Benzylamines: synthesis and evaluation of antimycobacterial properties was written by Meindl, Wolfgang R.;Von Angerer, Erwin;Schoenenberger, Helmut;Ruckdeschel, Gotthard. And the article was included in Journal of Medicinal Chemistry in 1984.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine The following contents are mentioned in the article:
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra were described. The most active compounds: I.HCl (MIC 10.2 μg/mL), II. HCl (MIC 10.2 μg/mL), and III.HCl (MIC 6.4 μg/mL), also had a marked inhibitory effect on M. marinum and M. lufu. The combination of II with aminosalicylic acid, streptomycin, or dapsone had marked supra-additive effects on M. tuberculosis H 37 Ra. This study involved multiple reactions and reactants, such as 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine).
1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics