Category: 89938-53-4

3-Benzo[b]furyl- and 3-benzo[b]thienylaminobutyric acids as GABA_B ligands. Synthesis and structure-activity relationship studies was written by Ansar, M.;Ebrik, S. Al Akoum;Mouhoub, R.;Berthelot, P.;Vaccher, C.;Vaccher, M. P.;Flouquet, N.;Caignard, D. H.;Renard, P.. And the article was included in European Journal of Medicinal Chemistry in 1996.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde The following contents are mentioned in the article:

Baclofen (β-p-chlorophenyl GABA) is one of the selective agonists for the bicuculline-insensitive GABA_B receptors. In the search for new compounds that bind to GABA_B receptors it is very important to clarify the structural requirements. The syntheses of the binding studies on various 3-heteroaromatic (benzo[b]furyl- and benzo[b]thienyl)aminobutyric acids is reported. 4-Amino-3-(7-methyl-benzo[b]furan-2-yl)butanoic acid (I) is a potent and specific ligand for GABA_B receptors, with an IC₅₀ value of 5.4 μM in the displacement of [³H]GABA. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates was written by Wang, Jane L.;Aston, Karl;Limburg, David;Ludwig, Cindy;Hallinan, Ann E.;Koszyk, Francis;Hamper, Bruce;Brown, David;Graneto, Matthew;Talley, John;Maziasz, Timothy;Masferrer, Jaime;Carter, Jeffery. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Reference of 89938-53-4 The following contents are mentioned in the article:

In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data. The challenge of a surprisingly long half-life (t _1/2 = 360 h) of the first clin. candidate 1 and human t _1/2 had been difficult to predict based on allometric scaling for this class of highly ppb compounds We used a microdose strategy which led to the discovery of clin. agents 18c-(S), 29b-(S), and 34b-(S) with human half-life of 57, 13, and 11 h. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Reference of 89938-53-4).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 89938-53-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468) was written by Bouchmaa, Najat;Ben Mrid, Reda;Boukharsa, Youness;Nhiri, Mohamed;Ait Mouse, Hassan;Taoufik, Jamal;Ansar, M’hammed;Zyad, Abdelmajid. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2018.HPLC of Formula: 89938-53-4 The following contents are mentioned in the article:

Triple-neg. breast cancer (TNBC) is a complex and aggressive subtype of breast cancer characterized by high morbidity and mortality. In the absence of targeted therapy, only chemotherapy is available in this case of cancer. The current study investigated the antitumor effect of new pyridazin-3(2H)-one derivatives on the human TNBC cell line, MD-MB-468. The in vitro cytotoxic activities were investigated using the tetrazolium-based MTT assay. Lipid peroxidation, H₂O₂ content, and the specific activities of antioxidant enzymes were also determined Two mols., 6f and 7h, were found to be selectively highly active against tumor cells with IC₅₀ values of 3.12 and 4.9 μM, resp. Furthermore, cells exposed to 6f showed a significant increase in H₂O₂ and lipid peroxidation levels, accompanied by a decrease in the enzyme activities of glutathione reductase (GR) and thioredoxin reductase (TrxR). The cytotoxicity of the compound 6f may improve the therapeutic efficacy of the current treatment for TNBC via the inhibition of GR and TrxR activities. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4HPLC of Formula: 89938-53-4).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 89938-53-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fungitoxic derivatives of salicylaldehyde. II. Chlorinated and brominated derivatives of salicylideneaniline and related compounds as eradicants of cucumber powdery mildew was written by Smith, R. J.;Read, W. H.. And the article was included in Annals of Applied Biology in 1961.Safety of 3-Chloro-2-hydroxy-5-methylbenzaldehyde The following contents are mentioned in the article:

Halogenated derivatives of salicylideneaniline were prepared by condensation between salicylaldehyde. or its appropriate derivative, and aniline, or the appropriate monochlorinated aniline, in warm EtOH. The most promising compounds for eradicating Erysiphe cichoracearum were 3-bromo- and 3-chlorosalicylideneaniline. Although more effective at 0.08-0.10% than Karathane sprays on a com. scale, these compounds showed phytotoxic effects on mature cucumber plants. Their toxicity to certain other fungi was also reported. The salicylidene substituents, aniline substituents, derivative, crystalline form, recrystallization solvent, and m.p. were given: 3-Cl, -, pale orange needles, EtOH (I), 59.5-60.0°; 3-Cl, 2-Cl, golden yellow needles, 80% I, 142.0-2.5°; 3-Cl, 3-Cl, deep-yellow prisms, 80% I, 104°; 3-Cl, 4-Cl, orange prisms, I, 108-9° 4-Cl, -, deep-yellow needles, 80% I, 69.5°; 5-Cl, -, orange needles, I, 109.0-9.5°; 5-Cl, 4-Cl, deep-yellow platelets, AcOH-C₆H₆-ligroine, 147-8°; 3,5-Cl₂, -, orange, I, 102-3°; 3,5-Cl₂, 4-Cl, red-orange needles, 90% AcOH, 139-40°; 3,5-ClMe, -, tangerine needles, 90% I, 51.0-2.5°; 3-Br, -, orange needles, 80% I, 70.5°; 3,5-BrCl, -, deep-orange, I, 86-7°; 3,5-Br₂, -, orange-red needles, 95% I, 90.0-90.5°; 3,5-BrMe, -, orange needles, 95% I, 62° (softening at 60°); 3-Cl (Cu compound) -, -, -, 198-200°; 3-MeO, -, orange-red needles or prisms, 75% I, 84.0-4.5°. The following aniline derivatives were also prepared (same data given): 2-hydroxynaphthylideneaniline, golden-yellow needles, 70% I, 93.0-3.5°; 3-chloro-4-hydroxybenzylideneaniline, glistening yellow-ochre needles, 50% I, 167-8°; benzylidene-4-chloro-2-hydroxyaniline silver plates, 50% I, 108°. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Safety of 3-Chloro-2-hydroxy-5-methylbenzaldehyde).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3-Chloro-2-hydroxy-5-methylbenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics