Category: 93118-03-7

Zhu, Junjie published the artcileDesign, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists in the treatment of type 2 diabetes mellitus and other metabolic disorders, COA of Formula: C8H4ClF3O, the main research area is dihydro oxadiazole preparation TGR5 agonist treatment diabetes metabolic disorder.

Given its role in the mediation of energy and glucose homeostasis, the G-protein-coupled bile acid receptor 1 (TGR5) is considered a potential target for the treatment of type 2 diabetes mellitus and other metabolic disorders. By thorough anal. of diverse structures of published TGR5 agonists, a hypothetical ligand-based pharmacophore model was built, and a new class of potent TGR5 agonists, based on the novel 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazole core, was discovered by rational design. Three distinct synthetic methods for constructing 4,5-dihydro-1,2,4-oxadiazoles, e.g., I, and extensive structure-activity relationship studies are reported herein. Compound I, the structure of which was determined by single-crystal X-ray diffraction and quantum chem. solid-state TDDFT-ECD calculations, showed the best potency, with an EC50 value of 1.4 nM toward hTGR5. Its favorable properties in vitro warrant further investigation.

ChemMedChem published new progress about Antidiabetic agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kethireddy, Shashikala published the artcileSynthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is Escherichia Staphylococcus Pseudomonas Streptococcus antibacterial tetrahydroimidazo pyrimidine carbohydrazide derivative; 2-Amino pyrimidine; Antibacterial activity; Imidazo[1,2-a]pyrimidine-hydrazones; Norfloxacin.

Background: The intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biol. activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, antipyretic and anti-inflammatory properties. Results: Condensation of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide 7 with aromatic aldehydes a-k in ethanol at reflux led to the generation of hydrazone derivatives 8a-k in 80-92% yield. The synthesis of carbohydrazide 7 was accomplished in six steps from com. available 2-amino pyrimidine. The structures of the synthesized compounds were confirmed by 1H, 13C NMR, Mass and IR spectral data. All the synthesized hydrazone derivatives 8a-k were tested in vitro for their antibacterial activity. Compounds 8d, 8e and 8f exhibited excellent antibacterial activity with zone of inhibition 30-33 mm against E. coli (Gram neg. bacteria) and S. aureus (Gram pos. bacteria). These compounds also exhibited excellent antibacterial activity with zone of inhibition 22-25 mm against P. aeruginosa (Gram neg. bacteria) and S. pyogenes (Gram pos. bacteria). Conclusion: Synthesized and recorded antibacterial activity of some new 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine-hydrazone derivatives

Chemistry Central Journal published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruso, Jayaraman Sembian published the artcileAntimicrobial activities of novel 3-substituted-[1,2,4]triazolo[4,3-b]pyridazine derivatives, Application In Synthesis of 93118-03-7, the main research area is triazolopyridazine preparation antibacterial antifungal.

A novel derivatives of 3-substituted-[1,2,4]triazolo[4,3-b]pyridazine I [R = 3-C6H4Br, 2,6-C6H3Cl2, 4-C6H4COOH, etc.] and 7,8,9,10-tetrahydrobenzo[4,5]thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine II [R1 = 3-C6H4Br, 2-C6H4CF, cyclopropyl, etc.] were prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of Me4NBr and oxone. The derivatives I and II were subjected to preliminary antimicrobial activities against microorganism. All these compounds I and II exhibit good to moderate activity.

Journal of the Korean Chemical Society published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruso, Jayaraman Sembian published the artcileAntimicrobial activities of novel 3-substituted[1,2,4]triazolo[4,3-b]pyridazine derivatives, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is triazolopyridazine preparation antibacterial antifungal.

A novel derivatives of 3-substituted[1,2,4]triazolo[4,3-b]pyridazine I (R1 = 3-BrC6H4, 2-Br-6-ClC6H3, 2,6-Cl2C6H3, etc.) and 7,8,9,10-tetrahydrobenzo[4,5]thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine II (R2 = 3-BrC6H4, 4-Br-C6H4, 2-F3CC6H4, etc.) were prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of Me4NBr and oxone. These derivatives were subjected to preliminary antimicrobial activities against microorganism. All the compounds exhibited good to moderate activity.

Hwahak Sekye published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajasekhar, M. published the artcileSynthesis and antimicrobial activity of novel chalcone analogues bearing 2-furan trifluoromethyl ring, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is chalcone preparation antibacterial activity; apocynin ethyl trifluoro acetoacetate benzaldehyde fluorinated Claisen Schmidt reaction.

Preparation of chalcone I (R = 4-Cl, 2-CF3, 3-CF3, etc.) derivatives from Et 4,4,4-trifluoroacetoacetate and apocynin and their antibacterial activity. All the compounds I were screened in-vitro (at a concentration: 10 μg/disk) for their antibacterial activity against two gram-pos. strains (Staphylococcus aureus and Bacillus subtilis) and two gram-neg. strains (Escherichia coli and Pseudomonas aeruginosa). Results of the antibacterial data revealed that among all the compounds tested, compound I (R = 2-CF3, 3-CF3, 4-CF3, 4-OCF3, 4-OCHF3) showed excellent activity, while compounds I (R = 4-F, 2,4-F2, 3,4-F2, 2,6-F2) displayed good activity against all the tested bacteria.

Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hu, Baihua published the artcileDiscovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRβ, Safety of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is cinnoline quinoline derivative preparation structure liver X receptor agonist.

A series of cinnolines/quinolines was prepared and it was found that 4-phenyl-cinnoline/quinolines with either a 2′,3′ or 2′,5′-disubstituted benzyloxy moiety or the 1-Me-7-indole methoxy moiety on the meta position of the 4-Ph ring showed good binding selectivity for LXRβ over LXRα. The LXRβ binding selective modulators displayed good activity for inducing ABCA1 gene expression in J774 macrophage cell line and poor efficacy in the LXRα Gal4 functional assay. 26, 37 and 41 were examined for their ability to induce SREBP-1c gene expression in Huh-7 liver cell line and they were weak partial agonists.

Bioorganic & Medicinal Chemistry published new progress about Antiatherosclerotics. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Safety of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kulathooran, S. published the artcileSynthesis and biological evaluation of some new chalcones using anhydrous potassium carbonate as an efficient basic catalyst by conventional and microwave assisted techniques, Quality Control of 93118-03-7, the main research area is chalcone furanyl preparation green chem antibacterial antifungal activity SAR; aryl aldehyde furan Claisen Schmidt reaction microwave irradiation diastereoselective.

Series of novel 3-(substituted aryl)-1-(5-methylfuran-2-yl)prop-2-en-1-one derivatives I [R = 3-furanyl, 2-F-3-MeOC6H3, 3-Cl-2-FC6H3, etc.] were synthesized from com. available 2-acetyl-5-methylfuran and various substituted aromatic aldehydes in presence of anhydrous potassium carbonate in ethanol solution and by microwave irradiation method with good yield compared to conventional method. Anhydrous potassium carbonate was utilized as safe, inexpensive and efficient basic catalyst for synthesis of chalcones. The structures of the all synthesized compounds were established on the basis of IR, Mass, 1H NMR and 13C NMR. The antimicrobial activities of these derivatives were evaluated by quantifying the minimal inhibitory concentration (MIC) against various microbial strains such as Escherichia coli [ATCC-9637], Staphylococcus aureus [ATCC-25923], Klebsiella pneumonia [ATCC-13883], Candida albicans [ATCC-28366], Rhizopus arrhizus [ATCC-11145] and Aspegillus niger [ATCC-26036]. Among the tested compounds, compound I [R = 5-Me-3-indolyl] exhibited strong microbial activity against most of the microbial strains except A. niger.

International Journal of Pharmaceutical Sciences and Research published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kulathooran, S. published the artcileSynthesis and biological activities of novel heterocyclic chalcone derivatives by two different methods using anhydrous potassium carbonate as an efficient catalyst, Application In Synthesis of 93118-03-7, the main research area is acetyl dimethylfuran aryl aldehyde potassium carbonate catalyst microwave irradiation; chalcone preparation diastereoselective green chem antibacterial antifungal activity SAR.

A series of twenty 3-(aryl)-1-(2,5-dimethylfuran-3-yl)prop-2-en-1-one I [R = 2,5-(F)2-C6H3, 2-naphthyl, 2-biphenyl, etc.] were synthesized by using conventional and microwave irradiation methods in the presence of anhydrous potassium carbonate as an safe, inexpensive and efficient basic catalyst. Synthesized compounds were evaluated for their in-vitro antimicrobial activity against variety of microbial strains and it was characterized by IR, NMR (1H & 13C) and mass spectral anal. The biol. screening results indicated that some of the compounds showed significant antibacterial and antifungal activities. Compound I [R = 3-methyl-2-thiophenyl] displayed excellent antimicrobial activity against various microbial strains. The newly synthesized high potent compound I [R = 3-methyl-2-thiophenyl] was subjected to thermogravimetric anal. (TGA), differential scanning calorimetric (DSC) and single crystal XRD.

Pharma Chemica published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruso, Jayaraman Sembian published the artcileOxidative cyclisation based one-pot synthesis of 3-substituted[1,2,4]triazolo[4,3-b]pyridazines using Me4NBr/oxone, Synthetic Route of 93118-03-7, the main research area is triazolopyridazine derivative preparation oxidative cyclization.

A facile one-pot synthesis of 3-substituted triazolopyridazine and thieno-triazolopyridazine derivatives is described. This protocol involves the preparation of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative followed by subjecting the intermediate directly to oxidative cyclization to assemble the desired 1,2,4-triazole moiety by employing the mixture of Me4NBr and oxone. This condition is efficient and is able to tolerate wide range of functional groups.

Journal of the Korean Chemical Society published new progress about Oxidative cyclization. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Synthetic Route of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saha, Debasmita published the artcileRapid Access to New Thiazepinyl and Oxazepinyl Phosphonates through a Green Pudovik Reaction, COA of Formula: C8H4ClF3O, the main research area is thiazepinyl oxazepinyl phosphonate preparation green Pudovik reaction; dibenzothiaoxazepin dibenzoxazepine imine cyclic alpha amino phosphonate preparation; crystal mol structure dibenzothiazepinyl phosphonate.

A simple, facile, and efficient microwave-assisted synthetic protocol for the preparation of novel dibenzothiazepinyl and dibenzoxazepinyl phosphonates has been reported. The present Pudovik approach works without a catalyst or solvent to furnish cyclic α-amino phosphonates by using dibenzothia- and dibenzoxazepines as imine substrates. This method has a greener edge and is amenable to large-scale production

Asian Journal of Organic Chemistry published new progress about Addition reaction (Pudovik). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics