Category: 870-24-6

Application of 870-24-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870-24-6, name is 2-Chloroethanamine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-Chloroethanamine hydrochloride (4.6 g, 40 mmol), NEt3 (18 mL, 132 mmol) And 50 mL of methylene chloride. The reaction was stirred at room temperature and trimethylchlorosilane (90 mmol, 9.8 g, 11.4 mL) in dichloromethane (20 mL) was added to the system. The reaction was stirred at room temperature overnight. After the reaction was completed, excess triethylamine, trimethylchlorosilane and methylene chloride were removed under reduced pressure. To the resulting residue was added 60 mL of n-hexane. The reaction was stirred at room temperature for 30 minutes and filtered to remove NEt3.HCl. After the filtrate is concentrated, The target product was obtained by distillation under reduced pressure (6.0 g, 68%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloroethanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tsinghua University; Liu Qiang; Fu Shaomin; Shao Zhihui; Wang Yujie; (20 pag.)CN107445995; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870-24-6, name is 2-Chloroethanamine hydrochloride, A new synthetic method of this compound is introduced below., name: 2-Chloroethanamine hydrochloride

In a first reaction step, 3-chloroethylamine hydrochloride (73.86 g, 0.70 mol, 1.00 eq) is initially charged in ethanol (3.0 l) in a 4 l three-neck flask with precision glass stirrer, internal thermometer, dropping funnel and reflux condenser, and cooled to -78 C., and sodium ethoxide (226.83 g, 0.70 mol, 1.00 eq, 21% in ethanol) is added. 3-Isocyanatopropyl(triethoxysilane) (173.15 g, 0.70 mol, 1.00 eq) is then added dropwise at -78 to -70 C. within 3 h and then the mixture is heated to 50 C. Dry sodium sulphide (Na2S, 27.31 g, 0.35 mol, 0.50 eq) is added in five portions and the mixture is heated to reflux. After a reaction time of 4 h, the mixture is cooled to room temperature and the suspension is filtered. The filtrate is freed of the solvent on a rotary evaporator and dried under reduced pressure. The (EtO)3Si-CH2CH2CH2-NH-CO-NH-CH2CH2-S-CH2CH2-NH-CO-NH-CH2CH2CH2-Si(OEt)3 product (212.68 g, 98.8% of theory) is obtained as a yellow oil.

The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Evonik Industries AG; Moser, Ralph; Mayer, Stefanie; (10 pag.)US2015/329571; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 870-24-6, The chemical industry reduces the impact on the environment during synthesis 870-24-6, name is 2-Chloroethanamine hydrochloride, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of the corresponding pyrrole or indole derivative (10 mmol) in MeCN (30 ml) was added sodium hydroxide (2.00 g, 50 mmol) and tetrabutylamonium hydrogen sulfate (0.17 g, 0.5 mmol). After the solution was stirred at room temperature for 30 min, 2-chloroethylamine hydrochloride (1.39 g, 12 mmol) was added. Then the reaction mixture was refluxed for 24 h. The mixture was poured into water (100 ml), extracted with diethyl ether, dried under MgSO4, and concentrated under reduced pressure to give a crude product. The crude was then purified by flash column chromatography on silica gel (eluted with petroleum ether / ethyl acetate=1 : 1) to give the pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloroethanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tian, Yu-Ting; Zong, Yu-Wei; Nie, Jing; Zhang, Fa-Guang; Ma, Jun-An; Journal of Fluorine Chemistry; vol. 226; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 870-24-6, A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. In a 500 ml four-necked flask equipped with magnetic stirring, 20.0 g of beta-mercaptoethanol and 1.0 g of Fe-EG catalyst were added, and 50 ml of a newly prepared 30% strength NaOH solution was added dropwise at room temperature.After 15 minutes of dropwise addition, the temperature was raised to 50 C, and 30.0 g of 2-chloroethylamine hydrochloride was dissolved in 17.3 ml of water.Slowly drip into the above reaction bottle, 1h drop addition, continue to keep warm at 50 C and stir for 0.5h;Step 2, after the reaction, the solution is light yellow transparent, a small amount of white solid precipitates at the bottom, the system pH=10, the upper clear liquid is dried at 50 C to obtain a beige viscous liquid, the product is dissolved with absolute ethanol, filtered, and the filtrate is decompressed. Distillation gave the pale yellow viscous liquid product 2-amino-2-hydroxy-diethyl sulfide.

The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fuzhou Huabolile New Materials Technology Co., Ltd.; Mei Dandan; Yang Guilian; (7 pag.)CN108373432; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870-24-6, name is 2-Chloroethanamine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 870-24-6

In a 500 ml four-necked flask,343 parts of dimethylformamide,31.6 parts of triethylamine and 2-chloroethylamine hydrochloride(Manufactured by Tokyo Chemical Industry Co., Ltd.) 33.2 parts, and the mixture was stirred for 10 minutes. 49.6 parts of p-toluenesulfonyl chloride (manufactured by Tokyo Chemical Industry Co., Ltd.)Was added little by little so that the liquid temperature did not exceed 20 C.,And the mixture was stirred at room temperature for 3 hours.The reaction solution was poured into cooled 5% aqueous hydrochloric acid,After stirring for 15 minutes, the precipitated crystals were collected by filtration, washed,By drying,33.8 parts of a dye intermediate represented by the following formula (101) was obtained.

The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; SUZUKI, SAORI; MORITA, RYOUTARO; (29 pag.)JP2018/53152; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870-24-6, name is 2-Chloroethanamine hydrochloride, A new synthetic method of this compound is introduced below., Formula: C2H7Cl2N

Step-I: 2-(2-Methyl-1H-pyrrol-1-yl)ethanamineSodium hydroxide anhydrous (9.87 g, 0.246 mol, 4.0 eq.) and TBAHS (0.838 g, 0.002 mol, 0.04 eq.) were added to a solution of 2-methyl-1 H-pyrrole (5.0 g, 0.061 mol, 1.0 eq.) in acetonitrile (180 ml) at 0 C and the mixture was stirred at RT for 1 h. 2-Chloroethylamine hydrochloride (8.59 g, 0.074 mol, 1.2 eq.) was added to the reaction mixture and it was then heated at reflux for 16 h. The reaction mixture was cooled to RT, filtered through celite and washed with 10% MeOH/DCM (200 ml). The filtrate was concentrated under reduced pressure to give the crude product which was used in the next step without further purification.Yield: 100 %, crude (7.6 g, 0.061 mol)

The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GRUeNENTHAL GMBH; REICH, Melanie; SCHUNK, Stefan; OBERBOeRSCH, Stefan; JOSTOCK, Ruth; GERMANN, Tieno; ENGELS, Michael; WO2012/28331; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 870-24-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 870-24-6, name is 2-Chloroethanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

13.5 g of 2-chloroethylamine hydrochloride was added to 8.7 g of mercaptoethanol solution under stirring, adjusted to pH=4.8, and reacted at 55 C. for 4 hours to produce 13.2 g.beta-2-aminoethylmercaptoethan-1-ol. Cooling to 0C,Slowly add 59g (40%) of tidal acetaminophenone chloride, adjust pH=3.8, control temperature at 0-2C for 4 hours, separate,Washing afforded 30.7 g of p-acetamidobenzenesulfonamide ethyl-2-hydroxyethyl sulfide

The chemical industry reduces the impact on the environment during synthesis 2-Chloroethanamine hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Taixing Jinyun Dyeing Liao Co., Ltd.; Zhao Weiguo; Su Jinqi; Ju Suhua; Wang Guomin; Zhang Weiping; (27 pag.)CN104592786; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 870-24-6,Some common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzenesulfonyl chloride(525 mg, * 380 lL, 3 mmoL) was gradually added to a50-mL round-bottom flask containing 2-chloroethylamine.HCl (116 mg, 3 mmol) in dimethyl formamide(5 mL) and triethylamine (TEA, 500 lL). The reaction mixture was stirred at room temperature for 3 h and then poured into a cold solution of HCl 5 % (50 mL). The precipitate was collected and dried under vacuum at 40C to give compound 2a, which was used for the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloroethanamine hydrochloride, its application will become more common.

Reference:
Article; Thuan, Nguyen Thi; Dung, Do Thi Mai; Que, Do Nguyet; Dung, Phan Thi Phuong; Vu, Tran Khac; Hahn, Hyunggu; Han, Byung Woo; Kim, Youngsoo; Han, Sang-Bae; Nam, Nguyen-Hai; Medicinal Chemistry Research; vol. 24; 11; (2015); p. 3803 – 3812;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 870-24-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 870-24-6, Name is 2-Chloroethanamine hydrochloride, SMILES is ClCCN.[H]Cl, belongs to chlorides-buliding-blocks compound. In a article, author is Chen, Yao, introduce new discover of the category.

Cationic polyacrylamide (CPAM) contains a large number of acylamino and positively charged methyl ammonium chloride groups. It has the advantages of good water solubility, strong adsorption bridging ability, enhanced charge neutralization and destabilization performance, excellent flocculation effect, and wide application. Therefore, CPAM can be used in the treatment of coal washing wastewater, and the research and development of a new flocculant with high efficiency is a hot topic in this field. Template copolymer (TPADM) of methacryloyloxyethyl trimethyl ammonium chloride (DMC) and acrylamide (AM) was synthesized by microwave-template initiated polymerization with sodium polyacrylate (PAAS) as template. The microwave-template initiated polymerization is abbreviated as MW-TP. By analyzing FTIR,H-1 (C-13) NMR and TG/DSC of TPADM, it was found that TPADM had obvious cationic fragment structure. In addition, the association constant (K-M) and the kinetics of the template reaction showed that the MW-TP was confirmed to be free radical initiated polymerization and I Zip-up (ZIP) polymerization mechanism, which demonstrated the formation of the cationic fragment structure again. This new cationic fragment structure greatly enhanced the ability of charge neutralization, electrical patching and adsorption bridging, thus improving the flocculation performance. Compared with cationic P(AM-DMC) (CPADM), Commercial cationic polypropanamide (CCPAM-1 and CCPAM-2), TPADM had better flocculation effect on coal washing wastewater. Under the optimum flocculation conditions (dosage = 16 mg/L, pH = 7.5), suspended solid (SS) concentration and turbidity of coal washing wastewater treated by TPADM reached 14.3 mg/L and 8.7 NTU, respectively. The floc formation, breakage, and regeneration analyses showed that the cationic fragment structure in TPADM could contribute to the formation of large and high density flocculation structure (d(50) >= 245 mu m,D-f >= 2.05), and these coal flocs can regenerate rapidly after being broken. Finally, these large and compact flocs help to accelerate the flocs sedimentation and reduce the SS concentration and turbidity of coal washing wastewater, and enhance the effect of solid-liquid separation.

Electric Literature of 870-24-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 870-24-6.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 870-24-6, Name is 2-Chloroethanamine hydrochloride, SMILES is ClCCN.[H]Cl, in an article , author is Chen, Lei, once mentioned of 870-24-6, Name: 2-Chloroethanamine hydrochloride.

The aim of the present study was to investigate the role of platelet-derived growth factor (PDGF)-BB/PDGF receptor (R)-beta signaling in an experimental murine corneal neovascularization (CrNV) model. Experimental CrNV was induced by alkali injury. The intra-corneal expression of PDGF-BB was examined using immunohistochemistry. The effect of PDGF-BB on CrNV was evaluated using immunofluorescence staining. The expression levels of PDGFR-beta in human retinal endothelial cells (HRECs) under normal conditions or following cobalt chloride treatment, which induced hypoxic conditions, was assessed using reverse transcription-quantitative PCR. The effect of exogenous treatment of PDGF-BB on the proliferation, migration and tube formation of HRECs under normoxic or hypoxic conditions was evaluated in vitro using Cell Counting Kit-8, wound healing and 3D Matrigel capillary tube formation assays, respectively. The results indicated that the intra-corneal expression levels of the proteins of PDGF-BB and PDGFR-beta were detectable on days 2 and 7 following alkali injury. The treatment with neutralizing anti-PDGF-BB antibody resulted in significant inhibition of CrNV. The intra-corneal expression levels of vascular endothelial growth factor A, matrix metallopeptidase (MMP)-2 and MMP-9 proteins were downregulated, while the expression levels of thrombospondin (TSP)-1, TSP-2, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 and ADAMTS-2 were upregulated significantly in mice treated with anti-PDGF-BB antibody. The expression levels of PDGFR-beta were upregulated in HRECs under hypoxic conditions compared with those noted under normoxic conditions. Recombinant human PDGF-BB promoted the proliferation, migration and tube formation of HRECs under hypoxic conditions. The data indicated that PDGF-BB/PDGFR-beta signaling was involved in CrNV and that it promoted endothelial cell proliferation, migration and tube formation. The pro-angiogenic effects of this pathway may be mediated via the induction of pro-angiogenic cytokine secretion and the suppression of anti-angiogenic cytokine secretion.

Interested yet? Read on for other articles about 870-24-6, you can contact me at any time and look forward to more communication. Name: 2-Chloroethanamine hydrochloride.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics