Category: 864725-22-4

Wang, Yong published the artcileSynthesis of 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl) benzene, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Huaxue Shiji (2017), 39(11), 1237-1240, 1243, database is CAplus.

In this work, 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone was synthesized by reaction of Et trifluoroacetate with the Grignard reagent, which was obtained by reaction of 3,5-dichlorobromobenzene, magnesium and diisobutyl aluminum hydride. 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanone was then reacted with methyltriphenylphosphonium iodide in the presence of potassium t-butoxide to give the desired product 1,3-dichloro-5-(3, 3, 3-trifluoroprop-1-en-2-yl) benzene. Above two compounds were confirmed by IR, MS, UV, ¹HNMR and ¹³CNMR. The synthetic route has the advantages of simple operation, mild reaction condition, cheap and easy access to raw materials, green environmental protection and low cost.

Huaxue Shiji published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C33H22N4, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Jingjing published the artcileDBN-Mediated Addition Reaction of α-(Trifluoromethyl)styrenes with Diazoles, Triazoles, Tetrazoles, and Primary, Secondary, and Secondary Cyclic Amines, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Organic Letters (2022), 24(12), 2299-2304, database is CAplus and MEDLINE.

A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various β-trifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.

Organic Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Recommanded Product: 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Chengxi published the artcileChemo- and regioselective defluorinative annulation of (trifluoromethyl)alkenes with pyrazolones: synthesis and insecticidal activity of 6-fluoro-1,4-dihydropyrano[2,3-c]pyrazoles, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Organic Chemistry Frontiers (2022), 9(17), 4692-4698, database is CAplus.

The chemo- and regioselective defluorinative [3 + 3] annulation of (trifluoromethyl)alkenes and pyrazolones was reported that gives rise to various useful 6-fluoro-1,4-dihydropyrano[2,3-c]pyrazoles I [R = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; R¹ = Ph, 3-MeC₆H₄, 4-ClC₆H₄, etc.; R² = Me, Et, Bn, etc.] in high yields. This reaction distinguished the different nucleophilic sites of pyrazolones and featured mild conditions, a broad substrate scope, and gram-scalability. A simple derivation of the obtained 6-fluoro-1,4-dihydropyrano[2,3-c]pyrazoles efficiently afforded diverse useful compounds Significantly, compound I [R = 4-F₃CC₆H₄, R¹ = 2-ClC₆H₄, R² = Me] exhibited up to 100% insecticidal activity against Plutella xylostella, which was a destructive pest worldwide. Mechanism studies indicated that this reaction proceeded via a chemo- and regioselective S_N2’/S_NV pathway and that the double defluorinative alkylation of pyrazolones with (trifluoromethyl)alkenes was completely inhibited.

Organic Chemistry Frontiers published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Safety of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fanfoni, Lidia published the artcileEfficient synthesis of new fluorinated building blocks by means of hydroformylation, Quality Control of 864725-22-4, the publication is Chimia (2014), 68(6), 371-377, database is CAplus and MEDLINE.

The hydroformylation reactions of fluorinated olefins were reviewed and added new results from the research group. The particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.

Chimia published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yue, Wen-Jun published the artcileSite-Selective Defluorinative sp³ C-H Alkylation of Secondary Amides, Synthetic Route of 864725-22-4, the publication is Journal of the American Chemical Society (2021), 143(17), 6395-6400, database is CAplus and MEDLINE.

A site-selective defluorinative sp³ C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp³ sites was disclosed. This protocol was distinguished by its mild conditions, wide scope and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

Journal of the American Chemical Society published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C12H10F2Si, Synthetic Route of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lahm, George P. published the artcile4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 3001-3006, database is CAplus and MEDLINE.

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biol. activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides e. g., I.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Curtis, Michael P. published the artcileThe discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle, Quality Control of 864725-22-4, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5011-5014, database is CAplus and MEDLINE.

Hematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since current treatments such as organophosphates and pyrethroids suffer from field resistance. Isoxazoline oxime ethers represent a new class of γ-aminobutyric acid (GABA) receptor channel blockers which show good activity (LD⁹⁰ = 1.0 μg/mL) against horn flies in an in vitro feed assay and have demonstrated efficacy (>90% reduction at 1.0 mg/kg) as a topical treatment in a field study.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics