Category: 886615-30-1

Scheuermann, Thomas H. published the artcileIsoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde, the main research area is hypoxia inducible factor inhibitor preparation.

Hypoxia inducible factor (HIF) transcription factors reside at the center of signaling pathways used by mammalian cells to sense and respond to low oxygen levels. While essential to maintain oxygen homeostasis, misregulation of HIF protein activity correlates with tumor development and metastasis. To provide artificial routes to target misregulated HIF activity, the authors identified small mol. antagonists of the HIF-2 transcription factor that bind an internal cavity within the C-terminal PAS domain of the HIF-2α subunit. Here the authors describe a new class of chiral small mol. ligands that provide the highest affinity binding, the most effective, isoform-selective inhibition of HIF-2 in cells, and trigger the largest protein conformation changes reported to date. The current results further illuminate the mol. mechanism of HIF-2 antagonism and suggest addnl. routes to develop higher affinity and potency HIF-2 antagonists.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bester, Stephanie M. published the artcileStructural and mechanistic bases for a potent HIV-1 capsid inhibitor, Application of 3-Bromo-6-chloro-2-fluorobenzaldehyde, the main research area is GS 6207 preparation antiviral HIV1 capsid inhibitor.

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby preventing functional disassembly of the capsid shell in infected cells. X-ray crystallog., cryo-electron microscopy, and hydrogen-deuterium exchange experiments revealed that GS-6207 tightly binds two adjoining capsid subunits and promotes distal intra- and inter-hexamer interactions that stabilize the curved capsid lattice. In addition, GS-6207 interferes with capsid binding to the cellular HIV-1 cofactors Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich regions of chromatin. These findings elucidate structural insights into the multimodal, potent antiviral activity of GS-6207 and provide a means for rationally developing second-generation therapies.

Science (Washington, DC, United States) published new progress about Anti-HIV agents (anti-HIV-1 agents). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Application of 3-Bromo-6-chloro-2-fluorobenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Toyota, Kozo published the artcileUnexpected formation of 4,7-dihalobenzo[b]thiophenes using Ohira-Bestmann reagent and reactivity of the halogen-substituted benzo[b]thiophenes in Suzuki-Miyaura coupling with phenylboronic acid, HPLC of Formula: 886615-30-1, the main research area is phenyl halobenzothiophene preparation regioselective; phenylboronic acid dihalobenzothiophene Suzuki coupling palladium catalyst.

Reaction of 2-(1-adamantylsulfanyl)-3,6-dihalobenzaldehydes 2-X-5-Y-6-SR1C6H2CHO (X = Br, I, Cl, H, Ph; Y = Br, I, Cl, H; R1 = adamantan-1-yl) with Ohira-Bestmann reagent gave 4,7-dihalobenzo[b]thiophenes I along with normal alkyne products 2-X-5-Y-6-SR1C6H2CC . Nine types of 4,7-dihalobenzo[b]thiophenes I bearing chlorine, bromine, or iodine atoms, were prepared by this method. Regioselectivity in Suzuki-Miyaura cross coupling reactions of the 4,7-dihalobenzo[b]thiophenes I with PhB(OH)2 was also studied.

Heterocycles published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, HPLC of Formula: 886615-30-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mikami, Shinichi published the artcileSilica gel-assisted preparation of 2,4,7-trihalobenzo[b]thiophenes and 4,7-dihalobenzo[b]thiophenes, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde, the main research area is halobenzothiophene preparation.

All 6 isomers of (bromo)(chloro)(iodo)benzo[b]thiophenes containing three different halogen atoms at the 2-, 4- and 7-positions I (X = I, Br, Cl; Y = I, Br, Cl; Z = I, Br, Cl) were synthesized from the corresponding 2-(1-adamantylsulfanyl)-1,4-dihalo-3-(haloethynyl)benzene derivatives 2-RS-3-ZCC-4-XC6H2Y (R = adamantan-1-yl), through treatment with silica gel under thermal conditions. In contrast to the previous method using gold chloride catalyst, migration of adamantyl group did not occur in this method using silica gel. Moreover, by using this method, 6 types of 4,7-dihalobenzo[b]thiophenes I (Z = H) have been synthesized in 4 steps from 2-fluoro-3,6-dihalo-benzaldehydes 2-F-3Y-6-XC6H2CHO in moderate to excellent overall yields (42-82%).

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mikami, Shinichi published the artcileSilica gel-assisted preparation of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions, Product Details of C7H3BrClFO, the main research area is benzothiophene dihalo trihalo preparation stereoselective silica gel; sulfide adamantyl alkynylaryl halo preparation intramol cyclization silica.

Six types of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions were prepared from the corresponding 2-(1-adamantylthio)-1,4-dihalo-3-(haloethynyl)benzene derivatives, by treatment with silica gel under thermal conditions. 4,7-Dihalobenzo[b]thiophenes, bearing two different halogen atoms (chlorine, bromine, or iodine), were also prepared from 2-(1-adamantylthio)-3-(ethynyl)-1,4-dihalobenzenes.

Heterocycles published new progress about Aldehydes, halo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Product Details of C7H3BrClFO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics