Category: 90940-40-2

Zhang, Muliang; Yuan, Xiang-Ai; Zhu, Chengjian; Xie, Jin published the artcile< Deoxygenative Deuteration of Carboxylic Acids with D2O>, Application of C10H9ClO2, the main research area is deuterated aryl alkyl aldehyde chemoselective preparation; chemoselective photochem reduction deuteration aryl alkyl aldehyde iridium photocatalyst; phenylphosphine phenylphosphinite oxygen acceptor chemoselective deuteration reduction aldehyde; aldehydes; carboxylic acids; deoxygenation; deuteration; synergistic catalysis.

C1-Deuterated aryl and alkyl aldehydes such as 4-PhC6H4CDO and PhCH2CH2CDO were prepared chemoselectively with 58-96% deuterium incorporation by reduction of aromatic and aliphatic carboxylic acids using iridium photocatalysts, either Ph3P or Ph2OEt as an oxygen acceptor, 2,4,6-i-Pr3C6H2SH as a hydrogen atom donor, and using D2O as an inexpensive deuterium source. The method was used for the preparation of deuterated derivatives of pharmaceuticals and natural products containing aromatic carboxylic acid moieties. The method was also used for chemoselective reduction of aryl and alkyl carboxylic acids to the corresponding aldehydes using H2O as a hydrogen atom source.

Angewandte Chemie, International Edition published new progress about Acidity. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Application of C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhatt, M. V. published the artcile< Quinone studies. I. Evidence for a new type of substitution reaction of phenanthrenequinone derivatives>, Quality Control of 90940-40-2, the main research area is .

The para orientation by the carbonyl groups in the bromination of phenanthrenequinone (I) derivatives was explained on the basis of a reaction between Br atoms and an excited state resulting from the thermal excitation of the quinone and (or) from an n → π* transition of the non-bonding electrons of the oxygen atoms. A method for synthesis of 3-bromophenanthrenequinone (II) derivatives consists of irradiating with a 75 w. tungsten lamp, a mixture of 0.01 mole the quinone, 0.02 mole Br, and 100 mg. (BzO)2 in 10 ml. PhNO2, at 60 ± 10° 1-2 hrs. The residue obtained after steam distillation of the reaction mixture yielded 80-6% the bromo derivative Thus, 0.02 mole 2-nitrophenanthrenequinone (III), 0.04 mole Br, and 100 mg. (BzO)2 in 10 ml. PhNO2 was irradiated during 2 hrs., 25 ml. EtOH added to the reaction mixture, and the mixture cooled in ice to yield 80% 2-nitro-6-bromophenanthrenequinone (IV) in yellow plates, m. 318-18.5° (PhNO2); quinoxaline derivative m. 318-18.5° (xylene). Oxidation of 1 g. IV in 20 ml. AcOH with 5 ml. ∼25% H2O2 at reflux temperature 3 hrs. and purification (NaHCO3 solution) yielded light brown cubes (AcOH) of 2-nitro-5′-bromodiphenic acid (V), m. 271-2°. The structure of IV was established by degradation. A mixture of 2.0 g. IV, 4.0 g. granulated Sn, 70 ml. EtOH, 30 ml. concentrated HCl, and 30 ml. H2O was heated on a water bath 3 hrs., filtered, mixed with 100 ml. concentrated HCl, cooled in a freezing mixture, a light yellow solid separated, dissolved in H2O, and basified (NaOH), and air bubbled. Dark pink 2-amino-6-bromophenanthrenequinone (VI) formed was separated (1 g.) and crystallized, m. >360° (PhNO2); yellow quinoxaline derivative m. 360° (AcOH). A solution of 0.3 g. VI in 3 ml. concentrated H2SO4 was cooled in a freezing mixture 0.5 hr. and an aqueous solution of 3 g. NaHPO2.H2O added and kept 24 hrs. The yellow solid was separated, sublimed, and crystallized (AcOH) to yield orange yellow plates, m. 267-8°, of 3-bromophenanthrenequinone (VII). Finely powd. IV (2 g.) was added with stirring to a boiling solution containing 10 g. KMnO4 and 20 g. KOH in 200 ml. H2O and the mixture stirred another hr., cooled, diluted, and filtered. The solid was boiled with NaHSO3 solution to dissolve MnO2 and filtered and the residue of 2-nitro-6-bromofluorenone (VIII) crystallized (xylene) in yellow flakes, m. 264-5°; oxime m. 256-7° (EtOH). In connection with synthesis of VIII, 5-nitroacetylanthranilic acid (IX) was prepared in 60-6% yield by nitrating 30 g. acetylanthranilic acid with 60 ml. HNO3 (sp. gr. 1.5) at 5° during 12 hrs. and at room temperature 1.5 hrs. Nitration of tosylanthranilic acid with HNO3 (sp. gr. 1.5) gave a product, m. 209-10°, different from 5-nitrotosylanthranilic acid. A CHCl3 solution (150 ml.) of the pseudo acid chloride (X) of 2-(4-bromobenzoyl)benzoic acid obtained from 36 g. acid and 27 g. PCl5, was added to 100 ml. liquid NH3. On evaporation of NH3 and trituration of the solid with Na2CO3 solution was obtained 35 g. pseudo amide (XI), m. 210-11° (EtOH), λ (CHCl3) 2.8 and 5.83 μ (Nujol) 2.8-3, 5.83, 6.0 μ. A solution obtained by mixing 6 g. XI, 30 ml. 10% aqueous NaOH, 30 ml. EtOH, and NaOBr solution (from 1.4 ml. Br and 100 ml. ice-cold 10% NaOH solution) was stirred 5 min. at 0°, refluxed 1 hr., and cooled to 0° to give 32-55% the amine (XII), m. 111-13° (EtOH). 2-(4-Bromobenzoyl)acetanilide (XIII) was obtained by warming 0.5 hr. (water bath) a mixture of 5 g. XII, 10 ml. Ac2O, and 2-3 drops concentrated H2SO4 0.5 hr., and pouring into water. Recrystallization (EtOH) gave transparent needles, m. 143.5-4.5°. Nitration of 1.5 g. XIII with 9 ml. HNO3 (sp. gr. 1.46) below 0° 1.5 hrs. and room temperature 3 hrs. and working up yielded 750 mg. 2-(4-bromobenzoyl)-4-nitroacetanilide (XIV), yellow, m. 207-8° (EtOH). A mixture of 300 mg. XIV and 2 ml. concentrated H2SO4 was heated on a water bath 5 min. Dilution yielded 250 mg. 2-(4-bromobenzoyl)-4-nitroaniline (XV), yellow, m. 201.5-2.0° (EtOH). A slurry obtained from 200 mg. XV in 2 ml. concentrated H2SO4 and 2 ml. H2O was treated with 0.3 ml. 30% aqueous NaNO2 solution below 0° 1 hr. and at water bath temperature 1 hr. The solid formed was washed with 20% NaOH and purified by sublimation and crystallization (xylene) to yield yellow flakes, m. 256-7°, identical with VIII (ultraviolet, infrared, mixed m.p., mixed m.p. of oxime). Nitration of 0.5 g. XIII with 1 ml. HNO3 (sp. gr. 1.5) at 0° 24 hrs. yielded 0.4 g. 2-(4-bromobenzoyl)-4,6(?)-dinitroacetanilide (XVI), m. 198-9.5° (AcOH). Hydrolysis of XVI with 20 ml. HCl and 10 ml. AcOH under reflux 2 hrs. yielded 1.1 g. 2-(4-bromobenzoyl)-4,6(?)-dinitroaniline (XVII), brown, m. 220-1° (EtOAc). Cooling the reaction mixture obtained during nitration of 20 g. I with 600 ml. HNO3 (sp. gr. 1.39-1.40) at 100-25° (20 min.) gave 42% III, m. 256-8°. A mixture of 5 g. III, 4 ml. Br, and 40 ml. AcOH was heated at 140 ± 5° 2 hrs. in a closed bottle. The greenish brown solid, 77%, m. 305-7°, was separated The m.p. of this material was not depressed when mixed with IV. M.ps. of the quinoxaline derivative, 318-18.5° (xylene), and diphenic acid derivative, 271-2° (AcOH), were undepressed when mixed with corresponding derivatives from IV. Heating a mixture of 90 mg. VII, 0.5 g. KMnO4, 4 g. KOH, and 10 ml. H2O 1 hr. and treatment of the solid with NaHSO3 solution furnished 20 mg. 3-bromofluorenone (XVIII), m. 163-4° (C6H6). Boiling a mixture of 27.6 g. XII, 60 ml. concentrated HCl, and 40 ml. H2O, filtering, and cooling in a freezing mixture gave the hydrochloride. A suspension of the hydrochloride was treated with 840 mg. NaNO2 in 10 ml. at 5°, stirred 0.5 hr., kept 0.5 hr., filtered and heated 2 hrs. The yellow solid formed was extracted with 3N NaOH and filtered to yield 1.65 g. residue. Vacuum sublimation and crystallization (C6H6) yielded yellow needles of XVIII, m. 163-4°. A solution of 1.78 g. AgNO3 in 10ml. H2O was added dropwise to a mixture of 2.1 g. I, 50 ml. AcOH, 0.5 ml. Br, 5 ml. HNO3, and 5 ml. H2O and the mixture refluxed 0.25 hr. The solid was extracted with hot AcOH and cooled to give 0.5 g. red needles of 2-bromophenanthrenequinone (XIX), m. 233-4°. Similarly, a solution of 3.4 g. AgNO3 in 20 ml. H2O was added to a mixture containing 2.1 g. I, 50 ml. AcOH, 20 ml. HNO3 (sp. gr. 1.42), and 1.1 ml. Br and the mixture refluxed 0.5 hr. When worked up as before 0.6 g. 2,7-dibromophenanthrenequinone was obtained, m. 323° (AcOH). A suspension of 300 mg. powd. I in 30 ml. CCl4 and 1.2 ml. Br in 10 ml. CCl4 was mixed and cooled 40 hrs. in ice to give 300 mg. red needles, Br complex of I, m. 170-5° (shrinking at 165°).

Tetrahedron published new progress about Bromination. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Quality Control of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Candish, Lisa; Lupton, David W. published the artcile< N-heterocyclic carbene cascade catalysis: Dual Bronsted/Lewis base rearrangement of cyclopropyl enol esters to dihydropyranones>, Formula: C10H9ClO2, the main research area is heterocyclic carbene cascade catalysis Bronsted Lewis base rearrangement; cyclopropyl enol ester dihydropyranone rearrangement.

The first example of Broensted/Lewis base cascade catalysis using an N-heterocyclic carbene was realized through the rearrangement of cyclopropyl esters to dihydropyranones. The scope and mechanism of this transformation was examined implicating a novel NHC-mediated electrocyclic cyclopropane rearrangement followed by an anionic oxy Claisen-rearrangement.

Chemical Science published new progress about Acylation (proton transfer and O-). 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Formula: C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh, P.; Rishikesan, R.; Kumari, N. Suchetha published the artcile< Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents>, SDS of cas: 90940-40-2, the main research area is aminothiazolylmethyl ester carboxylic acid preparation antimicrobial antitubercular; ester aminothiazolylmethyl preparation antimicrobial antitubercular; thiazolylmethyl ester carboxylic acid preparation antimicrobial antitubercular; crystal structure aminothiazolylmethyl ester chlorophenylcyclopropanoic acid.

A series of 20 (2-aminothiazol-4-yl)methylester derivatives were synthesized in good yields and characterized by 1H NMR, 13C NMR, mass spectral and elemental analyses. The crystal structure of I was determined and data are referenced. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.

European Journal of Medicinal Chemistry published new progress about Antimicrobial agents. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, SDS of cas: 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaiser, Carl; Lester, Bruce M.; Zirkle, Charles L.; Burger, Alfred; Davis, Charles S.; Delia, Thomas J.; Zirngibl, Ludwig published the artcile< 2-Substituted cyclopropylamines. I. Derivatives and analogs of 2-phenylcyclopropylamine>, Application In Synthesis of 90940-40-2, the main research area is .

A series of derivatives (I, II) of 2-phenylcyclopropylamine and analogs, 2-arylcyclopropanecarboxhydrazides, -carboxamides, -methyl-amines, -carboxylic acids, esters, and chlorides has been prepared in order to study relationships between chem. structure and monoamine oxidase-inhibiting activity.

Journal of Medicinal & Pharmaceutical Chemistry published new progress about 90940-40-2. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Application In Synthesis of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sasaki, Tadashi; Kanematsu, Ken; Minamoto, Katsumaro published the artcile< Morphine-like analgesics. II. Aminohydrophenanthrene derivatives>, Product Details of C10H9ClO2, the main research area is CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; MORPHINE; PHENANTHRENES.

A solution of 10 g. 2-phenylcyclohexanone in 25 ml. C6H6 is added dropwise to a solution of 1.5 g. 50% NaH (in oil) in 35 ml. C6H6 and the whole kept 5 hrs., refluxed 20 min., cooled, and refluxed with 12.5 g. MeI and 10 ml. C6H6 8 hrs. to give 7 g. 2-methyl-2-phenylcyclohexanone (I), b2 110°; 2,4-dinitrophenylhydrazone m. 175-6°. A mixture of 31.3 g. I, 14.3 g. malononitrile, 2.7 g. AcONH4, 1.5 ml. AcOH, and 60 ml. C6H6 is refluxed 13 hrs. to give 14 g. 2-methyl-2-phenyl-Δ1,α -cyclohexanemalononitrile (II), b0.1 150-1°. A solution of 4.5 g. II in 40 ml. MeOH is subjected to catalytic reduction using 0.2 g. PtO2 under high pressure at room temperature, and the oily product (4.6 g.) in 55 ml. BuOH refluxed with 14.8 g. KOH (150-60°) 12 hrs. to give 3 g. 2-methyl-2-phenylcyclohexaneacetic acid (III), m. 130-1° (EtOH). A mixture of 3.9 g. III and 56 g. polyphosphoric acid is heated 2 hrs. at 110° to give 3.5 g. 4α-methyl-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (IV), b2 140°. To a solution of 3 g. IV in 17 ml. dioxane are added 3.5 ml. Am nitrite and a solution of 0.36 g. Na in EtOH, the whole kept 6 hrs. at 0-5° and then 40 hrs. at 10°, Et2O added, and the pH adjusted to 5.0 to give 2.4 g. 4a-methyl-10-isonitroso-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (V), oil; 2,4-dinitrophenylhydrazone m. 226-7°. Catalytic reduction of 1.2 g. V in 30 ml. EtOH over 0.1 g. Pd-C (autoclave) gives 90% 4a-methyl-10-amino-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (VI); hydrochloride m. 173-5°; it exhibits morphine-like analgesic activity.

Yakugaku Zasshi published new progress about Analgesics. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Product Details of C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dayagi, Shlomo; Degani, Jair; Friedlander, Ruth; Patai, Saul published the artcile< Tritylation and detritylation of active methylene compounds. IV. Formation and reactions of some hexasubstituted ethanes>, Quality Control of 90940-40-2, the main research area is .

Attempts were made by various methods to prepare hexasubstituted ethanes Ph3CCXYZ, where X and Y are strongly electron-attracting groups and Z is alkyl or aryl. Use of different active methine compounds gave the desired products in only a few cases. Heterolysis of these compounds was much more difficult than when Z = H.

Journal of the Chemical Society published new progress about Methylene group. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Quality Control of 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Julia, Marc; Julia, Sylvestre; Bemont, Bernard published the artcile< Cyclopropane acids>, HPLC of Formula: 90940-40-2, the main research area is .

γ-Chloroesters, easily prepared from γ-lactones, were cyclized to cyclopropanecarboxylic esters in good yield by strong bases. Substituted derivatives had the trans configuration, presumably owing to isomerization (during the reaction) of any cis isomer present. BzCH2CH2CO2H (178 g.) in 200 ml. warm 20% NaOH was reduced with 30 g. KBH4 (added in small portions) to give 90% PhCH.CH2.CH2.C(O).O (I). The same procedure also gave the p-MeO, p-Cl (m. 50°), p-Me, and p-Br (m. 83°) derivatives of I, and BzCMe2CH2CO2H (II) and BzCH2CMe2CO2H gave the corresponding lactones, m. 56-7° (III), and 48°, resp. The chloroesters were prepared by two methods. A: a solution of 10 g. I in 58 cc. EtOH was saturated with dry HCl, kept 48 hrs., evaporated, poured onto ice, and the mixture saturated with NaCl, extracted with Et2O, and distilled to give 66% PhCHClCH2CH2CO2Et (IV), b0.1 115°, decomposed on repeated distillation B: 216 g. SOCl2 was added to 96 g. I in 144 g. C6H6, the mixture boiled 3 hrs., cooled, and slowly added to 480 cc. alc. HCl; removal of solvent and distillation gave 97% IV. The following substituted Et 4-chlorobutyrates were prepared similarly [substituents, b.p. (mm.), method, and % yield given): 4-Me, 78° (10), A, 55, B, 89; 4,4-di-Me, -, B, used without purification; 4-(p-MeOC6H4), – (not distilled), A, 96 (B failed); 4-(p-ClC6H4), 125-6° (0.05), A, 75, B, 95; 4-(p-MeC6H4), 108-10° (0.05), A, 87, B, 82; 4-(p-BrC6H4), 128-9° (0.05), A, 91, B, 90; 4,3,3-PhMe2, 145° (5), B, 60. To 15 g. IV was added 40 cc. 1.7N tert-AmONa in C6H6. The solution warmed, became red, and a precipitate formed. After 30 hrs., the mixture was boiled 5 hrs., cooled, quenched in H2O, extracted with Et2O and distilled, b0.2 101-40°. The distillate was shaken with 2.8% aqueous KMnO4 to a permanent color, the MnO2 removed and washed with H2O and Et2O, and the combined extracts distilled to give 77% trans-PhCH.CH2.CHCO2Et (V), b0.2 105-6°, m. 38-9°, hydrolyzed by KOH-MeOH to the trans-acid (VI), m. 90°, whose anilide (VII) m. 145°. IV was also cyclized by NaNH2 in liquid NH3 (67% yield), MeONa in MeOH (45% yield of VI), PhCMe2ONa in C6H6 (61% VI), tert-BuOK in tert-BuOH (64% VI), PhCMe2OK in PhCMe2OH at 100° (64% VI), and alc. NaOEt (58% VI). The cis isomer of VI (Burger, CA 42, 6755f) was esterified with CH2N2, the ester boiled 4 hrs. with tert-AmONa in C6H6 and hydrolyzed to give 73% VI. Similarly, tert-BuONa and EtONa gave 47 and 20% VI, resp. The anilide of cis-VI (VIII) m. 146-7°; a mixture of VII and VIII m. 120°. The following Et cyclopropanecarboxylates and derivatives were prepared similarly [substituents, b.p. (mm.), cyclizing agent, and % yield given]: none, 95-7° (330) (n22D 1.4242), tert-AmONa, 45 (PhCMe2ONa, 47) (acid b26 89-90%, n20D 1.4391; S-benzylthiuronium salt m. 151°); 2-Me, 65-70° (14), tert-AmONa, 50 (acid b10 92°, n21D 1.4384; anilide m. 110°); 2,2-Me2, 90° (15) (n19D 1.4280), tert-AmONa, 50 (acid b143 140°, n20D 1.4390; amide m. 172-3°); 2-(p-MeOC6H4), 124-6° (0.05) (m. 78-9°), tert-AmONa, 84 (acid m. 112-13°; anilide m. 171°); 2-(p-MeC6H4), 108° (0.6) (m. 28°), tert-AmONa, 61 (acid m. 119°; anilide m. 161°); 2-(p-BrC6H4), 130° (0.8) (m. 32°), tert-AmONa (acid m. 122°; anilide m. 175°); 2,3,3-PhMe2 (IX), 110-20° (5) (n19D 1.5040), by cyclizing the chloroester from III with NaCPh3, 10.3 (acid m. 100-1°) [also prepared (18%) from Me2C.CHPh.CH2.C(O).O (X) with SOCl2 and then tert-AmONa]. To 4.5 g. V in 120 cc. Et2O, 1 g. LiAlH4 was added in small portions with cooling, the mixture kept 4 hrs., boiled 12 hrs., and hydrolyzed (first with moist Et2O and then with H2O added dropwise); extraction, alk. hydrolysis of unchanged V, further extraction, and distillation gave 66% trans-PhCH.CH2.CHCH2OH, b3 125°, n25D 1.5412; phenylurethan m. 88-9°; 3,5-dinitrobenzoate m. 126-7°. Similarly, IX (cis-trans mixture) was reduced to the carbinol isomer mixture, b0.05 101-2°, n17D 1.5316; phenylurethan m. 122°; 3,5-dinitrobenzoate m. 114°. In an attempt to prepare II, PhCOCBrMe2 and NaCH(CO2Et)2 in boiling alc. gave (instead of II) 92% PhCOCMe:CH2, b0.5 85-90°; 2,4-dinitrophenylhydrazone m. 228°; semicarbazone m. 186-7°. The same reagents in HCONMe2 heated 3 hrs. at 100° and the product distilled and crystallized from Et2O-petr. ether gave 61% PhC:C(CO2Et).CO2.CMe2 (XI), b0.25 147-9°, m. 75-6°, λ 270 mμ (log ε 3.78), and from the mother liquors 3% PhC:C(CO2H).CO2.CMe2 (XII), m. 165° (also obtained from XI and KOH-MeOH), and a trace of II, m. 85°. XII (5 g.) in 50 cc. alc. was reduced with 0.5 g. 10% Pd-C and 16 kg./sq. cm. H, and the saturated lactone-acid decarboxylated at 120° in vacuo and distilled to give 68% X, b0.5 140°, m. 93-4°.

Bulletin de la Societe Chimique de France published new progress about UV and visible spectra. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, HPLC of Formula: 90940-40-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fuchs, Richard; Bloomfield, Jordan J. published the artcile< Transmission of electronic effects by the cyclopropane ring. Rates of alkaline hydrolysis of ethyl cis- and trans-2-phenylcyclopropanecarboxylates>, Formula: C10H9ClO2, the main research area is .

The rates of alk. hydrolysis of a series of m- and p-substituted Et β-phenylpropionates and of Et trans- and cis-2-(substituted phenyl)cyclopropanecarboxylates in 7.8% ethanol at 30° were measured. A comparison of Hammett ρ-values for these series, Et cis- and trans-cinnamates, and Et phenylpropiolates indicates that the influence of substituents on the reactivity increases in the six ester series in the order given above.

Journal of Organic Chemistry published new progress about Hydrolysis. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Formula: C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marc, Julia; Sylvestre, Julia; Bemont, Bernard published the artcile< Preparation of cyclopropane acids from γ-lactones>, COA of Formula: C10H9ClO2, the main research area is .

Cyclization of γ-chlorinated esters, readily obtained from the corresponding lactones, gave good yields of esters of cyclopropanecarboxylic acid by treatment with bases under anhydrous conditions. Thus, with tert-AmONa or PhCMe2ONa in C6H6, Cl(CH2)3CO2Et was cyclized to Et cyclopropanecarboxylate; the free acid was characterized as its S-benzylthiuronium salt, m. 161°. Similarly, the anilide of 2-methylcyclopropanecarboxylic acid, m. 109°, resulted from the Et ester of the latter, produced from MeCHCl(CH2)2CO2Et. From BzCH2CH2CO2H was obtained γ-phenyl-γ-butyrolactone, converted by SOCl2 in C6H6 to PhCHClCH2CH2CO2Et, which, boiled with Me3-COK several hrs. and the solution washed with KMnO4 to remove olefinic compounds and distilled yielded Et 2-phenylcyclopropanecarboxylate, b0.2 105-6°, m. 38° (petr. ether); hydrolysis of the ester produced the free trans acid, m. 90° (anilide, m. 145°). Analogous procedures yielded 2-(p-chlorophenyl)cyclopropanecarboxylic acid, m. 112°; p-BrC6H4 analog, m. 122°; p-MeOC6H4 analog, m. 112° (Et ester, m. 79°). The latter compounds were prepared by condensation of succinic anhydride with the aromatic derivatives, reduction to the lactones, and conversion of the latter to the cyclopropanecarboxylic acids.

Compt. rend. published new progress about Lactones. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, COA of Formula: C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics