Category: 866-23-9

Gramstad, Thor published the artcileHydrogen bonding. XXIII. Interaction of chloroform with various phosphoryl compounds. Higuchi plot. Solvent effect, Application In Synthesis of 866-23-9, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1972), 28(7), 1405-13, database is CAplus.

The Higuchi plot has been used to evaluate the Kassocn., ΔH, and ΔS values for the 1:1 association between CHCl3 and 6 phosphoryl compounds ΔH forms a linear relation with the change in NMR chem. shift, Δδx, and with ir frequency shift, ΔvC-D measured with CDCl3. Also a linear relation exists between Taft σ* constant and ΔH. On replacing CCl4 with cyclohexane as solvent, the Kassocn. and ΔH values are increased considerably.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fitch, Steven J. published the artcileNuclear magnetic resonance study of the P-C(OH)-P to P-CO-P rearrangement: Tetraethyl-I-hydroxyalkylidenediphosphonates, COA of Formula: C5H10Cl3O3P, the publication is Journal of the American Chemical Society (1962), 1876-9, database is CAplus.

Compounds previously reported (Cade, CA 54, 264e) to have the structure RC(OH)[P(O)(OR’)₂]₂ (I) are found to be isomeric rearrangement products of I, RCH[P(O)(OR’)₂] [OP(O)(OR’)₂] (II). P³¹ and H¹ nuclear magnetic resonance (N.M.R.) spectra, infrared spectra, and chem. evidence support structure II. MeC(O)P(O)(OEt)₂ (30 g.) and 23 g. HP(O)(OEt)₂ (III) treated with a drop of NaOEt soluble produced an exothermic reaction. The product, on cooling overnight at 0°, gave hygroscopic crystals of I (R = Me, R’ = Et)(IV), m. 38.0-8.9°, P³¹ n.m.r. peak (in H₂O) at -20.8 p.p.m. (neg. values downfield from 85% orthophosphoric acid standard). The above reaction mixture held 30 hrs. at 50° and distilled gave mainly II (R = Me, R’ = Et) (V), b₀.₁ 130-6°, P³¹ n.m.r. peaks at -21.1 and + 1.7 p.p.m., previously reported as IV. IV heated 10 min. at 125° with NaOEt gave V. BzP(O)(OEt)₂ (242 g.), 138 g. III, and a trace of NaOEt heated 4 hrs. at 105° and distilled gave 55% II (R = Ph, R’ = Et), b₀.₁ 171-4°, n²⁵_D 1.4776, small mol. P³¹ n.m.r. peaks at -16.2 and +1.4 p.p.m. I (R = Ph, R’ = Et) could not be isolated at the lowest usable reaction temperature V, heated with PCl₅ in CCl₄ and hydrolyzed, gave H₃PO₄ and MeCHClPO₃H₂. IV and HCl gave I (R = Me, R’ = H), m. 155° (decomposition), P³¹ n.m.r. peaks at -23.0 p.p.m. The H¹ n.m.r. spectrum of IV showed 2 triplets in the methyl region (J = 7 and 16 cycles/sec.). A double resonance exp. showed that the smaller triplet arose from P-H coupling and that a downfield multiplet was resolved to a quartet. The Me region of V simplified to overlapping triplets and a small doublet under double resonance. The infrared spectrum of IV showed absorption at 3180 (OH), 1260 (P:O) and 1163 (POEt) cm.^-1 while anhydrous V had no absorption in the OH region.

Journal of the American Chemical Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Antczak, Monika I. published the artcileMild Synthesis of Organophosphorus Compounds: Reaction of Phosphorus-Containing Carbenoids with Organoboranes, Application of Diethyltrichloromethylphosphonate, the publication is Organic Letters (2008), 10(5), 977-980, database is CAplus and MEDLINE.

Organoboranes react with phosphorus-containing carbenoids to produce a variety of functionalized organophosphorus compounds under mild conditions. In some cases, selective migration of one group attached to boron can be observed Thus, reaction of (MeO)₂P(O)(CH₂N₂) with Bu₃B in THF/Et₂O at room temperature for 1h followed by hydrolysis (H₂O 2h reflux) gave 86% (MeO)₂P(O)CH₂Bu. Phosphonite-borane complexes are introduced as novel synthons for the synthesis of phosphinic esters.

Organic Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Perlikowska, Wieslawa published the artcileLithiation of diethyl trichloromethylphosphonate and the transformations of the α-lithiated derivative, Product Details of C5H10Cl3O3P, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1996), 2611-2613, database is CAplus.

The lithiation of di-Et trichloromethylphosphonate below -100° leads to a stable α-lithiated derivative, but at temperatures of ∼-80° the lithiation is accompanied by spontaneous reactions leading to tetra-Et (chloromethylene)bisphosphonate as the exclusive product. Possible mechanisms of the reaction are discussed. Thus, treating Cl₃CPO₃Et₂ with BuLi and anhydrous LiCl in Et₂O at -105° gave 74% Cl₂CHPO₃Et₂, whereas reaction with BuLi in Et₂O at -80° gave 95% ClCH(PO₃Et₂)₂.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Romdhane, A. published the artcileSynthesis of alkyltrichloromethylphosphonates and their reactivity with some nucleophiles, Application of Diethyltrichloromethylphosphonate, the publication is Journal de la Societe Algerienne de Chimie (2008), 18(1), 55-60, database is CAplus.

The condensation of alkyltrichloromethylphosphonates (RO)₂P(:O)CCl₃ (1: R = Me (a), Et (b)) with primary amine H₂NC₆H₄Me-4, secondary amine HN(C₆H₁₁)₂ and 1,4-binucleophiles 1-HOC₆H₄NH₂-2 and C₆H₄(NH₂)₂-1,2 provides selectively ammonium trichloromethylphosphonate salts [(RO)(Cl₃C)P(:O)O]^–[H₂NR’R”]⁺ (2: R = Me, Et; R’ = C₆H₄Me-4, C₆H₁₁; R” = H, C₆H₁₁) and [(RO)(Cl₃C)P(:O)O]^–[H₃NC₆H₄X]⁺ (3: R = Me, Et; X = OH, NH₂), resp. The structures of all obtained organic compounds where determined by spectroscopic tech. such as IR, NMR (¹H, ¹³C, ³¹P) and in a few cases strengthened by mass spectrometry (FAB⁺).

Journal de la Societe Algerienne de Chimie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lashkhi, V. L. published the artcileMicrocalorimetric study of the adsorption of additives for oils on metal, Computed Properties of 866-23-9, the publication is Neftekhimiya (1974), 14(3), 491-4, database is CAplus.

The adsorption heat, included in some formulas determining the wear, was determined by microcalorimetry, using cyclohexane as carrier liquid and solvent. The higher adsorption heat (≥2) prevailed for Sulfol [[CCl3(CH2)4]2S] [14146-66-8], CCl3(CH2)6P(O)(OEt)2 [53280-04-9], and DF-1 (Ba O,O-dialkyl dithiophosphate) [39360-55-9], while the lower one (≤1) for: MeP(O)(OEt)2 [683-08-9], PhP(O)(OEt2) [1754-49-0], and Zn O,O-diisobutyl O,O-diisooctyl dithiophosphate [54244-07-4]. The antiwear properties of the additives increased with increase of the heat of their adsorption on the metal, according to tests by the frictional machine at low contact loads.

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seyferth, Dietmar published the artcileHalomethyl-metal compounds. LXIII. Diethyl lithiodichloromethylphosphonate and tetraethyl lithiochloromethylenediphosphonate, Safety of Diethyltrichloromethylphosphonate, the publication is Journal of Organometallic Chemistry (1973), 237-45, database is CAplus.

The action of BuLi-THF at low temperature on (EtO)2P(O)CCl3 and (EtO)2P(O)CCl2P(O)(OEt)2 gave LiCCl2P(O)(OEt)2 and [(EtO)2(O)P]2CClLi, resp. Their hydrolysis, coupling reactions with di-Me sulfate, allyl bromide and ClMe3Si and their use in the synthesis of chloroolefins are described.

Journal of Organometallic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C8H13NO3, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garvey, Edward P. published the artcileNucleotide and Nucleoside Analogs as Inhibitors of Cytosolic 5′-Nucleotidase I from Heart, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Biochemistry (1998), 37(25), 9043-9051, database is CAplus and MEDLINE.

Substrate and product specificity studies were used to develop inhibitors of the cytosolic 5′-nucleotidase I (c-N-I) from myocardium. As measured by V_max/K_m, c-N-I preferred pyrimidine 2′-deoxyribonucleotides as substrates with thymidine monophosphate (TMP) being the most efficient. In product inhibition studies, thymidine inhibited noncompetitively and inorganic phosphate inhibited competitively, consistent with an ordered release of nucleoside prior to phosphate. Mirroring nucleotide substrate specificities, pyrimidine nucleosides were more potent product inhibitors than purine nucleosides. Thus, pyrimidine nucleotide and nucleoside analogs were developed as inhibitors. Phosphonate analogs of TMP were synthesized by a novel method. The most potent was the 5′-phosphonate of 3′-deoxythymidine (ddT) (apparent K_i value of 63 nM). In addition, pyrimidine nucleoside analogs were inhibitors with 5-ethynyl-2′,3′-dideoxyuridine being the most potent (apparent K_i value of 3.7 μM). The most potent nucleotide and nucleoside inhibitor were both greater than 1000-fold more potent inhibiting c-N-I than the cytosolic 5′-nucleotidase II. The nucleoside analog was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5′-nucleotidase (e-N). Because the phosphonate analogs measurably inhibited e-N (apparent K_i values of 6-12 μM), the selectivity of the phosphonates for c-N-I vs. e-N was less (40-200-fold). Because of the high selectivity for c-N-I vs. both of the other 5′-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochem. tools in discerning the role that c-N-I plays in generating adenosine within myocardium.

Biochemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sanin, P. I. published the artcileAntiwear additives of phosphonate type, Application of Diethyltrichloromethylphosphonate, the publication is Neftekhimiya (1974), 14(2), 317-22, database is CAplus.

The effectiveness of esters of phosphonic acids depended on their structure and on the friction regime. The esters containing no Cl had no effect at high and low loads. Those containing CCl3 groups were effective at both high and low loads or only at high and only at low ones. The difference was assumed to be due to different chem. and adsorption activity of the compounds and chem. modification of the friction surface. The effectiveness depended on the concentration of additive (1.5-6 mmole/100 g oil).

Neftekhimiya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Arthuis, Martin published the artcilePd⁰-Catalyzed carbonylation of 1,1-dichloro-1-alkenes, a new selective access to Z-α-chloroacrylates, HPLC of Formula: 866-23-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(41), 7810-7812, database is CAplus and MEDLINE.

A novel and fully chemo- and stereoselective three component strategy leading to Z-α-chloroacrylates by a Pd⁰-catalyzed reaction of CO (1 atm) with 1,1-dichloro-1-alkenes and various alcs. is disclosed. This catalytic approach compares favorably with the Wittig type strategies as α-chloroacrylates of pure Z configuration are obtained in high yield.

Chemical Communications (Cambridge, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics