Category: 93118-03-7

Dascalu, Anca-Elena published the artcileDesign, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is hydrazine hydrazone pyrrolidinone preparation antifungal toxicity SAR; Antifungal agents; Biological screening; Hydrazine; Hydrazone; Pyrrolidin-2-one.

Twenty-eight 5-pyrrolidine-2-ones decorated by hydrazine or acyl hydrazones groups have been designed, synthesized and evaluated as antifungal agents on a panel of twelve fungal strains and three non albicans candida yeasts species which have demonstrated reduced susceptibility to commonly used antifungal drugs. Half of the target compounds exhibited good to high antifungal activities on at least one strain with MIC50 lower than the control antifungal agent – hymexazol or ketoconazole. 5-Arylhydrazino-pyrrolidin-2-ones were found active and the -NH-NH- linker proved to be essential to maintain the antifungal potential. Compound I is a broad-spectrum antifungal, active on 60% of the tested strains. Replacing the hydrazine linker by an acylhydrazone one narrowed the spectrum of activity but pyroglutamylaryl hydrazones, mainly aromatic ones, exhibited good activity, adequate “”fungicide-like”” properties and were devoted of cytotoxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about Diastereoselective synthesis. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khera, Rasheed Ahmad published the artcileSynthesis of fluorinated 2,3-dihydropyran-4-ones by cyclocondensation of 1,3-dicarbonyl dianions with aldehydes, Category: chlorides-buliding-blocks, the main research area is pyranone dihydrotrifluoromethyl preparation; pentanedione fluorinated aldehyde cyclocondensation.

The reaction of the dianion of 1,1,1-trifluoro-pentane-2,4-dione with aldehydes and subsequent addition of hydrochloric acid afforded 2,3-dihydro-6-trifluoromethyl-pyran-4-ones. The reaction of the dianion of acetylacetone with fluorinated benzaldehydes gave the corresponding fluorinated 2-aryl-2,3-dihydro-6-methyl-pyran-4-ones. All reactions proceeded in very good yield and with very good regioselectivity. While 2 crystal structures were determined, no data are reported here.

Journal of Fluorine Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Huan published the artcileCationic palladium(II)-catalyzed synthesis of 2-substituted 3-hydroxymethylbenzo[b]furans, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is hydroxymethylbenzofuran preparation; benzofuran hydroxymethyl preparation; alkynyl phenol preparation heterocyclization aldehyde palladium catalyst.

A tandem reaction involving an intramol. oxypalladation of an alkyne and an addition to the carbonyl group to quench the carbon-palladium bond to complete the catalytic cycle was developed. The reaction of 2-alkynylphenols with aldehydes to prepare substituted 3-(hydroxymethyl)benzofurans in one pot is described. E.g, reaction of 2-(phenylethynyl)phenol and p-nitrobenzaldehyde, catalyzed by [Pd(dppp)(H2O)2](BF4)2, gave 90% benzofuran (I). The reaction was catalyzed with the cationic palladium(II) species without the necessity of a redox system.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Warsitz, Michael published the artcileTwo-Step Procedure for the Synthesis of 1,2,3,4-Tetrahydro-quinolines, Related Products of chlorides-buliding-blocks, the main research area is chlorostyrene aniline alkyl titanium regioselective hydroaminoalkylation catalyst; amine aryl alkyl preparation palladium Buchwald Hartwig amination; tetrahydroquinoline preparation.

A new two-step procedure that includes an initial regioselective intermol. hydroaminoalkylation of ortho-chlorostyrenes with N-methylanilines and a subsequent intramol. Buchwald-Hartwig amination gives direct access to 1,2,3,4-tetrahydroquinolines. The hydroaminoalkylation reaction of the ortho-chlorostyrenes is catalyzed by a 2,6-bis(phenylamino)pyridinato titanium complex which delivers the linear regioisomers with high selectivities. In addition, the formation of unexpected dihydroaminoalkylation products from styrenes and N-methylanilines is reported.

European Journal of Organic Chemistry published new progress about Aminoalkylation (regioselective hydroaminoalkylation). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jung, Michael E. published the artcileStructure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry, COA of Formula: C8H4ClF3O, the main research area is phenyl azide photoaffinity inhibitor anthrax toxin semicarbazone EGA SAR; Photoaffinity labeling; anthrax lethal toxin; aryl azide; endosomal trafficking; semicarbazone.

[In this abstract compounds 1-5 are represented by graphic structure I as follows: 1: X, Y = H, Z = Br; 2: X = F, Y = H, Z = Br; 3: X = F, Y = H, Z = N3; 4: X, Y = H, Z = N3; 5: X, Y = F, Z = N3]. EGA, 1, prevents the entry of multiple viruses and bacterial toxins into mammalian cells by inhibiting vesicular trafficking. The cellular target of 1 is unknown, and a structure-activity relationship study was conducted in order to develop a strategy for target identification. A compound with mid-nanomolar potency was identified (2), and three photoaffinity labels were synthesized (3-5). For this series, the expected photochem. of the Ph azide moiety is a more important factor than the IC50 of the photoprobe in obtaining a successful photolabeling event. While 3 was the most effective reversible inhibitor of the series, it provided no protection to cells against anthrax lethal toxin (LT) following UV irradiation Conversely, 5, which possessed weak bioactivity in the standard assay, conferred robust irreversible protection vs LT to cells upon UV photolysis.

ACS Medicinal Chemistry Letters published new progress about Alkylation, regioselective (of semicarbazone core). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bladen, Chris published the artcileSynthesis and Evaluation of 1,4-Dihydropyridine Derivatives with Calcium Channel Blocking Activity, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is quinolinone hexahydro carboxylate aryl preparation calcium channel blocker; pyridine dihydro cyclohexanone fused carboxylate preparation calcium channel blocker.

1,4-Dihydropyridines (DHPs) are an important class of L-type calcium channel blockers that are used to treat conditions such as hypertension and angina. Their primary target in the cardiovascular system is the Cav1.2 L-type calcium channel isoform, however, a number of DHPs also block low-voltage-activated T-type calcium channels. Here, the synthesis of a series of novel fused dihydropyridines I (R1 = H, Me; R2 = Me, Et, i-Bu, t-Bu, PhCH2, 3-pyridylmethyl; R3 = 2,3-F2, 2-Cl-3-F3C, 2-HO-5-O2N, 2-PhCO2-5-O2N) and their abilities to block both L- and T-type calcium channels are described. Within this series of compounds, modification of a key ester moiety not only regulates the blocking affinity for both L- and T-type channels, but also allows for the development of DHPs with 30-fold selectivity for T-type channels over the L-type. The data suggest that a condensed dihydropyridine-based scaffold may serve as a pharmacophore for a new class of T-type selective inhibitors.

Pfluegers Archiv published new progress about Hantzsch cyclocondensation reaction. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saha, Debasmita published the artcileA sequential synthetic strategy towards unexplored dibenzo[b,f][1,4]thiazepine carboxamides: copper catalyzed C-S cyclization followed by Ugi type 3CC cascade, Category: chlorides-buliding-blocks, the main research area is carboxamide dibenzothiazepine preparation; dibenzothiazepine preparation isocyanide carboxylic acid Ugi reaction; aminothiophenol halo benzaldehyde copper catalyst cyclization.

A two-step diversity oriented synthetic protocol to a novel class of dihydrodibenzo[b,f][1,4]thiazepine-11-carboxamides was developed. The first step ensured the synthesis of dibenzothiazepine via copper-mediated condition followed by Ugi-Joullie reaction of the resultant cyclic imine in the second step.

RSC Advances published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Parle, Amrita published the artcileSynthesis, characterization and evaluation of 3-acetylindole derivatives as potential antifungal agents, Application In Synthesis of 93118-03-7, the main research area is acetylindole preparation antifungal activity.

In the present study, a series of novel 3-acetylindole derivatives I (R = 3,5-dibromophenyl, 2-chloro-5-nitrophenyl, 2-(trifluoromethoxy)phenyl, etc.) was synthesized by reacting 3-acetylindole and benzaldehydes RCHO. The synthesized 3-acetylindole derivatives I were characterized physicochem., by elemental anal. and spectral (IR and 1H-NMR) anal. The synthesized compounds I were screened for their in-vitro antifungal activity against Candida albicans, Rhizopus oligosporus, Gibberella fuzikuroi and Asperigillus niger by cup plate method. The results revealed that five compounds namely I (R = 5-hydroxy-2-nitrophenyl, 2-chloro-3-(trifluoromethyl)phenyl, 4-nitrophenyl, 4-methoxy-3-nitrophenyl and 5-chloro-2-nitrophenyl) have better or equal antifungal activity compared to the standard fluconazole.

Pharma Innovation published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Szlachcic, Pawel published the artcileFacile and Regioselective Synthesis of Substituted 1H-Pyrazolo[3,4-b]quinolines from 2-Fluorobenzaldehydes and 1H-Pyrazol-5-amines, Synthetic Route of 93118-03-7, the main research area is pyrazoloquinoline preparation; fluorobenzaldehyde pyrazolamine regioselective condensation.

The present article concerns the scope and limitations of the regioselective condensation of 2-fluorobenzaldehydes with 1H-pyrazol-5-amines, leading to the synthesis of substituted 1H-pyrazolo[3,4-b]quinolines (PQ), in the presence of a base catalyst (DABCO and 2,4,6-trimethylpyridine). A method to obtain these nitrogen heterocycles with fluorine or trifluoromethyl substituents in different positions in the carbocyclic ring was developed as a part of a systematic research on the influence of fluorine-containing substituents on the parameters of PQ. Those compounds, characterized by high-fluorescence intensity, have been tested as emitters for the organic light-emitting diodes since 1997. The functionalization of PQ causes changes in various parameters, for example, HOMO and LUMO levels, which are important for the adjustment of fabricated organic light-emitting diodes. One of the easiest methods of PQ preparation, namely, the condensation of substituted anilines with 5-chloro-1H-pyrazole-4-carbaldehydes, is not regioselective. The method described in this study allows synthesizing of 1H-pyrazolo[3,4-b]quinolines with good yields and high selectivity-only the expected isomer is obtained. As various different 2-fluorobenzaldehydes are com. available, and 1H-pyrazol-5-amines with different substituents are easy to prepare, the method could be a good alternative to the already known procedures. All possible mechanisms of the reaction were also thoroughly studied.

Journal of Heterocyclic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Synthetic Route of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Surasani, Rajendra published the artcileFeF3 as a novel catalyst for the synthesis of polyhydroquinoline derivatives via unsymmetrical Hantzsch reaction, Synthetic Route of 93118-03-7, the main research area is hydroquinoline poly preparation Hantzsch condensation iron fluoride catalyst; aldehyde diketone dimedone 4 component condensation iron fluoride catalyst; ferric fluoride catalyst polyhydroquinoline preparation 1 pot Hantzsch condensation.

A facile and highly efficient one-pot synthesis of polyhydroquinoline derivatives is reported via four-component condensation reaction of aldehydes, β-keto compounds, active methylene compounds and ammonium acetate in the presence of FeF3 as a catalyst in ethanol at 75-80 °C. The method offers several advantages including high yields, short reaction time, simple work-up procedure and catalyst reusability for several runs. The higher catalytic activity of FeF3 ascribed due to its high acidity, thermal stability and water tolerance. The superiority of use of FeF3 to the current process is compared with other Lewis acids, Fe-salts, fluoride sources and insights of the origin of the efficiency are discussed.

Journal of Fluorine Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Synthetic Route of 93118-03-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics