Design, synthesis, and characterization of rhein analogs as novel inhibitors of scavenger receptor A was written by Zheng, Yi;Li, Xia;Pagare, Piyusha P.;Yuan, Yunyun;Wang, Xiang-Yang;Zhang, Yan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Reference of 90064-48-5 This article mentions the following:
Scavenger receptor A (SRA) has been known as an immunosuppressive factor and therefore therapeutic inhibition of SRA may be potentially exploited for cancer immunotherapy. The previous work suggested that rhein may act as an inhibitor of SRA in reversing immunosuppression of SRA during T cells activation. Herein, three deconstruction analogs of rhein were further studied as inhibitors of SRA. These three compounds, particularly compound I, also known as a natural product danthron, enhanced T cells activation, indicated by increased transcriptional activation of interleukin 2 (Il2) gene, production of IL-2 protein, and proliferation of T cells. Addnl., the interaction between these compounds and SRA was studied by mol. modeling. Compound I showed a favorable binding mode with the cysteine rich domain of SRA protein compared to the other compounds Collectively, those results would provide insight for future design and development of next generation rhein derivatives as SRA inhibitors. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5Reference of 90064-48-5).
4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 90064-48-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics