Category: 866-23-9

Villemin, Didier published the artcileAddition of diethyl trichloromethylphosphonate to olefins catalyzed by copper complexes, SDS of cas: 866-23-9, the publication is Tetrahedron Letters (1994), 35(21), 3537-8, database is CAplus.

R¹R²CClCH₂CCl₂P(O)(OEt)₂ (e.g., R¹ = CO₂Et, R² = H) were prepared in 31-65% yields by treating R¹R²C:CH₂ with Cl₃CP(O)(OEt)₂ catalyzed by Cu amine complexes.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H8BFO2, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Diziere, Rachel published the artcileA new simple method for the synthesis of 1-alkynylphosphonates using (EtO)₂P(O)CCl₃ as precursor, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (1996), 37(11), 1863-6, database is CAplus.

1-Alkynylphosphonates, (EtO)₂P(O)CCR (R = Ph, 4-Me₂NC₆H₄, 2-pyridyl, 2-thienyl, etc.), were obtained from (EtO)₂P(O)CCl₃ and aldehydes in a 1-pot procedure. It involves the formation of α-chlorovinyl phosphonate intermediates (E- and Z-isomers), (EtO)₂P(O)CHCl:CHR, by a Peterson olefination reaction followed by dehydrochlorination with LiHMDS.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Teulade, Marie Paule published the artcileα-Lithiated O,O-diethyl [chloro(trimethylsilyl)methyl]phosphonate. I. Preparation and properties, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Journal of Organometallic Chemistry (1988), 338(3), 295-303, database is CAplus.

Silylation of either (EtO)₂P(O)CH₂Cl or (EtO)₂P(O)CCl₃ in the presence of excess BuLi leads to the quant. generation of (EtO)₂P(O)CClLiSiMe₃. This stable type of anion can be protonated, deuterated, or alkylated. Compounds thus obtained can be desilylated in basic medium, or used for the preparation of α-bromo and α-iodo phosphonates after halogen-metal exchange. E.g., treating (EtO)₂P(O)CRClSiMe₃ (R = Me, Et, Pr, allyl) with BuLi, then 1,2-diiodoethane or 1,2-dibromoethane gave (EtO)₂P(O)CRXSiMe₃ (X = iodo, Br, resp.). Condensation with aliphatic and aromatic aldehydes gives vinylphosphonates without stereochem. control.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C9H9BrO2, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karrenbrock, Friedhelm published the artcileCathodic formation of olefins from phosphonates, COA of Formula: C5H10Cl3O3P, the publication is Tetrahedron Letters (1979), 2915-16, database is CAplus.

Cathodic reduction of Cl₃CP(O)(OEt)₂ in the presence of RR¹CO [R = 4-MeOC₆H₄, CH₂:CMe, Me(CH₂)₄, R¹ = H; R = Et, R¹ = Me; R = R¹ = Bu; RR¹ = (CH₂)₄] gave 24-52% RCR¹:CCl₂. Similar reduction of (EtO)₂P(O)CCl₂CO₂Et in the presence of PhCHO or cyclohexanone gave 55% of a 40:60 mixture of E– and Z-PhCH:CClCO₂Et and 43% Et chlorocyclohexylideneacetate, resp.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ichikawa, Junji published the artcileHeck-type 5-endo–trig cyclizations promoted by vinylic fluorines: Ring-fluorinated indene and 3H-pyrrole syntheses from 1,1-difluoro 1-alkenes, Synthetic Route of 866-23-9, the publication is Journal of Fluorine Chemistry (2006), 127(4-5), 489-504, database is CAplus.

Arylpalladium or aminopalladium species bearing a 2,2-difluorovinyl group undergo an unusual 5-endo alkene insertion followed by β-fluorine elimination. These processes provide a facile access to ring-fluorinated 5-membered carbocyclic and heterocyclic compounds starting from an 2-(3,3-difluoroallyl)phenyl trifluoromethanesulfonate and 3,3-difluoroallyl ketone O-pentafluorobenzoyl oximes. In both systems, the two vinylic F atoms are essential for Heck-type 5-endo–trig cyclizations. The crystal structure of F₂C:CHCMe₂CPh:NOH is presented [monoclinic, space group P2₁/c, a 7.5652(18), b 6.3060(15), c 23.707(6) Å, V 1121.4(5) ų, Z 4].

Journal of Fluorine Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Synthetic Route of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tarakhovskii, M. L. published the artcileAnticholinesterase activity and toxicity of some phosphonate esters containing a trichloromethyl group, Formula: C5H10Cl3O3P, the publication is Fiziologicheski Aktivnye Veshchestva (1976), 33-6, database is CAplus.

Of 11 phosphonic acid esters tested [ROP:O(OR1)R2], the 2 compds, where R = Et, R1 = (CH2)4CCl3, R2 = Me and where R = R1 = Et, R2 = CCl3 had the greatest anticholinesterase activity, inhibiting the enzyme 50% at 8.3 × 10-7 and 7.6 × 10-6 mol/L, resp. The compound where R = R1 = Et, R2 = Me had no anticholinesterase activity and the remaining compounds inhibited the enzyme at concentrations ranging from 5.75 × 10-5 to 6.5 × 10-1 mol/L. The i.p. LD50 values in mice ranged from 720 to 2240 mg/kg, the most active anticholinesterase having the greatest toxicity and the inactive compound having the least. These compounds were less toxic than some presently used in medical practice.

Fiziologicheski Aktivnye Veshchestva published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C10H11NO4, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kodolov, V. I. published the artcileMechanism of the reaction of diethyl alkylphosphonates with hydroxyl-containing polyethers, Safety of Diethyltrichloromethylphosphonate, the publication is Vysokomolekulyarnye Soedineniya, Seriya A (1968), 10(11), 2541-9, database is CAplus.

Di-Et alkylor arylphosphonates are treated with OH-containing oligoethers to obtain products which are useful as additives possessing fire resistance in foamed plastics, glass reinforced plastics, and other materials. Di-Et phosphonate and methyl-, allyl-, trichloromethyl-, and phenylphosphonates are used, and the oligoethers are HO[CH2CH2O2CRCO]mOCH2CH2OH, where R = -CH2-CH2-, -CH:CH-, or -o-C6H4-, where m is 1-2. The compounds are heated at 160-80° under N. The quantity of condensate increases after 4-6 hrs. with the acid number increasing and the OH-group content decreasing. Chromatograms, kinetic data, and ir spectra are given for the products and discussed, and a mechanism for the reaction, based on the destruction of the oligoether by alcoholysis, followed by a proton-radical exchange between the oligoether and the Et Cellosolve formed is proposed.

Vysokomolekulyarnye Soedineniya, Seriya A published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, J. C. published the artcileThe methoxy-iminium cation issued from DMF in organic electrosynthesis: an electrophile and a supporting-electrolyte cation, Related Products of chlorides-buliding-blocks, the publication is Electrochimica Acta (1991), 36(5-6), 819-23, database is CAplus.

Electrophilic reactivity of the methoxy-iminium cation (I), resulting from the reaction between dimethyl sulfate and DMF, has been investigated towards electrogenerated carbanions produced by electroreduction of activated polyhalo compounds Controlled potential reduction of di-Et trichloromethylphosphonate (II) in the presence of three equivalent of I in DMF leads to the expected adduct (EtO)₂P(O)CCl₂-CH(NMe₂)OMe (60% yield). Galvanostatic reduction of II in the presence of two equivalent of I leads to mixtures of the enamine (EtO)₂P(O)CCl=CH(NM₂) and the ynamine (EtO)₂P(O)CCNMe₂; when acetic acid is added, a mixture of the enamine and the enol-ether (EtO)₂P(O)CCl=CH(OMe) is obtained. Lastly, the enamine can be synthesized with a 80% yield by electroreducing II in the presence of four equivalent of I in the same way, enamines (MeO₂C)₂C=CH(NMe₂) (40% yield) and (EtO₂C)CCl=CH(NMe₂) (50% yield) are obtained from the electroreduction of di-Me dibromomalonate or Et trichloroacetate, resp.

Electrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kukhar, V. P. published the artcileReactions of trialkyl phosphites with polyhalomethanes, Quality Control of 866-23-9, the publication is Zhurnal Obshchei Khimii (1979), 49(7), 1470-4, database is CAplus.

In the reaction of CCl₄, CBr₄, and CHCl₃ with (RO)₃P (R = Et, Pr), one, two or three halo atoms are replaceable depending on the corresponding reagents used. Thus, reaction of CCl₄ with 2 mols. (EtO)₃P gave [(EtO)₂P(O)]₂CCl₂ whereas with 4 mols (EtO)₃P it gave [(EtO)₂P(O)]₂CH₂, (EtO)₂P(O)Cl, CH₂:CH₂ and EtCl.

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, J. published the artcileSimple route from aldehydes to alkynes and 1-chloro-1-alkynes, SDS of cas: 866-23-9, the publication is Synthesis (1975), 458-61, database is CAplus.

Reaction of RCHO (R = e.g., Et2CH, cyclohexyl, MeCH:CH, PhCH:CH, substituted phenyl) with LiCCl2P(O)(OEt)2 in THF-ether gave 85-90% RCH:CCl2 which 1) with LiNEt2 in THF-ether gave RCCCl and 2) with EtLi or BuLi in THF-ether at -10 to -70° gave RCCLi which was hydrolyzed with aqueous H2SO4 to RCCH or alkylated with chlorodimethyl ether to give methoxymethyl derivatives (e.g., 1-cyclohexyl-3-methoxy-1-propyne).

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C18H35NO, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics