followed by extraction with ethylacetate, drying and concentration. Chromatography gave 0.34 g (0.9 mmol, 50%) of the title compound. 1H-NMR (400MHz; DMSO-d6), No. (ppm) : 1.34 (d, 3H), 3.66 (s, 3H), 4.25 (dq, 1H), 7.94 (d, 1 H), 7.99 (s, 1H), 8.42 (s, 1 H), 8.48 (s, 1 H). MS (m/z) ESI-: 401 (100, M-H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-chloro-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/103054; (2005); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 863111-48-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 863111-48-2, name is 2-Bromo-5-chloro-4-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Boc2O (53.3 ml, 240 mmol) was added to a suspension of 2-bromo-5-chloro-4-trifluoromethyl-phenylamine (26.8 g, 98 mmol) and DMAP (2.39 g, 20 mmol) in THF (500 ml), and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane) to yield 4-(bis(tert-butoxycarbonyl)amino)-5-bromo-2-chloro-1-trifluoromethylbenzene (45.9 g, 99%) as a colorless solid. HPLC retention time: 1.12 min (analysis condition A) 1H-NMR (400 MHz, CDCl3) delta: 7.92 (1H, s), 7.40 (1H, s), 1.43 (18H, s).

The synthetic route of 2-Bromo-5-chloro-4-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; MURATA, Takeshi; NIIZUMA, Satoshi; HARA, Sousuke; KAWADA, Hatsuo; HADA, Kihito; SHIMADA, Hideaki; TANAKA, Hiroshi; NAKANISHI, Yoshito; EP2842939; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics