Category: 89794-02-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89794-02-5, name is 4-Bromo-2-chlorotoluene, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Bromo-2-chlorotoluene

4-Bromo-2-chloro-l-methylbenzene (CAS 89794-02-5, 30 g, 0.15 mol) and N-bromosuccinirnide (26 g, 0.15 mol) were mixed in CCl4 (300 mL). Azobis(2- methylpropionitrile) (-0.3 g) was added in portions under vigorous stirring and refluxing. The mixture was refluxed for 30 min and cooled. The precipitate was filtered off and discarded. The filtrate was evaporated. The residue was distilled at 1 mmHg, bp 75 0C to give the title compound (28 g, 65%). 1H nuMR data (CDCl3): delta 7.57 (d, J=I .9 Hz, IH ArH), 7.39 (dd, IH, Ji=I.9 Hz, J2=S-I Hz, ArH), 7.31 (d, IH, J=I .9 Hz, ArH), 4.53 (s, 2H, ArCH2).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/49123; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 89794-02-5, name is 4-Bromo-2-chlorotoluene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89794-02-5, Recommanded Product: 4-Bromo-2-chlorotoluene

Example 3 bis(3-chloro-4-methylphenyl)borate After ignition drying of magnesium piece (0.97g) in vacuo and purging with argon, anhydrous THF (40ml) and 1,2-dibromoethane (a few drops) were added.. Solution of 3-chloro-4-methylphenyl bromide (6.2g) in THF (20ml) was delivered by drops to the mixture over one hour at room temperature and the reaction mixture was heated to reflux for 30 minutes.. The reaction mixture was cooled to room temperature and added slowly to solution of trimethyl borate (1.36ml) in THF (20ml) cooled to -78C and the mixture was left standing to be warmed to room temperature. 1N hydrochloric acid (100ml) was added to the reaction mixture and the water layer was extracted with ethyl acetate.. The organic layer was dried with anhydrous sodium sulfate and concentrated.. The residue was purified by column chromatography (ethyl acetate: hexane = 1: 1), and the obtained solid was recrystallized to obtain the title compound (2.89g) having the following physical data. TLC: Rf 0.38 (ethyl acetate: hexane = 1:1); NMR (200 MHz, CDCl3): delta 7.72 (2H, s), 7.53 (2H, d, J = 7 Hz), 7.29 (2H, d, J = 7 Hz), 5.7-6.0 (1H, br), 2.45 (6H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chlorotoluene, and friends who are interested can also refer to it.

Reference:
Patent; Mikoshiba, Katsuhiko; EP1444981; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 89794-02-5,Some common heterocyclic compound, 89794-02-5, name is 4-Bromo-2-chlorotoluene, molecular formula is C7H6BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of aryl bromide (3 equiv), Mg (3 equiv), and DIPAB or DICAB (1 equiv) in dry THF (1 mL/mmol) was added at r.t. a solution of 2 M PhMgBr in THF (0.05 equiv). After 10 min (or at the end of gas evolution on large scale), the mixture was heated to 70 C until no aryl bromide remained in the mixture (8-16 h). At 0 C, dry MeOH (1mL/mmol) was added (caution, exothermic reaction). After 1 h, the mixture was concentrated under reduced pressure, and diluted in a mixture of 1 M HCl/MeOH (7:3, 10 mL/mmol), after 1 h, the product was extracted with Et2O (3 ¡Á 10 mL/mmol) and the combined organic phases were washed with 1 M HCl (10 mL/mmol) and brine (3 ¡Á 10mL/mmol). Organic phases were then dried (anhyd Na2SO4), and concentrated under reduced pressure. The residue was dissolved in Et2O (4 mL/mmol) and ethanolamine (1.2 equiv) was added. Depending on the substituents, precipitation occurs spontaneously or requires the addition of pentane. Crystals were filtered, washed with pentane and dried under vacuum to yield the pure 2-aminoethyl borinate.

The synthetic route of 89794-02-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Richard, Jimmy; Birepinte, Melodie; Charbonnier, Jean Baptiste; Liautard, Virginie; Pinet, Sandra; Pucheault, Mathieu; Synthesis; vol. 49; 4; (2017); p. 736 – 744;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 89794-02-5, name is 4-Bromo-2-chlorotoluene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89794-02-5, Product Details of 89794-02-5

Example P14: Preparation of 2-(4-bromo-2-chlorophenyl)-1-methyl-ethylamine (compound no. Z1.451): a) Preparation of 4-bromo-2-chloro-1-dibromomethyl-benzeneA mixture of 4-bromo-2-chlorotoluene (10 g, 48.6 mmol), N-bromosuccinimide (43.3 g, 243.3 mmol), benzoyl peroxide (0.5 g) and CCI4 (80 ml) was heated to reflux for 6 h. Completion of the reaction was confirmed by TLC. After cooling a yellow precipitate was isolated by filtration and washed with CCI4. The organic layer was concentrated and both the concentreated organic layer and the precipitate were purified by chromatography using silica column (60-120 mu mesh) and hexane as eluent. 17.5 g (98% of theory) of 4-bromo-2-chloro- 1-dibromomethyl-benzene was obtained. 1HNMR (400 MHz, CDCI3):- 7.02 delta (s, 1 H), 7.5 delta (dd, 2H), 7.87 delta (d,1H,CHBr2),

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; WO2007/141009; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89794-02-5, name is 4-Bromo-2-chlorotoluene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-2-chlorotoluene

Example 3 Bis(4,4′-(3-chloro-4-methylphenylhydroxyboryl)benzyl) ether; [Show Image] Bis(4-bromobenzyl) ether (157 mg) was dissolved in 8 mL of ether, and the solution was cooled to -78C. After addition of 2 mL of a 1 M sec-BuLi solution, the mixture was stirred for two hours (solution A). 4-Bromo-2-chlorotoluene (205 mg) was dissolved in 8 mL of ether, and the solution was cooled to -90C. After addition of 2 mL of a 1 M sec-BuLi solution, the mixture was stirred for two hours. Triisopropoxyborane (0.46 mL) was added to the resulting solution, and the mixture was stirred for 1.5 hours. The solution A was added to the solution, and the mixture was gradually returned to room temperature and stirred overnight. Aqueous dilute hydrochloric acid was added, and the mixture was stirred. The organic layer was dried and then concentrated and applied to a silica gel column to give 77 mg of the entitled compound as a grease. Rf= 0.48 (EtOAc, Hexane 1: 1) NMR (CDCl3) 2.35 (s, 6H), 4.53 (s, 4H), 7.1-8.2 (m, 14H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89794-02-5.

Reference:
Patent; Japan Science and Technology Agency; EP1961756; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 89794-02-5, name is 4-Bromo-2-chlorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Bromo-2-chlorotoluene

(i) Alkoxycarbonylation reactions of different aryl bromides using different phosphonium salts 0.0025 mmol Pd(OAc)2, 0.0075 mmol ligand (phosphonium salt) and 0.385 mmol TMEDA were diluted with n-butanol to a total volume of 10 ml. 0.5 mmol of each substrate was introduced directly in the autoclaves, and then 1 ml of the catalyst solution was added to the autoclave. After purging with carbon monoxide the pressure was set to 25 bar CO and the autoclave was stirred while warming up to 115C. The reactions were hold at 115C for 20h. After cooling down and releasing the pressure the raw mixtures were filtered through a short path of Al2O3 and the conversion was determined via GC.

The synthetic route of 4-Bromo-2-chlorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Evonik Degussa GmbH; EP1894938; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics