Category: 90906-61-9

Lee, Jia-Shuai published the artcilePreparation of D-phenylglycinyl derivatives of cefuroxime as double ester prodrugs, HPLC of Formula: 90906-61-9, the publication is Chinese Pharmaceutical Journal (Taipei) (1997), 49(3), 195-205, database is CAplus.

D-Phenylglycine was attached at the 4-COOH of cefuroxime via an ethylidene linkage to form double ester derivatives The D-phenylglycine moiety was considered as a tool for delivering the poorly absorbed cefuroxime through the intestine. The Δ³ â†?Δ² isomerization commonly reported along the preparation of cephalosporin esters was successfully eliminated by adding TBA ⁺HSO₄^– as phase transfer catalyst in the alkylation reaction. The prodrugs were stable in acidic phosphate buffer solutions, but degraded fairly rapidly in pH 7.39 phosphate buffer solution and in rat intestinal mucosa suspension. The t_1/2 for these 2 drugs were 10 min and 5 min resp., indicating that both compounds fail to demonstrate satisfactory stability for formulation as oral prodrugs of cefuroxime.

Chinese Pharmaceutical Journal (Taipei) published new progress about 90906-61-9. 90906-61-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1-Chloroethyl sulfochloridate, and the molecular formula is C2H4Cl2O3S, HPLC of Formula: 90906-61-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binderup, E. published the artcileChlorosulfates as reagents in the synthesis of carboxylic acid esters under phase-transfer conditions, SDS of cas: 90906-61-9, the publication is Synthetic Communications (1984), 14(9), 857-64, database is CAplus.

Chlorosulfates ClSO₃R (R = CH₂Cl, Me, CHMeCl, Bu, Et) and (ClSO₃)₂CH₂ were used to esterify several carboxylic acids, i.e., penicillanic acid derivatives, BzOH, and alkanoic acids. Thus, penicillanic acid sulfone was converted to the chloromethyl ester by treatment with ClSO₃CH₂Cl in H₂O-CH₂Cl₂ in the presence of NaHCO₃ and Bu₄N⁺HSO₄^–.

Synthetic Communications published new progress about 90906-61-9. 90906-61-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1-Chloroethyl sulfochloridate, and the molecular formula is C2H4Cl2O3S, SDS of cas: 90906-61-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics