Category: 89-77-0

On May 15, 2022, Liu, Jingbo; Shi, Yabing; Chen, Shuting; Li, Fengyun; Wen, Wen; Wang, Yuanhong published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Discovery of evodiamine derivatives as potent insecticide candidates. And the article contained the following:

In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, resp.), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a pos. influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to evodiamine derivative mythimna plutella helicoverpa larvicide, evodiamine, insecticidal activity, mode of action, structure activity relationships, Placeholder for records without volume info and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 31, 2022, Liu, Tingting; Peng, Feng; Zhu, Yunying; Cao, Xiao; Wang, Qifan; Liu, Fang; Liu, Liwei; Xue, Wei published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Design, synthesis, biological activity evaluation and mechanism of action of myricetin derivatives containing thioether quinazolinone. And the article contained the following:

Plant bacteria and viruses have a huge neg. impact on food crops in the world. Therefore, it is important to create new and efficient green pesticides. In this paper, a series of myricetin derivatives containing quinazolinone sulfide were introduced. Good antibacterial and antiviral activities of the drug mols. 2-((3-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)propyl)thio)-6-fluoro-3-phenylquinazolin-4(3H)-one (T5) and 2-((4-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)butyl)thio)-6-methyl-3-phenylquinazolin-4(3H)-one (T15) resp. were found by biol. activity screening. The value of dissociation constant (Kd) of compound T15 to TMV CP was 0.024 ± 0.006 μM, determined by Microscale thermophoresis (MST), which was far less than the value of 8.491 ± 2.027 μM of com. drug ningnanmycin (NNM). The interaction between compound T15 and TMV CP was further verified by mol. docking. Compound T15 formed strong hydrogen bonds with residues SER:49 and SER:15 (1.92 Å, 2.20 Å, resp.), which were superior to the traditional hydrogen bonds formed by NNM with residue SER:215 (3.64 Å). In addition, the effects of compound T15 on the contents of chlorophyll and peroxidase (POD) in tobacco were studied, and the results indicated that compound T15 could enhance the disease resistance of tobacco plants to a certain extent. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to thioether quinazolinone myricetin derivative mechanism antibacterial antiviral pesticide, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 11, 2022, Chen, Jinglei; Hu, Hang; Ye, Kai; Wang, Wei; Xu, Defeng published an article.Reference of 2-Amino-4-chlorobenzoic acid The title of the article was Synthesis of Novel Pyrimidinylselenium Compounds as Acetolactate Synthase-Inhibiting Herbicides. And the article contained the following:

A series of pyrimidinylselenosalicylic acid derivatives (5 a-5 l) and 4-selenopyrimidine derivatives (6 a-6 f) were synthesized and evaluated as potential acetylactate synthase (ALS)-inhibiting herbicides. All synthesized new compounds were characterized by 1H NMR, 13C NMR, and high-resolution mass spectrometry (HRMS). The compounds were subjected to herbicidal activity, in vitro ALS enzyme inhibitory activity, and crop safety studies. The herbicidal activity study shows that 4-chloro (5 b), 5-chloro (5 c), 5-methoxy (5 e), 4,5-dimethoxy (5 f), 5-fluoro (5 h), and 4,5-difluoro (5 i) substituted 2-[(4,6-dimethoxy-2-pyrimidinyl)selanyl]benzoic acid exhibit significantly enhanced weed control effect than other new compounds and Pyrithiobac. Most of compounds exhibit enhanced inhibition effect on Cyperus difformis Linn than those on barnyard grass, Portulaca oleracea, Eleusine indica, and Amaranthus retroflexus. Importantly, 5 c, 5 f, and 5 i also exhibit more potent inhibition effect on Escherichia coli ALS enzyme than other new compounds and Pyrithiobac in in vitro ALS enzyme inhibitory activity study. The possible binding modes of 5 c, 5 f, and 5 i with ALS enzyme were studied on Discovery Studio. To test the possibility of 5 c, 5 f, and 5 i as potential herbicides in paddy fields, we performed the crop safety study. The results show that 5 f and 5 i are safer to rice than 5 c. The present work indicates that 5 f and 5 i may serve as new herbicide candidates for weed control in paddy fields. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to eleusine amaranthus portulaca pyrimidinylselenium acetolactate synthase herbicide, Placeholder for records without volume info and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fisch, Alexander; Reiber, Chelsea; Schroeder, William; Smart, Robert; Patel, Osman V. published an article in 2020, the title of the article was Potent suppression of proliferation of breast carcinoma cells by a novel anthranilic acid derivative.Formula: C7H6ClNO2 And the article contains the following content:

Chemotherapy remains the mainstay therapy for the most intrusive-type of breast carcinoma, triple-neg. breast cancer (TNBC) that has a higher tendency for visceral metastases, relapses, and poor prognoses. It is well recognized that the reactivation of a ribonucleoprotein enzyme, telomerase is among the key determinants of breast carcinogenesis, cellular immortalization and metastatic progression. Therefore, our objectives were to assess (i) short- and (ii) long-term effects of a novel anthranilic acid (GV6) developed at our institute and compare it to a known analog, BIBR1532 on TNBC (MDA-MB 231) and non-TNBC (MCF-7) cells. Seeded TNBC and non-TNBC flasks were supplemented with 25 μM of either BIBR 1532 or GV6 or solvent (DMSO) alone for 14 (Short-term) or 27 (Longterm) days. Trypan-blue dye exclusion test was utilized to determine viable cells, senescence-associated β-galactosidase activity was employed to detect senescent cells and qPCR was used to quantitate transcript abundance. Cell viability assay revealed that short- and longterm growth inhibitions of TNBC and non-TNBC cells were comparable between BIBR1532 and GV6. Cytochem. detection of β-Galactosidase demonstrated that GV6 was equally effective in inducing replicative senescence in treated TNBC and non-TNBC cells. Short- and long-term regimen of BIBR1532 and GV6 showed similar druginduced downregulation of hTERT in TNBC and non-TNBC cells. Results indicate that GV6 is an equally potent inhibitor of hTERT that induces growth impedance and triggers senescence in TNBC, as well as non-TNBC cells and merits further studies for improved treatment options. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to cell proliferation breast carcinoma anthranilic acid derivative drug development, Placeholder for records without volume info and other aspects.Formula: C7H6ClNO2

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2021, Zhang, Zixue; Zhang, Qingwei; Zhang, Hao; Jiao, Minru; Guo, Zheng; Peng, Xinyan; Fu, Lei; Li, Jianqi published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities. And the article contained the following:

A series of quinazolinyl-containing benzamide derivatives were designed, synthesized and evaluated for their in vitro histone deacetylase 1 (HDAC1) inhibitory activities. Compounds 11a surpassed the known class I selective HDAC inhibitor MS-275 in both HDAC1 enzymic inhibitory activity and cellular anti-proliferative activity against a selected set of cancer cell types (Hut78, K562, Hep3B and HCT116 cells) with no observed effects on human normal cells. In particular, compound 11a inhibited HDAC1 over the other tested HDACs isoforms (HDAC2, HDAC6 and HDAC8) with acceptable safety profiles. Moreover, compound 11a displayed favorable oral pharmacokinetic properties and showed significant antitumor activity in the A549 tumor xenograft model in vivo. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid

The Article related to lung cancer hdac1 inhibitors quinazolinyl benzamide derivative, anti-proliferative activity, histone deacetylases, quinazolinyl, selectivity, tumor growth inhibition, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 2, 2020, Manna, Kartic; Begam, Hasina Mamataj; Samanta, Krishanu; Jana, Ranjan published an article.Related Products of 89-77-0 The title of the article was Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids. And the article contained the following:

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramol. allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramol. carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to palladium catalyst chemoselective regioselective stereoselective allylic oxidation allyl ether, deallylation stereoselective allylic oxidation allyl ether, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2021, Panagopoulos, Anastasios; Balalas, Thomas; Mitrakas, Achilleas; Vrazas, Vassilios; Katsani, Katerina R.; Koumbis, Alexandros E.; Koukourakis, Michael I.; Litinas, Konstantinos E.; Fylaktakidou, Konstantina C. published an article.Product Details of 89-77-0 The title of the article was The 6-Nitro-Quinazolin-4(3H)-one Exhibits Photodynamic Effects and Photodegrades Human Melanoma Cell Lines. A Study on the Photoreactivity of Simple Quinazolin-4(3H)-ones. And the article contained the following:

Photochemo and photodynamic therapies are minimally invasive approaches for the treatment of cancers and powerful weapons for competing bacterial resistance to antibiotics. Synthetic and naturally occurring quinazolinones are considered privileged anticancer and antibacterial agents, with several of them to have emerged as com. available drugs. In the present study, applying a single-step green microwave irradiation mediated protocol we have synthesized eleven quinazolinon-4(3H)-ones, from cheap readily available anthranilic acids, in very good yields and purity. These products were irradiated in the presence of pBR322 plasmid DNA under UVB, UVA and visible light. Four of the compounds proved to be very effective DNA photocleavers, at low concentrations, being time and concentration dependent as well as pH independent. Participation of reactive oxygen species was related to the substitution of quinazolinone derivatives 6-Nitro-quinazolinone in combination with UVA irradiation was found to be in vitro photodestructive for three cell lines; glioblastoma (U87MG and T98G) and mainly melanoma (A-375). Thus, certain appropriately substituted quinazolinones may serve as new lead photosensitizers for the development of promising biotechnol. applications and as novel photochemo and photodynamic therapeutics. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to nitroquinazolin photodynamic photodegrade photoreactivity melanoma, Biochemical Methods: Spectral and Related Methods and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 29, 2020, Shafie, Arefeh; Mohammadi-Khanaposhtani, Maryam; Asadi, Mehdi; Rahimi, Nastaran; Ranjbar, Parviz Rashidi; Ghasemi, Jahan B.; Larijani, Bagher; Mahdavi, Mohammad; Shafaroodi, Hamed; Dehpour, Ahmad Reza published an article.Synthetic Route of 89-77-0 The title of the article was Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations. And the article contained the following:

A novel series of 1,2,3-triazolo-benzodiazepine derivatives 6a-o has been synthesized and evaluated in vivo for their anticonvulsant activities using by pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizures in mice. The synthetic approach started with diazotizing 2-aminobenzoic acids 1 to produce 2-azidobenzoic acids 2. Next, reaction of the latter compounds with propargylamine 3, benzaldehyde 4, and isocyanides 5 led to the formation of the title compounds 6a-o, in good yields. All the synthesized compounds exhibited high anticonvulsant activity in the PTZ test, comparable to or better than the standard drug diazepam. Among the tested compounds, N-(tert-butyl)-2-(9-chloro-6-oxo-4H-[1,2,3]triazolo[1,5-a][1,4]benzodiazepin-5(6H)-yl)-2-(3-bromophenyl)acetamide 6h was the most potent compound in this assay. Moreover, compounds 6i and 6k showed excellent activity in MES test. Loss of the anticonvulsant effect of compound 6h in the presence of flumazenil in the PTZ test and appropriate interaction of this compound in the active site of benzodiazepine (BZD)-binding site of GABAA receptor confirm involvement of BZD receptors in the anticonvulsant activity of compound 6h. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to triazolo benzodiazepine anticonvulsant agent seizure, 1,2,3-triazolo-benzodiazepine, anticonvulsant, docking study, seizure, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Synthetic Route of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 8, 2020, Han, Sheng; Sang, Yali; Wu, Yan; Tao, Yuan; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fen-Er published an article.Product Details of 89-77-0 The title of the article was Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles. And the article contained the following:

Mol. hybridization is a powerful strategy in drug discovery. A series of novel diarylbenzopyrimidine (DABP) analogs were developed by the hybridization of FDA-approved drugs etravirine (ETR) and efavirenz (EFV) as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). Substituent modifications resulted in the identification of new DABPs with the combination of the strengths of the two drugs, especially compound 12d, which showed promising activity toward the EFV-resistant K103N mutant. 12d also had a favorable pharmacokinetic (PK) profile with liver microsome clearances of 14.4μL/min/mg (human) and 33.2μL/min/mg (rat) and an oral bioavailability of 15.5% in rat. However, its activity against the E138K mutant was still unsatisfactory; E138K is the most prevalent NNRTI resistance-associated mutant in ETR treatment. Further optimizations resulted in a highly potent compound (12z) with no substituents on the Ph ring and a 2-methyl-6-nitro substitution pattern on the 4-cyanovinyl-2,6-disubstituted Ph motif. The antiviral activity of this compound was much higher than those of ETR and EFV against the WT, E138K, and K103N variants (EC50 = 3.4, 4.3, and 3.6 nM, resp.), and the cytotoxicity was decreased while the selectivity index (SI) was increased. In particular, this compound exhibited acceptable intrinsic liver microsome stability (human, 34.5μL/min/mg; rat, 33.2μL/min/mg) and maintained the good PK profile of its parent compound EFV and showed an oral bioavailability of 16.5% in rat. Mol. docking and structure-activity relationship (SAR) anal. provided further insights into the binding of the DABPs with HIV-1 reverse transcriptase and provided a deeper understanding of the key structural features responsible for their interactions. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to mol hybridization diarylbenzopyrimidine hiv1 reverse transcriptase nnrti pk, hiv-1, nnrti, pk, diarylbenzopyrimidines, molecular hybridization, reverse transcriptase, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 30, 2021, Chen, Dong; Li, Shiqing; Wang, Jinhua; Gou, Tiantian; Zhang, Linfeng; Wang, Guixia; Kong, Xiangfei published an article.Safety of 2-Amino-4-chlorobenzoic acid The title of the article was Visible-Light-Mediated Synthesis of Rutaecarpine Alkaloids through C-N Cross-Coupling Reaction. And the article contained the following:

A visible-light-initiated cross-dehydrogenative-coupling amination is described, featuring metal- and photocatalyst-free, at room temperature, and using air as an oxidant. The reaction provides a facile approach for the synthesis of rutaecarpine and its derivatives The substrates with electron-withdrawing groups give higher yields than those with electron-donating groups, but the substituent position has a negligible influence on the yield. Using binaphthyl-diyl hydrogen phosphate and dibenzyl phosphate as catalysts both deliver satisfying yields. This straightforward light-driven strategy might be applicable to the synthesis of quinazolinone derivatives The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Safety of 2-Amino-4-chlorobenzoic acid

The Article related to aniline benzamide cross dehydrogenation coupling amination oxidation photocatalyst light, quinazolinone alkaloid preparation, rutaecarpine preparation, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Safety of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics