Category: 866763-17-9

Structure-activity relationships of novel potent MurF inhibitors was written by Gu, Yu Gui;Florjancic, Alan S.;Clark, Richard F.;Zhang, Tianyuan;Cooper, Curt S.;Anderson, David D.;Lerner, Claude G.;McCall, J. Owen;Cai, Yingna;Black-Schaefer, Candace L.;Stamper, Geoffrey F.;Hajduk, Philip J.;Beutel, Bruce A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Computed Properties of C7H2Cl3FO3S The following contents are mentioned in the article:

A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC₅₀ = 22 âˆ?70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers. This study involved multiple reactions and reactants, such as 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9Computed Properties of C7H2Cl3FO3S).

2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C7H2Cl3FO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(ii)-NTA probe was written by Uchinomiya, Sho-hei;Nonaka, Hiroshi;Fujishima, Sho-hei;Tsukiji, Shinya;Ojida, Akio;Hamachi, Itaru. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Name: 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride The following contents are mentioned in the article:

A new method for covalent labeling of a His-tag fused protein with a small reactive probe was developed; this method is based on the complementary interaction between the His-tag and Ni(ii)-NTA, which facilitates a nucleophilic reaction between a histidine residue of the tag and the electrophilic tosyl group of the Ni(ii)-NTA probe by the proximity effect. This study involved multiple reactions and reactants, such as 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9Name: 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride).

2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639 was written by Zhang, Qingwei;Xia, Zhiren;Joshi, Shailen;Scott, Victoria E.;Jarvis, Michael F.. And the article was included in ACS Medicinal Chemistry Letters in 2015.Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride The following contents are mentioned in the article:

The discovery of a novel peripherally acting and selective Ca_v3.2 T-type calcium channel blocker, ABT-639 I, is described. HTS hits, which have poor metabolic stability, were optimized to obtain a lead, which has improved stability and oral bioavailability. Modification of the lead to further improve ADME properties led to the discovery of I. Following oral administration, I produces robust antinociceptive activity in exptl. pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. This study involved multiple reactions and reactants, such as 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride).

2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics