Category: 864725-22-4

Qu, Shuhao published the artcileDesign, synthesis and insecticidal activity of 3-arylisoxazoline-N-alkylpyrazole-5-carboxamide derivatives against Tetranychus urticae koch, Category: chlorides-buliding-blocks, the publication is Heterocycles (2022), 104(3), 512-523, database is CAplus.

Starting from Et 5,5-dimethoxy-2,4-dioxopentanoate 2,3-arylisoxazoline-N-alkylpyrazole-5-carboxamide derivatives I (R = HNCH₂C(O)NHCH₂CF₃, 4-t-BuC₆H₄CH₂NH, 4-EtOC₆H₄CH₂NH, 4-MeC₆H₄OC₆H₄CH₂NH) were designed and synthesized with the key steps of 1,3-dipolar cycloaddition and EDCl coupling. Their insecticidal activity against Tetranychus urticae Koch was further evaluated and the results indicated that, compared with Fluralaner, all compounds showed moderate and less activity at 500 mg/L and 250 mg/L, resp. This study complements the structure-activity relationship of N-alkylpyrazole-5-carboxamides to Fluralaner, giving further guidance in Fluralaner-based pesticide drug design and discovery.

Heterocycles published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zeng, Hao published the artcileThree component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols, SDS of cas: 864725-22-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(46), 6241-6244, database is CAplus and MEDLINE.

The three component hydroxyletherification and hydroxylazidation reactions of (trifluoromethyl)alkenes RC(=CH₂)CF₃ (R = Ph, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.) are reported, providing various useful α-trifluoromethyl β-heteroatom substituted tertiary alcs. e.g., I in high yields. The ipso-defluorooxylation of (trifluoromethyl)alkenes with oximes e.g., 2-phenyl-3,3,3-trifluoropropene is completely inhibited. A pesticidal active compound could be synthesized with this method.

Chemical Communications (Cambridge, United Kingdom) published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C6H3ClFNO2, SDS of cas: 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Shi-sheng published the artcileDesign, synthesis, and insecticidal and fungicidal activities of quaternary ammonium salt derivatives of a triazolyphenyl isoxazoline insecticide, Category: chlorides-buliding-blocks, the publication is Pest Management Science (2022), 78(5), 2011-2021, database is CAplus and MEDLINE.

Insect pests seriously decrease the yield and quality of agricultural crops. Resistance to commonly used insecticides is increasingly undermining their effectiveness, and therefore the development of agents with novel modes of action is desirable. Isoxazolines are a new class of insecticides that act on γ-aminobutyric acid (GABA) gated chloride channels. In this work, we used the highly active 4-triazolyphenyl isoxazoline DP-9 as a parent structure to design and synthesize a series of quaternary ammonium salt (QAS) derivatives, and we systematically evaluated their insecticidal and antifungal activities. RESULTS : Many of the synthesized QASs exhibit insecticidal activities equivalent to or higher than that of DP-9. In particular, compounds I-31 (93%, 0.00005 mg/L) and I-34 (80%, 0.00001 mg/L) showed insecticidal activities against diamondback moth larvae that were 2-10 times higher than those of fluralaner (70%, 0.0001 mg/L) and DP-9 (80%, 0.0001 mg/L), in addition to showing excellent activities against oriental armyworm, fall armyworm, cotton bollworm, corn borer, and mosquito larvae. Furthermore, all of the synthesized compounds also showed broad-spectrum fungicidal activities. The insecticidal activities of QAS derivatives of DP-9 were the same as or better than the activity of DP-9. Compounds I-31 and I-34 showed better insecticidal activities against diamondback moth larvae than fluralaner and DP-9, and thus are promising new candidates for insecticide research.

Pest Management Science published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Yingying published the artcileDouble allylic defluorinative alkylation of 1,1-bisnucleophiles with (trifluoromethyl)alkenes: construction of all-carbon quaternary centers, Application In Synthesis of 864725-22-4, the publication is Organic Chemistry Frontiers (2020), 7(10), 1260-1265, database is CAplus.

A double allylic defluorinative alkylation reaction of 1,1-bisnucleophiles such as C₆H₅CH₂ R (R = H, Ph, C(O) C₆H₅, C(O)OEt, etc.), nitriles R¹CH₂CN (R¹ = Ph, thiophen-2-yl, n-decyl, etc.)and indolin-2-one with (trifluoromethyl)alkenes CH₂=C(R²)CF₃ (R² = Ph, naphthalen-2-yl, pyridin-3-yl, etc.) is reported that occurs via the exclusively regioselective SN2 reaction. Various aliphatic nitriles, esters, and indolin-2-one derivatives could serve as 1,1-bisnucleophiles, delivering diverse attractive sym. gem-difluoroalkene substituted products e.g., I in high yields via the construction of all-carbon quaternary centers. Interestingly, the chemoselective SNV reaction between gem-difluoroalkenes and nucleophiles is completely inhibited. The nitrile group might help to stabilize the α-carbanion intermediates.

Organic Chemistry Frontiers published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Congyu published the artcileDefluorinative C(sp³)-P Bond Construction for the Synthesis of Phosphorylation gem-Difluoroalkenes under Catalyst- and Oxidant-Free Conditions, Application In Synthesis of 864725-22-4, the publication is Chemistry – An Asian Journal (2019), 14(15), 2584-2587, database is CAplus and MEDLINE.

Defluorinative C(sp³)-P bond formation of α-trifluoromethyl alkenes with phosphine oxides or phosphonates were achieved under catalyst- and oxidant-free conditions, giving phosphorylation gem-difluoroalkenes as products. α-Trifluoromethyl alkenes bearing various of aryl substituents such as halogen, cyano, ester and heterocyclic groups are available in this transformation. The results of control experiments demonstrated that the mechanism of dehydrogenative/defluorinative cross-coupling reactions was not a radical route, but might be an S_N2′ process involving phosphine oxide anion.

Chemistry – An Asian Journal published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application In Synthesis of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Ming published the artcileInsecticidal quinoline and isoquinoline isoxazolines, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(16), 4026-4030, database is CAplus and MEDLINE.

A series of quinoline and isoquinoline isoxazolines have been designed as pesticides for crop protection. Herein we reported the chem. synthesis, biol. activity and structure-activity relationships. The isoquinoline derivative, such as I, is discovered as potent new class of isoxazoline insecticide which is competitive with com. insecticide indoxacarb.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C44H28ClFeN4, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong-Kang published the artcileNovel synthesis of isoxazoline indolizine amides for potential application to tropical diseases, Related Products of chlorides-buliding-blocks, the publication is Tetrahedron Letters (2014), 55(11), 1936-1938, database is CAplus.

Synthetically challenging isoxazoline indolizine amide compounds were designed and prepared for potential application to tropical diseases. Indolizine core structures were synthesized strategically as common intermediates for efficient derivatization. The chem. for the syntheses of 8-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)indolizine-5-carboxamide and 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-indolizine-8-carboxamide is described in this Letter.

Tetrahedron Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C44H28ClFeN4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong-Kang published the artcileDiscovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(23), 5589-5593, database is CAplus and MEDLINE.

A novel series of isoxazoline benzoxaborole small mols. was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the ectoparasiticide activity against ticks and fleas. The study identified an orally bioavailable mol., (S)-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol (38, AN8030), which was long lasting in dogs (t_1/2 = 22 days). Compound 38 demonstrated 97.6% therapeutic effectiveness within 24 h of treatment, with residual efficacy of 95.3% against American dog ticks (Dermacentor variabilis) on day 30% and 100% against cat fleas (Ctenocephalides felis) on day 32 after a single oral dose at 50 mg/kg in dogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C10H10O2, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tian, Qingqiang published the artcileSelective C-F Bond Etherification of Trifluoromethylalkenes with Phenols, HPLC of Formula: 864725-22-4, the publication is Journal of Organic Chemistry (2022), 87(16), 10908-10916, database is CAplus and MEDLINE.

A novel protocol for the C-F bond etherification of trifluoromethylalkenes and phenols was reported. A variety of alkenyl difluoroaryloxy ethers were obtained with good chemoselectivity and functional group tolerance. DFT calculation results and control experiments suggested that metal ion Cs⁺ might be involved in this defluorooxylation. Furthermore, the desired product exhibited a good insecticidal activity.

Journal of Organic Chemistry published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H8O4, HPLC of Formula: 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Xin published the artcileElectrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes, Formula: C9H5Cl2F3, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(70), 8750-8753, database is CAplus and MEDLINE.

Radical fluoroalkylation of alkenes has been developed by electrochem. reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily underwent hydrofluoroalkylation in good to excellent yields. This chem. represents the first example of electrochem. generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds

Chemical Communications (Cambridge, United Kingdom) published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C8H13NO3, Formula: C9H5Cl2F3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics