Category: 909122-17-4

Related Products of 909122-17-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 909122-17-4, name is 1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

First Step 2.6 g of well dried magnesium and 20 mL of THF were added to a reactor in a nitrogen atmosphere and heated to 40° C. 26.6 g of the compound (C12) dissolved in 80 mL of THF was added dropwise thereto slowly in a temperature range of 30 to 45° C., followed by stirring for 20 minutes. Thereafter, 21.2 g of a compound (b45) dissolved in 20 mL of THF was added dropwise thereto slowly in a temperature range of 30 to 35° C., followed by stirring for 60 minutes. The resulting reaction mixture was cooled to 25° C. and then poured into 100 mL of 3N hydrochloric acid and 100 mL of toluene, followed by mixing. The mixture was then left to rest to separate into an organic layer and an aqueous layer, followed by extracting to the organic layer. The resulting organic layer was collected and washed with water, a 2N sodium hydroxide aqueous solution, a saturated sodium hydrogen carbonate aqueous solution and water, followed by drying over anhydrous magnesium sulfate. Thereafter, the solvent was distilled off under reduced pressure to obtain 47.0 g of 4-(2-chloro-4-ethoxy-3-fluorophenyl)-trans-4′-propyl-bicyclohexyl-4-ol (b48). The resulting compound (b48) was a yellow oily substance.

The synthetic route of 1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Goto, Yasuyuki; Shimada, Teru; Sugiura, Teruyo; US2006/198968; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 909122-17-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 909122-17-4 name is 1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

First Step 1.0 g of well dried magnesium and 30 mL of THF were placed in a reactor under nitrogen atmosphere, and heated to 43° C. 10.0 g of 1-bromo-2-chloro-4-ethoxy-3-fluorobenzene (6) dissolved in 20 mL of THF was slowly added dropwise thereto at a temperature range of from 43 to 51° C., followed by stirring for 30 minutes. Thereafter, 21.2 g of 4-(2-(trans-4-propylcyclohexyl)ethyl)cyclohexanone (7) dissolved in 20 mL of THF was slowly added dropwise thereto at a temperature range of from 50 to 55° C., followed by stirring for 30 minutes. After cooling the resulting reaction mixture to 25° C., the reaction mixture was mixed with 100 mL of 3N hydrochloric acid and 100 mL of toluene in a vessel and separated into an organic layer and an aqueous layer by standing still, so as to attain extraction to the organic layer. The resulting organic layer was fractionated and washed with water, a 2N sodium hydroxide aqueous solution, a saturated sodium bicarbonate aqueous solution and water, followed by drying over anhydrous magnesium sulfate. Thereafter, the solvent was removed by distillation under reduced pressure to obtain 16.4 g of 1-(2-chloro-4-ethoxy-3-fluorophenyl)-4-(2-(trans-4-propylcyclohexyl)ethyl)cyclohexanol (8). The resulting compound (8) was a yellow solid matter.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Chisso Corporation; Chisso Petrochemical Corporation; US2008/75891; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics