Category: 89-77-0

He, Yuan-Yuan; Zhu, Mei-Shan; Gao, Yang; Hu, Xiao-Qiang published an article in 2022, the title of the article was Access to quinolinones via DMAP-catalysed cascade reaction of 2-substituted benzoic acids with organic azides.Recommanded Product: 89-77-0 And the article contains the following content:

A DMAP-catalyzed Curtius rearrangement and intramol. cyclization cascade reaction of 2-substituted aryl carboxylic acids with organic azides was reported for the first time. This protocol featured simple operation, broad scope and metal-free conditions, furnishing a broad spectrum of biol. attractive heterocycles. The synthetic virtue of this reaction was demonstrated by gram-scale synthesis and applicability toward drug-like mols. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Recommanded Product: 89-77-0

The Article related to benzoic acid carbonyl azide dmap catalyst curtius rearrangement cyclization, quinolinone benzoimidazolone benzooxazolone benzothiazolone preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 5, 2021, Sun, Bin; Huang, Panyi; Yan, Zhiyang; Shi, Xiayue; Tang, Xiaoli; Yang, Jin; Jin, Can published an article.Product Details of 89-77-0 The title of the article was Self-Catalyzed Phototandem Perfluoroalkylation/Cyclization of Unactivated Alkenes: Synthesis of Perfluoroalkyl-Substituted Quinazolinones. And the article contained the following:

A novel visible-light-induced radical tandem trifluoromethylation/cyclization of unactivated alkenes with sodium perfluoroalkanesulfinates (Rf = CF3, C3F7, C4F9, C6F13, C8F17) under air atm. was developed. A range of quinazolinones containing unactivated alkene moiety and sodium perfluoroalkanesulfinates were compatible with this transformation, leaded to a variety of perfluoroalkyl-substituted quinazoline alkaloids. Remarkably, the experiment was carried out without any metal catalyst, strong oxidant, or external photosensitizer. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0

The Article related to alkenyl quinazolinone perfluoroalkanesulfinate regioselective phototandem perfluoroalkylation cyclization, dihydrocyclicquinazolinonyl trifluoroalkane preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bai, Chaolumen; Chao, Bao; Muschin, Tegshi; Bao, Agula; Baiyin, Menghe; Liu, Dan; Bao, Yong-Sheng published an article in 2021, the title of the article was Regiodivergent CDC reactions of aromatic aldehydes with unactivated arenes controlled by transient directing strategy.Name: 2-Amino-4-chlorobenzoic acid And the article contains the following content:

The regiodivergent catalytic dehydrogenative cross-coupling reactions at both sp2 and sp3 hybridized carbons of aromatic compounds are particularly challenging. Herein, the finding of transient directing group controlled regiodivergent C(sp3)-C(sp2) and C(sp2)-C(sp2) cross-coupling in the o-Me benzaldehyde frameworks 2-CH3RC6H3CHO (R = H, 6-Me, 4-Br, 4,6-(CH3)2, etc.) is reported. Catalyzed by palladium, using K2S2O8 or [F+] reagents as by-standing oxidants and unactivated arenes R1C6H5 (R1 = H, OEt, Me, Cl, etc.) as substrates/solvents, various benzyl benzaldehydes RC6H3CHO-2-CH2C6H4R1 or Ph benzaldehydes R-2-MeC6H2CHOC6H4R1 were prepared A mechanism study indicated that the regiospecificity is dominated by the [5,6]-fused palladacycle or [6,5]-fused palladacycle intermediates, which are generated from Pd-chelation with specified transient directing groups and further C-H activations. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to benzylbenzaldehyde preparation regioselective, phenylbenzaldehyde preparation regioselective, arene aromatic aldehyde coupling reaction palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Aldehydes and Derivatives, Including Sulfur Analogs and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 21, 2020, Li, Quanzhe; Liu, Jiaxin; Wei, Yin; Shi, Min published an article.Related Products of 89-77-0 The title of the article was One-Pot Synthesis of Spirocyclopenta[a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization. And the article contained the following:

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramol. Friedel-Crafts-type cyclization from propargyl alc.-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to spirocyclopentaindene derivative preparation, propargyl alc tethered alkylidenecyclobutane preparation cascade ring expansion cyclization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Jiayu; Liu, Dan; Bai, Chaolumen; Bao, Agula; Muschin, Tegshi; Baiyin, Menghe; Bao, Yong-Sheng published an article in 2021, the title of the article was Transient directing group controlled regiodivergent C(sp3)-H and C(sp2)-H polyfluoroalkoxylation of aromatic aldehydes.Reference of 2-Amino-4-chlorobenzoic acid And the article contains the following content:

A novel method for achieving regiodivergent C(sp3)-H and C(sp2)-H polyfluoroalkoxylation in the o-Me benzaldehydes R-2-MeC6H3CHO (R = 3-Me, 4-MeO, 5-Br, etc.) framework by altering the transient directing group is disclosed. Using palladium as the catalyst and [F+] reagents as bystanding oxidants, various regioisomeric polyfluoroalkoxylated benzaldehydes R-6-C(CF3)2O-2-MeC6H2CHO and R-2-C(CF3)2OCH2C6H3CHO were prepared It is proposed that the selectivity is governed by the size of the palladacycle which is generated from Pd-chelation with different transient directing groups and helps in harnessing palladium with the benzyl C(sp3)-H or C(sp2)-H bonds of o-Me benzaldehydes. These findings provide an avenue for controlled regiodivergent C(sp3)-H and C(sp2)-H functionalization reactions. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid

The Article related to benzaldehyde polyfluoroalkoxy preparation regioselective, methyl benzaldehyde hexafluoroisopropanol polyfluoroalkoxylation transient directing group palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Reference of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 21, 2021, Seo, Sangwon; Gao, Ming; Paffenholz, Eva; Willis, Michael C. published an article.Related Products of 89-77-0 The title of the article was Sequential Catalytic Functionalization of Aryltriazenyl Aldehydes for the Synthesis of Complex Benzenes. And the article contained the following:

We demonstrate that aryltriazenes can promote three distinctive types of C-H functionalization reactions, allowing the preparation of complex benzene mols. with diverse substitution patterns. 2-Triazenylbenzaldehydes are shown to be efficient substrates for Rh(I)-catalyzed intermol. alkyne hydroacylation reactions. The resulting triazene-substituted ketone products can then undergo either a Rh(III)-catalyzed C-H activation, or an electrophilic aromatic substitution reaction, achieving multifunctionalization of the benzene core. Subsequent triazene derivatization provides traceless products. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to triazenylbenzaldehyde hydroacylation rhodium sequential catalysis bromination one pot, complex benzene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rong, Nianxin; Yuan, Yongsheng; Chen, Huijie; Yao, Changguang; Li, Teng; Wang, Yantao; Yang, Weiran published an article in 2021, the title of the article was A practical route to 2-iodoanilines via the transition-metal-free and base-free decarboxylative iodination of anthranilic acids under oxygen.Name: 2-Amino-4-chlorobenzoic acid And the article contains the following content:

A simple and practical procedure for synthesizing 2-iodoanilines ArNH2 [Ar = 2-IC6H4, 2-I-4-BrC6H3, 2-I-4-MeOC6H3, etc.] had been developed. A series of highly regioselective 2-iodoanilines ArNH2 was obtained in satisfactory to good yields (of up to 90%) by carrying out the decarboxylative iodination of readily available anthranilic acids with inexpensive KI and I2 as halogen donors under transition-metal-free and base-free conditions. Oxygen was shown to be necessary for the transformation. This practical decarboxylative iodination route was operationally scalable and shown to exhibit high functional-group tolerance. Control experiments suggested that a radical pathway was involved in the transformation. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to iodoaniline regioselective preparation, anthranilic acid oxygen decarboxylative iodination, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 25, 2020, Guo, Jialin; Luo, Longlong; Wang, Zhihong; Hu, Naijing; Wang, Wei; Xie, Fei; Liang, Erguang; Yan, Xinlin; Xiao, Junhai; Li, Song published an article.Quality Control of 2-Amino-4-chlorobenzoic acid The title of the article was Design, Synthesis, and Biological Evaluation of Linear Aliphatic Amine-Linked Triaryl Derivatives as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction with Promising Antitumor Effects In Vivo. And the article contained the following:

A series of novel linear aliphatic amine-linked triaryl derivatives as inhibitors of PD-1/PD-L1 were designed, synthesized, and evaluated in vitro and in vivo. In this chem. series, compound I showed the most potent inhibitory activity and binding affinity with hPD-L1, with an IC50 value of 12 nM and a KD value of 16.2 pM, showing a binding potency approx. 2000-fold that of hPD-1. Compound I could bind with hPD-L1 on the cellular surface and competitively block the interaction of hPD-1 with hPD-L1. In a T cell function assay, I restored the T cell function, leading to increased IFN-γ secretion. Moreover, in a humanized mouse model, compound I significantly inhibited tumor growth without obvious toxicity and showed moderate PK properties after i.v. injection. These results indicated that I is a promising lead for further development of small-mol. PD-1/PD-L1 inhibitors for cancer therapy. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Quality Control of 2-Amino-4-chlorobenzoic acid

The Article related to linear aliphatic amine linked triaryl preparation, programmed cell death 1 ligand sar antitumor pharmacokinetics, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Quality Control of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2020, Guru, Murali Mohan; Thorve, Pradip Ramdas; Maji, Biplab published an article.Related Products of 89-77-0 The title of the article was Boron-Catalyzed N-Alkylation of Arylamines and Arylamides with Benzylic Alcohols. And the article contained the following:

A sustainable boron-based catalytic approach for chemoselective N-alkylation of primary and secondary aromatic amines and amides with primary, secondary, and tertiary benzylic alcs. have been presented. The metal-free protocol operates at low catalyst loading, tolerates several functional groups and generates H2O as the sole byproduct. Preliminary mechanistic studies were performed to demonstrate the crucial role of boron catalyst for the activation of the intermediate dibenzyl ether and to identify the rate-determining step. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to arylamine arylamide benzylic alc chemoselective alkylation boron green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 12, 2022, Sharma, Swagat; Peng, Qi; Vadukoot, Anish K.; Aretz, Christopher D.; Jensen, Aaron A.; Wallick, Alexander I.; Dong, Xinzhong; Hopkins, Corey R. published an article.Application of 89-77-0 The title of the article was Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1. And the article contained the following:

The present study describes the continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides e.g., 3-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)-2-naphthamide as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid receptor for the potential treatment of chronic pain. Working from the original compound, ML382, and utilizing iterative medicinal chem., key halogen substituents that improve MrgX1 potency by ~8-fold were identified. In addition, the compounds in Tier 1 drug metabolism and pharmacokinetics assays were evaluated and the key compounds that impart improved potency and microsomal stability were identified. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application of 89-77-0

The Article related to sulfonamidebenzamide preparation allosteric modulator protein coupled receptor, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics