Category: 87-63-8

Recently I am researching about ORTHO-ACYLATION; 2H-INDAZOLES; FUNCTIONALIZATION; AZOXYBENZENES; CONDENSATION; AZOBENZENES; ANNULATION; ACCESS; MILD, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21901187, 21672164, 21372177]. Product Details of 87-63-8. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Jin, GQ; Gao, WX; Zhou, YB; Liu, MC; Wu, HY. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline

A straightforward and efficient method for the preparation of 2-aryl-2H-indazoles from ortho-alkyl substituted azoxybenzenes is presented. The reaction proceeds through base-catalyzed benzyl C-H deprotonation and cyclization to afford 2-aryl-2H-indazoles in good yields. This synthetic strategy can be applied to the construction of several fluorescent and bioactive molecules.

Welcome to talk about 87-63-8, If you have any questions, you can contact Jin, GQ; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or send Email.. Product Details of 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Preparation of sub-microspherical Fe3O4@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines WOS:000497443800001 published article about CHEMOSELECTIVE HYDROGENATION; PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; RECYCLABLE CATALYST; REDUCTION in [Guo, Haichang; Zheng, Renhua; Jiang, Huajiang] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China; [Xu, Zhenyuan; Xia, Aibao] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, Zhejiang Key Lab Green Pesticides & Cleaner Prod, Hangzhou 310014, Zhejiang, Peoples R China in 2019, Cited 32. Quality Control of 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Background The side reactions of dehalogenation or C-N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we prepared the sub-microspherical Fe3O4@PDA-Pd NPs catalyst apply it efficiently in the hydrogenation reduction of halogenated aromatic nitro compounds to prepare the halogenated aromatic amines under atmospheric pressure. The catalyst shows a high selectivity of greater than 96% and can effectively inhibit the occurrence of the side reactions of dehalogenation and C-N coupling. Results The optimum condition of the hydroreduction reaction is when tetrahydrofuran is used as solvent and the reaction happens at 50 degrees C for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceed 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling by-products were produced in the brominated aromatic compound and the iodinated aromatic compound. Conclusion We developed a promising method for preparing the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compounds. The halogenated aromatic amines were efficiently and highly selectively prepared under atmospheric pressure, with the side reactions of dehalogenation and C-N coupling effectively inhabited simultaneously.

Quality Control of 2-Chloro-6-methylaniline. Welcome to talk about 87-63-8, If you have any questions, you can contact Guo, HC; Zheng, RH; Jiang, HJ; Xu, ZY; Xia, AB or send Email.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 87-63-8. In 2020 BIOORG CHEM published article about I PI3 KINASE; INHIBITORS; IDENTIFICATION; SAR; THIENOPYRIMIDINE; DISCOVERY in [Ye, Tianyu; Han, Yufei; Wang, Ruxin; Yan, Pingzhen; Chen, Shaowei; Hou, Yunlei; Zhao, Yanfang] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China in 2020, Cited 30. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

To develop novel therapeutic agents with anticancer activities, two series of novel 2,4-bismorpholinyl-thieno [3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives were designed, synthesized and evaluated for their biological activities. Among them, compound A(12) showed the most potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 mu M, 14.37 mu M, 7.39 mu M, 7.10 mu M, and 16.85 mu M, respectively. Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound A(12). The results showed that compound A(12) obviously inhibited the proliferation of A549 cell lines and decreased mitochondrial membrane potential, which led to the apoptosis of cancer cells and suppressed the migration of tumor cells.

Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Preparation of sub-microspherical Fe3O4@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines WOS:000497443800001 published article about CHEMOSELECTIVE HYDROGENATION; PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; RECYCLABLE CATALYST; REDUCTION in [Guo, Haichang; Zheng, Renhua; Jiang, Huajiang] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China; [Xu, Zhenyuan; Xia, Aibao] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, Zhejiang Key Lab Green Pesticides & Cleaner Prod, Hangzhou 310014, Zhejiang, Peoples R China in 2019, Cited 32. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Computed Properties of C7H8ClN

Background The side reactions of dehalogenation or C-N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we prepared the sub-microspherical Fe3O4@PDA-Pd NPs catalyst apply it efficiently in the hydrogenation reduction of halogenated aromatic nitro compounds to prepare the halogenated aromatic amines under atmospheric pressure. The catalyst shows a high selectivity of greater than 96% and can effectively inhibit the occurrence of the side reactions of dehalogenation and C-N coupling. Results The optimum condition of the hydroreduction reaction is when tetrahydrofuran is used as solvent and the reaction happens at 50 degrees C for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceed 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling by-products were produced in the brominated aromatic compound and the iodinated aromatic compound. Conclusion We developed a promising method for preparing the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compounds. The halogenated aromatic amines were efficiently and highly selectively prepared under atmospheric pressure, with the side reactions of dehalogenation and C-N coupling effectively inhabited simultaneously.

Welcome to talk about 87-63-8, If you have any questions, you can contact Guo, HC; Zheng, RH; Jiang, HJ; Xu, ZY; Xia, AB or send Email.. Computed Properties of C7H8ClN

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Biopsy rate and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD) WOS:000542449900001 published article about FIBROSIS; MANAGEMENT; ASSOCIATION; VALIDATION; SYSTEM; SCORE; EASD in [Gerhardt, Florian; Blank, Valentin; Boehlig, Albrecht; van Boemmel, Florian; Berg, Thomas; Karlas, Thomas; Wiegand, Johannes] Univ Hosp Leipzig, Clin & Polyclin Oncol Gastroenterol Hepatol Pneum, Liebigstr 20, D-04103 Leipzig, Germany; [Petroff, David] Univ Leipzig, Clin Trial Ctr Leipzig, Leipzig, Germany; [Blank, Valentin] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany; [Wittekind, Christian] Univ Hosp Leipzig, Inst Pathol, Leipzig, Germany in 2020, Cited 30. Recommanded Product: 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Background:Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require liver biopsy showing fibrosis (F2/3) or cirrhosis (F4) and nonalcoholic steatohepatitis (NASH). However, histological criteria pose a serious obstacle for recruitment. Aims:Characterize the relevance of liver biopsies in the selection of patients with NAFLD. Methods:Patients between 2013 and 2018 with the ICD-10 code K76.0 were analyzed. Fibrosis was defined by the NASH clinical research network (CRN) fibrosis staging system, NASH by a NAFLD activity score (NAS) >= 4. Predictive factors were determined by logistic regression. Results:Liver biopsy was performed in 87/638 (13.6%) patients (49% female, age 52.5 +/- 14.0, BMI 30.4 +/- 5.9 kg/m(2)). Fibrosis stage F0/F1/F2/F3/F4 was observed inN = 7/47/7/17/9, an NAS >= 4 inN = 27. Fibrosis stage F2/F3 and F4 along with NAS >= 4 was found in 1.7% and 0.5% of cases. Liver stiffness measurement, LSM (OR 2.3 per doubling of value; CI 1.3-4.4,p = .005) and FIB-4 (OR 2.3 per doubling of value; CI 1.2-4.4,p = .012) were significant predictors for fibrosis >= F2. Predictive factors for NASH were not identified. Conclusion:The biopsy rate in NAFLD patients is low and fibrosis >= F2 along with NAS >= 4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy.

Recommanded Product: 2-Chloro-6-methylaniline. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Gerhardt, F; Petroff, D; Blank, V; Bohlig, A; van Bommel, F; Wittekind, C; Berg, T; Karlas, T; Wiegand, J in TAYLOR & FRANCIS LTD published article about FIBROSIS; MANAGEMENT; ASSOCIATION; VALIDATION; SYSTEM; SCORE; EASD in [Gerhardt, Florian; Blank, Valentin; Boehlig, Albrecht; van Boemmel, Florian; Berg, Thomas; Karlas, Thomas; Wiegand, Johannes] Univ Hosp Leipzig, Clin & Polyclin Oncol Gastroenterol Hepatol Pneum, Liebigstr 20, D-04103 Leipzig, Germany; [Petroff, David] Univ Leipzig, Clin Trial Ctr Leipzig, Leipzig, Germany; [Blank, Valentin] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany; [Wittekind, Christian] Univ Hosp Leipzig, Inst Pathol, Leipzig, Germany in 2020, Cited 30. Recommanded Product: 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Background:Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require liver biopsy showing fibrosis (F2/3) or cirrhosis (F4) and nonalcoholic steatohepatitis (NASH). However, histological criteria pose a serious obstacle for recruitment. Aims:Characterize the relevance of liver biopsies in the selection of patients with NAFLD. Methods:Patients between 2013 and 2018 with the ICD-10 code K76.0 were analyzed. Fibrosis was defined by the NASH clinical research network (CRN) fibrosis staging system, NASH by a NAFLD activity score (NAS) >= 4. Predictive factors were determined by logistic regression. Results:Liver biopsy was performed in 87/638 (13.6%) patients (49% female, age 52.5 +/- 14.0, BMI 30.4 +/- 5.9 kg/m(2)). Fibrosis stage F0/F1/F2/F3/F4 was observed inN = 7/47/7/17/9, an NAS >= 4 inN = 27. Fibrosis stage F2/F3 and F4 along with NAS >= 4 was found in 1.7% and 0.5% of cases. Liver stiffness measurement, LSM (OR 2.3 per doubling of value; CI 1.3-4.4,p = .005) and FIB-4 (OR 2.3 per doubling of value; CI 1.2-4.4,p = .012) were significant predictors for fibrosis >= F2. Predictive factors for NASH were not identified. Conclusion:The biopsy rate in NAFLD patients is low and fibrosis >= F2 along with NAS >= 4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy.

Recommanded Product: 2-Chloro-6-methylaniline. Welcome to talk about 87-63-8, If you have any questions, you can contact Gerhardt, F; Petroff, D; Blank, V; Bohlig, A; van Bommel, F; Wittekind, C; Berg, T; Karlas, T; Wiegand, J or send Email.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Colomer, I in AMER CHEMICAL SOC published article about HYDROGEN-EXCHANGE; AROMATIC-AMINES; SUBSTITUTED DIALKYLANILINES; ALKYLATION; ACTIVATION; MECHANISM; ACID in [Colomer, Ignacio] Univ Autonoma Madrid, Dept Organ Chem, Madrid 28049, Spain; [Colomer, Ignacio] IMDEA Nanociencia, Madrid 28049, Spain in 2020, Cited 65. Recommanded Product: 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Providing new methods for the selective functionalization of small molecules is highly desirable, because installing molecular diversity in a desired position, for example, allows one to modulate bioactive molecules. This work reports a method for the selective functionalization of anilines using hexafluoroisopropanol (HFIP) as a solvent to promote an acid-catalyzed hydroarylation of olefins. Mechanistic experiments revealed that HFIP both protonates the alkene and selectively enables anilines toward the electrophilic aromatic substitution. This powerful strategy has been applied to the functionalization of the anti-inflammatory mefenamic acid with chemocontrol and regiocontrol.

Recommanded Product: 2-Chloro-6-methylaniline. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H8ClN. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Computed Properties of C7H8ClN. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2020 ORG LETT published article about ARYLATION; ALKYNES; INDOLOQUINOLINES; ACTIVATION; ACCESS; HYDROARYLATION; ANNULATION; ALKALOIDS in [Chen, Chen; Wang, Yuebo; Shi, Xiaonan; Sun, Wan; Zhao, Jinghui; Liu, Liying; Zhu, Bolin] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Peiformance Funct Mol, Tianjin 300387, Peoples R China; [Zhu, Yan-Ping] Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Shandong, Peoples R China in 2020, Cited 56. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Recommanded Product: 2-Chloro-6-methylaniline

Here we report a protocol to synthesize diversiform fluorinated isocryptolepine analogues with potential biological activities in one step via directed C-2 and C-3 dual C-H functionalization of indoles. We also attempted to take into account fluorinated imidoyl chlorides as a novel kind of synthons in the directed C-H functionalization reactions. As a result, a variety of fluorinated isocryptolepine analogues were obtained in up to 96% yield. Moreover, we conducted control experiments to disclose the reaction mechanism.

Recommanded Product: 2-Chloro-6-methylaniline. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry; Crystallography very interesting. Saw the article Synthesis, Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound published in 2020. COA of Formula: C7H8ClN, Reprint Addresses Zhang, P (corresponding author), Shaanxi Univ Chinese Med, Sch Pharm, Xianyang 712046, Shaanxi, Peoples R China.. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline

The heterocyclic compound 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (1), designed using 2-chloro-6-methylaniline (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, and single-cystal X-ray crystallography. To select the suitable candidates for tissue regeneration, the induction activity of the compound on the dental pulp mesenchymal stem cells (DP-MSCs) was evaluated. Firstly, the DP-MSCs cells were isolated and the cell colon formation ability was measured after compound treatment with cell colony determination. After that, the RT-PCT assay was conducted and the relative expression level of the genes related with cell osteogenesis and proliferation was further detected.

COA of Formula: C7H8ClN. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics