Category: 870-24-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 870-24-6, name is 2-Chloroethanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Formula: C2H7Cl2N

In a IL round bottom flask, 50.4g sodium hydroxide (1.26mol) was dissolved in 50OmL water (-10% solution). 66.6g (.574mol) 2-chloroethylamine hydrochloride was then added and the solution stirred in an ice bath at 0C until the salt was completely dissolved. lOOg (.631mol) 4-fluorobenzoyl chloride was then added dropwise via an addition funnel into the vigorously stirred solution. After addition, the solution stirred at O0C for 1 hour followed by stirring at room temperature for 1 hour. The cloudy mixture was then filtered to remove the water and the solids washed with ether and then filtered to give ~118g crude (slightly wet) benzamide (Alternatively, the solids could be dissolved in methylene chloride, dried with magnesium sulfate, filtered and evaporated to completely remove water from the solids). These solids were recrystallized from 120ml EtOAc/200mL hexanes to give 88.2g crystalline N-(2-chloroethyl)-4-fluorobenzamide after hexanes wash and drying (an additional 6.22g benzamide recrystallized from the original water mother liquor). NMR confirmed the structure of this compound (81.4% total yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 870-24-6.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; WO2006/121811; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 870-24-6, A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(4-Methoxyphenylthio)ethanamine (1) 4-Methoxythiophenol (50 g, 0.357 mol), 2-chloroethylamine monohydrochloride (39.8 g, 0.343 mol.), K2CO3( 78.8 g, 0.57 mol) and diisopropyl ethylamine (32 mL, 0.178 mol) were mixed in 200 mL of THF. The mixture was degassed for 5 min. under reduced pressure and refluxed under argon overnight. The solvent was removed and water (300 mL) was added to the flask. The mixture was extracted with dichloromethane (3 x 200 mL). The organics were collected, dichloromethane was removed and 50 mL conc. HCl was added, followed by 200 mL of water. The solution was extracted with 1:1 EtOAc/hexane (3 x 200 mL). The aqueous layer was adjusted to pH 10 with 2 M NaOH, and was extracted with dichloromethane (3 x 200 mL). The combined organic solution was dried over anhydrous sodium sulfate. Removal of solvent provided 61 g of the target compound as a colorless liquid, with a yield of 97%. 1H-NMR (300 MHz, CDCl3): 7.35(d, J = 8.7 Hz, 2H), 6.81 (d, J= 8.7 Hz, 2H), 3.77 (s, 3H), 2.88-2.80 (m, 4H), 1.44 (s, 2H).

The synthetic route of 870-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Les Laboratoires Servier; Armgo Pharma, Inc.; Yan, Jiaming; Belvedere, Sandro; Webb, Yael; Bertrand, Marc; Villeneuve, Nicole; EP2653466; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 870-24-6.

Preparation of 2-aminoethylazide 2-chloroethylamine hydrochlorate (Sigma Aldrich) is solubilized in water (133 g/L) at 80 C. Then sodium azide (3 eq., Sigma Aldrich) is added and the mixture is kept under reflux and magnetic stirring for the night. The mixture is cooled to room temperature then to 0 C. using an ice bath. Potassium hydroxide (same amount as 2-chloroethylamine hydrochlorate, Prolabo) is added and after total dissolution, the product is extracted using diethyl ether. Organic phase is dried over magnesium sulfate (Acros Organics), filtered and finally evaporated to obtain 2-aminoethylazide (20 mol.% yield).

The synthetic route of 2-Chloroethanamine hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITE DE BORDEAUX; Centre national de la recherche scientifique; INSTITUT DES CORPS GRAS ETUDES ET RECHERCHES TECHNIQUES-ITERG; INSTITUT POLYTECHNIQUE DE BORDEAUX; Institut Technologique FCBA; CRAMAIL, Henri; GRELIER, Jean-Pierre Albert Stephane; PICHAVANT, Frederique; DA SILVA PEREZ, Denilson; ALFOS, Carine; CHEMIN, Suzanne Maud; (16 pag.)US2018/2453; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics