Category: 89978-31-4

El-Gendy, Z. published the artcileBiologically active thiazolidinone. Part-II. Synthesis and fungitoxicities of isolated and fused thiazolidinones derived from thiosemicarbazones, Recommanded Product: 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is thiazolidinone preparation fungicide; structure activity thiazolidinone fungicide; thiosemicarbazone fungicidal activity conversion thiazolidinone.

The preparation and fungicidal activity of thiazolidinones, e.g., I, and of the precursor thiosemicarbazones, e.g., 3,4-(HO)2C6H3CH:NNC(S)NH2 (II), are reported. Thus, cyclocondensation of II with ClCH2CO2H gave I which cyclocondensed with HSCH2CO2H to give (oxothiazolidinylamino)thiazolidinone III. III was the most active compound prepared The structure activity relationship is discussed.

Journal of the Indian Chemical Society published new progress about Fungicides. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Recommanded Product: 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cakir, Gizem published the artcileNovel 4-Thiazolidinones as Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase, Related Products of chlorides-buliding-blocks, the main research area is thiazolidinone hepatitis C virus NS5B RNA dependent polymerase inhibitor; 4-Thiazolidinones; Antiviral agents; HCV NS5B polymerase; Hepatitis C; Molecular modeling.

In continuation of the authors efforts to develop new derivatives as hepatitis C virus (HCV) NS5B inhibitors, the authors synthesized novel 5-arylidene-4-thiazolidinones. The novel compounds 29-42, together with their synthetic precursors 22-28, were tested for HCV NS5B inhibitory activity; 12 of these compounds displayed IC50 values between 25.3 and 54.1 μM. Compound 33, an arylidene derivative, was the most active compound in this series with an IC50 value of 25.3 μM. Mol. docking studies were performed on the thumb pocket-II of NS5B to postulate the binding mode for these compounds

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antiviral agents. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nam, Nguyen-Hai published the artcileSynthesis, bioevaluation and docking study of 5-substituted phenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents, Quality Control of 89978-31-4, the main research area is thiadiazole hydroxamic acid preparation histone deacetylase inhibitor antitumor; 5-phenyl-1,3,4-thiadiazole; cytotoxicity; heterocycle; histone deacetylase (HDAC) inhibitors.

Since the first histone deacetylase (HDAC) inhibitor (Zolinza, widely known as suberoylanilide hydroxamic acid; SAHA) was approved by the Food and Drug Administration for the treatment of T-cell lymphoma in 2006, the search for newer HDAC inhibitors has attracted a great deal of interest of medicinal chemists worldwide. As a continuity of the ongoing research in this area, the authors designed and synthesized a series of thiadiazole-based hydroxamic acids I [R = H, 2-Cl, 4-Me, etc.] as analogs of SAHA and evaluated their biol. activities. A number of compounds in this series, e.g. I [R = H], I [R = 2-Cl], I [R = 4-MeO], were found to possess potent anticancer cytotoxicity and HDAC inhibition effects. These compounds were generally two- to five-fold more potent in terms of cytotoxicity compared to SAHA against five cancer cell lines tested. Docking studies revealed that these hydroxamic acid displayed higher affinities than SAHA toward HDAC8.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Quality Control of 89978-31-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hilfiker, Mark A. published the artcileDiscovery of novel aminothiadiazole amides as selective EP3 receptor antagonists, Application In Synthesis of 89978-31-4, the main research area is aminothiadiazole amide preparation antagonist EP3 receptor.

This Letter discloses a series of 2-aminothiadiazole amides as selective EP3 receptor antagonists. Structure-activity relationship (SAR) optimization resulted in compounds with excellent functional activity in vitro. In addition, efforts to optimize DMPK properties in the rat are discussed. These efforts have resulted in the identification of potent, selective EP3 receptor antagonists with excellent DMPK properties suitable for in vivo studies.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug bioavailability. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Application In Synthesis of 89978-31-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics